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ClinicalTrials.gov public records Last synced Nov 9, 2026, 10:50 AM EST

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Showing 25–45 of 45 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Low-Processed Food Diet Clear all

Conditions: Nutrition, Health, Dietary Habits
Interventions: Diet A, Diet B, Diet C; Other
Lead sponsor: RTI International; Other
Eligibility: 18 Years and older
Enrollment: 8,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 14
States / cities: Birmingham, Alabama • Davis, California • Los Angeles, California + 7 more

Conditions: Metabolic Syndrome
Interventions: Higher protein, low glycemic load diet; Dietary Supplement
Lead sponsor: University of Arkansas, Fayetteville; Other
Eligibility: 18 Years to 85 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Fayetteville, Arkansas

Conditions: Depression
Interventions: Low UPF Meals (Study Provided), Low UPF Nutritional Guidance, Low UPF Snacks (Study Provided); Other
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Will Consuming Eggs With a Mixed Vegetable Salad Increase Carotenoid Absorption
Interventions: Egg consumption; Other
Lead sponsor: Purdue University; Other
Eligibility: 19 Years to 45 Years · Male only
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: West Lafayette, Indiana

Conditions: Breast Cancer
Interventions: Diabetes Prevention Program-based lifestyle change intervention (DPP), Highly Microbiota-Accessible Foods (HMAFs) intervention; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 50 Years to 75 Years · Female only
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Non-Alcoholic Fatty Liver Disease, Obesity
Interventions: Moderately carbohydrate-restricted diet, Fat-restricted diet; Other
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 10 Years to 17 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Asthma
Interventions: Prudent diet, Western diet; Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Type 2 Diabetes Mellitus
Interventions: Low Glycemic Diet, Control Diet; Other
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 35 Years to 65 Years
Enrollment: 65 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Alzheimer Disease
Interventions: Mediterranean Diet, Study Supplement, Low-fat Diet; Behavioral · Dietary Supplement
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 65 Years and older
Enrollment: 209 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Obesity
Interventions: GF-IGB: Obalon Balloon, Medically Supervised Meal Replacement Program: My New Weigh, Endoscopic sleeve gastroplasty: (ESG); Device · Dietary Supplement · Procedure
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 22 Years to 65 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Overweight , Obesity, Class I Obesity
Interventions: Low-processed DGA Diet, Ultra-processed DGA Diet; Other
Lead sponsor: USDA Grand Forks Human Nutrition Research Center; Federal
Eligibility: 18 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Grand Forks, North Dakota

Conditions: Diet Therapy
Interventions: Western Diet, CLEAN-MED; Other
Lead sponsor: National Institutes of Health Clinical Center (CC); NIH
Eligibility: 18 Years to 60 Years
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
Interventions: Glycemic load, Calorie restriction, Behavioral support; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 2
States / cities: Birmingham, Alabama • St Louis, Missouri

Conditions: Overweight and Obesity
Interventions: Exercise Protocol, Calorie-Restrictive Low Carbohydrate Diet (CR-LC), Ancestral Diet (AD); Other
Lead sponsor: University of Miami; Other
Eligibility: 18 Years to 65 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Depression, Major Depressive Disorder, Weight Gain, Obesity, Metabolic Syndrome
Interventions: Reduction of Ultra-processed foods; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Food Addiction
Interventions: Low UP (meals provided), Low UP (self-guided), Active Control; Other
Lead sponsor: University of Michigan; Other
Eligibility: 22 Years to 60 Years
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Healthy Nutrition
Interventions: Low-Processed Food Diet; Other
Lead sponsor: Oklahoma State University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Stillwater, Oklahoma

Conditions: Ultra-Processed Food Intake, Obesity & Overweight
Interventions: Introductory Educational Workshop, Standard Dietary Change (ON/OFF), Cognitive Dissonance Strategies (ON/OFF); Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 18 Years to 70 Years
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Springfield, Oregon

Conditions: Healthy
Interventions: Emulsifier-containing diet; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 60 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Food Addiction, Withdrawal
Interventions: Dietary Change (low in highly processed foods); Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 25 Years to 40 Years
Enrollment: 68 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Endometriosis
Interventions: Plant-based Intervention Group; Behavioral
Lead sponsor: Physicians Committee for Responsible Medicine; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2029
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

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Nutrition for Precision Health, Powered by the All of Us

Diet and Health in Adults With Metabolic Syndrome

You Are What You Eat: Food as a Risk Factor and a Treatment for Depression

Effects of Egg Consumption on Carotenoid Absorption From Co-consumed, Non-Egg Food

UCLA Breast Cancer Survivor Health Promotion Research Study

Moderately Carbohydrate-restricted Diet to Treat NAFLD in Adolescents

BREATHE-Easy Trial

Return of First-phase Insulin Secretion in Type 2 Diabetes is Associated With Depletion of Pancreas Lipid

Nutrition Interventions for Cognitive Enhancement

How Gas-Filled Intragastric Balloons or Endoscopic Sleeve Gastroplasty Affect Hunger, Hunger Hormones, and Gastric Emptying Compared to Meal Replacements

Dietary Guidelines for Americans-Ultra Processed Study

Mediterranean-like Unprocessed (CLEAN-MED) Diet Intervention Study of the Gut Microbiome of Healthy Adults

Functional Outcomes From Diets in Multiple Sclerosis

Exercise and Nutrition on Obese Microbiome

Diet and Depression

Ultra Crave: An Investigation of Ultra-Processed Food

Determinants and Outcomes of High vs. Low Ultra-processed Feeding

Dietary Interventions to Reduce Ultra-Processed Food Intake

Functional Research of Emulsifiers in Humans

The Biobehavioral Impact of Diet Quality on Affect and Craving

Nutritional Intervention for Endometriosis