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Showing 1–24 of 129 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Low-level cortical stimulation Clear all
Withdrawn Phase 1 Interventional

Title: Safety and Feasibility of Individualized Low Amplitude Seizure Therapy (iLAST)

NCT03895658
View directory record Official record
Conditions
Unipolar Depression
Interventions
MRI, MagPro TMS stimulator and coil, Thymatron (R) System IV paired with 4X1 HDECT
Device
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
22 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Sep 7, 2026, 7:30 AM EDT
Completed Not applicable Interventional Results available

Acupuncture for Low-Dose Opioid for TKA Replacement

NCT04084288
View directory record Official record
Conditions
Knee Osteoarthritis, Pain, Postoperative, Acupuncture
Interventions
Acupuncture, Peripheral Nerve Stimulator
Other · Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 70 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 26, 2024 · Synced Sep 7, 2026, 7:30 AM EDT
Not listed Early Phase 1 Interventional

Repetitive Transcranial Magnetic Stimulation in Women With Overactive Bladder With Urgency Incontinence

NCT05099419
View directory record Official record
Conditions
Overactive Bladder, Urge Incontinence
Interventions
Repetitive Transcranial Magnetic Stimulation
Device
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 16, 2021 · Synced Sep 7, 2026, 7:30 AM EDT
Recruiting Not applicable Interventional

tDCS + CCFES-mediated Functional Task Practice for Post-stroke Upper Extremity Hemiplegia

NCT05866003
View directory record Official record
Conditions
Stroke, Upper Extremity Paresis, Hemiplegia
Interventions
Active conventional tDCS montage plus CCFES, Active unconventional tDCS montage plus CCFES, Sham tDCS plus CCFES, CCFES with Occupational Therapy
Device · Behavioral
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
21 Years to 90 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 28, 2025 · Synced Sep 7, 2026, 7:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Modulating Brain Activity to Improve Goal-directed Physical Activity in Older Adults

NCT04278560
View directory record Official record
Conditions
Aging
Interventions
Transcranial direct current stimulation (tDCS), Sham stimulation, Behavioral intervention to increase physical activity
Device · Behavioral
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
65 Years and older
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Roslindale, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Sep 7, 2026, 7:30 AM EDT
Completed No phase listed Observational Results available

Direct Measurement of Motor Cortical Responses to tDCS

NCT04759898
View directory record Official record
Conditions
Parkinson Disease
Interventions
transcranial direct current stimulation (invasive recording)
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 7, 2026, 7:30 AM EDT
Completed Not applicable Interventional Results available

Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Aphasia

NCT02226796
View directory record Official record
Conditions
Aphasia
Interventions
Transcranial direct current stimulation
Device
Lead sponsor
University of Minnesota
Other
Eligibility
20 Years to 85 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 17, 2022 · Synced Sep 7, 2026, 7:30 AM EDT
Recruiting Not applicable Interventional

Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study

NCT07217223
View directory record Official record
Conditions
Treatment Resistant Depression (TRD), Major Depressive Disorder (MDD)
Interventions
Spaced Transcranial Direct Current Stimulation (tDCS)
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Sep 7, 2026, 7:30 AM EDT
Completed Not applicable Interventional Results available

Combined Effect of Transcranial Direct Current Stimulation (tDCS) and Physical Activity on Gait and Functional Mobility in Participants With Multiple Sclerosis

NCT03658668
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
active tDCS, sham tDCS, Physical Activity (PA)
Device · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 70 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 15, 2023 · Synced Sep 7, 2026, 7:30 AM EDT
Completed Not applicable Interventional

Remotely-supervised Transcranial Direct Current Stimulation (tDCS) for At-home Treatment of Fatigue and Cognitive Slowing in Parkinson's Disease

NCT03189472
View directory record Official record
Conditions
Parkinson Disease
Interventions
Active tDCS, Sham tDCS
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
35 Years to 89 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2020 · Synced Sep 7, 2026, 7:30 AM EDT
Completed Not applicable Interventional Results available

Transcranial Magnetic Stimulation Treatment of Hoarding Disorder

NCT02236767
View directory record Official record
Conditions
Hoarding
Interventions
Neurostar Transcranial Magnetic Stimulation Therapy System
Device
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 5, 2016 · Synced Sep 7, 2026, 7:30 AM EDT
Recruiting Not applicable Interventional

DBS of the SCC for the Treatment of Medically Refractory CLBP

NCT04085406
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Deep Brain Stimulation of the Subgenus Cingulate Cortex
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
40 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
2
States / cities
Los Angeles, California • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Sep 7, 2026, 7:30 AM EDT
Active, not recruiting Not applicable Interventional

