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Showing 1–24 of 155 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Lumbar spine surgery Clear all
Not listed Not applicable Interventional

Study of Nucel for One and Two Level Lumbar Interbody Fusion

NCT02808234
View directory record Official record
Conditions
Degenerative Disc Disease, Spondylolisthesis, Spondylosis
Interventions
One or two level lumbar interbody fusion surgery, Nucel
Procedure · Other
Lead sponsor
Organogenesis
Industry
Eligibility
18 Years to 75 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
3
States / cities
Tampa, Florida • Shreveport, Louisiana • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Sep 21, 2026, 1:06 AM EDT
Terminated Phase 2 Interventional

Safety and Efficacy of Pre-incisional Intravenous Ibuprofen to Reduce Postoperative Pain and Opioid Dependence After Posterior Cervical or Lumbar Instrumented Spine Surgery

NCT02276911
View directory record Official record
Conditions
Cervical Spondylosis, Lumbar Spondylosis
Interventions
Ibuprofen, normal saline
Drug · Other
Lead sponsor
St. Joseph's Hospital and Medical Center, Phoenix
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Sep 21, 2026, 1:06 AM EDT
Not listed Not applicable Interventional

WoundVac in Obese Patients Undergoing Lumbar Surgery

NCT03688438
View directory record Official record
Conditions
Obesity, Lumbar Spine Surgery
Interventions
Closed-Incision Negative-Pressure Therapy
Device
Lead sponsor
Norton Leatherman Spine Center
Other
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 27, 2018 · Synced Sep 21, 2026, 1:06 AM EDT
Completed Not applicable Interventional

Telehealth Activity Intervention After Lumbar Spine Surgery

NCT04968821
View directory record Official record
Conditions
Spinal Degenerative Disorder
Interventions
Physical activity intervention, Usual care
Behavioral · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 28, 2024 · Synced Sep 21, 2026, 1:06 AM EDT
Completed Not applicable Interventional

A Clinical Study to Evaluate Safety and Performance of PEEK-OPTIMA™ HA Enhanced Interbody Cages in the Lumbar Spine

NCT03928041
View directory record Official record
Conditions
Degenerative Disc Disease Lumbar, Spondylolisthesis, Grade 1
Interventions
Device: EVOS Lumbar Interbody System (EVOS-HA)
Device
Lead sponsor
Invibio Ltd
Industry
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
Charlotte, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Sep 21, 2026, 1:06 AM EDT
Terminated Phase 2 Interventional Results available

Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery

NCT04220489
View directory record Official record
Conditions
Opioid Dependence, Chronic Pain
Interventions
Ketamine, Placebo Comparator
Drug
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years to 70 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 29, 2024 · Synced Sep 21, 2026, 1:06 AM EDT
Completed Phase 4 Interventional Results available

Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery

NCT02063035
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Thoracic Spinal Stenosis
Interventions
Tranexamic Acid, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 7, 2017 · Synced Sep 21, 2026, 1:06 AM EDT
Withdrawn Not applicable Interventional

Erector Spinae Plane Blocks (ESP) for Postoperative Pain in Lumbo-sacral Spine Surgery

NCT04233736
View directory record Official record
Conditions
Erector Spinae Plane Block, Lumbar Spine Surgery
Interventions
Bilateral lumbar erector spinae plane block
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 21, 2026, 1:06 AM EDT
Completed Not applicable Interventional Results available

Study of Opioid Use After Lumbar and Cervical Spine Surgery

NCT02674711
View directory record Official record
Conditions
Low Back Pain, Opiate Addiction, Neck Pain
Interventions
Educational Video
Behavioral
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Sep 21, 2026, 1:06 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

ESP vs QL for Total Abdominal Hysterectomy

NCT04074226
View directory record Official record