Neuromodulation and Cognitive Training in Opioid Use Disorder

NCT03773523
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Dependence, Opioid Abuse
Interventions
Transcranial Direct Current Stimulation (tDCS)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 7, 2026, 7:30 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Transcranial Ultrasonic Neuromodulation of Primary Visual Cortex and Primary Auditory Cortex in Humans

NCT07508722
View directory record Official record
Conditions
Healthy Volunteers, no Condition, Basic Science
Interventions
Transcranial Focused Ultrasound Stimulation, Electroencephalography, Magnetic Resonance Imaging
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
21 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 7, 2026, 7:30 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions

NCT06950060
View directory record Official record
Conditions
Stroke, Chronic, Aging, Cognitive Decline, Motor Dysfunction, Neuroplasticity
Interventions
High intensity cycling, Low-intensity cycling, Health education session, Moderate Intensity Aerobic Exercise
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 85 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 7, 2026, 7:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exploring the Relationship Between Brain Asymmetry and Attention

NCT03789201
View directory record Official record
Conditions
Normal Physiology
Interventions
TMS EEG, TMS fMRI
Device
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 35 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 25, 2022 · Synced Sep 7, 2026, 7:30 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Customized Cortical Stimulation Therapy in the Rehabilitation of Stroke Patients

NCT02544503
View directory record Official record
Conditions
Stroke
Interventions
Single-pulse Transcranial Magnetic Stimulation (TMS), Paired-pulse Transcranial Magnetic Stimulation (ppTMS), Low-frequency Repetitive Transcranial Magnetic Stimulation (rTMS), Sham Motor Cortex Stimulation
Device
Lead sponsor
Emory University
Other
Eligibility
40 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
3
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 30, 2023 · Synced Sep 7, 2026, 7:30 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Modulating Cortical Dynamics of Dual-task Standing in MCI

NCT05680701
View directory record Official record
Conditions
Aging, Mild Cognitive Impairment
Interventions
real tACS, sham tACS
Other
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
65 Years to 95 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 14, 2023 · Synced Sep 7, 2026, 7:30 AM EDT
Not listed Not applicable Interventional

Transcranial Direct Current Stimulation and Chronic Pain

NCT05863494
View directory record Official record
Conditions
Chronic Pain
Interventions
Transcranial Direct Current Stimulation (tDCS), Transcranial Direct Current Stimulation (tDCS) sham
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 79 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated May 17, 2023 · Synced Sep 7, 2026, 7:30 AM EDT
Completed Not applicable Interventional Results available

rTMS Bimodal Treatment For Tinnitus: A Pilot Study

NCT01590264
View directory record Official record
Conditions
Tinnitus
Interventions
Bimodal rTMS
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 60 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 1, 2013 · Synced Sep 7, 2026, 7:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Using PET-CT to Target and Validate Low-frequency TMS as Treatment for Tinnitus

NCT00329524
View directory record Official record
Conditions
Tinnitus
Interventions
Repetitive Transcranial Magnetic Stimulation (rTMS)
Device
Lead sponsor
University of Arkansas
Other
Eligibility
19 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated May 3, 2015 · Synced Sep 7, 2026, 7:30 AM EDT
Enrolling by invitation Not applicable Interventional

Amplitude Modulation Frequency Comparison in Kilohertz Transcranial Magnetic Perturbation (kTMP) for Chronic Stroke

NCT07681102
View directory record Official record
Conditions
Stroke
Interventions
kTMP
Device
Lead sponsor
Magnetic Tides
Industry
Eligibility
18 Years to 80 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 7, 2026, 7:30 AM EDT
Active, not recruiting Not applicable Interventional

Individualized Brain Stimulation to Improve Mobility in Alzheimer's Disease

NCT04289402
View directory record Official record
Conditions
Alzheimer Dementia, Presenile Alzheimer Dementia, Aging
Interventions
Personalized tDCS, Active-Sham
Other
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
65 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Roslindale, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 7, 2026, 7:30 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Restoration of Consciousness With Ultrasonic Deep Brain Stimulation During Anesthetic Sedation

NCT07221539
View directory record Official record
Conditions
Mental Function
Interventions
Propofol for fMRI, Dexmedetomidine for fMRI, Dorsolateral prefrontal cortex (DLPFC) pulsation, Anterior insular cortex (AIC) pulsation, Central thalamus (CT) pulsation
Procedure · Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 40 Years
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Sep 7, 2026, 7:30 AM EDT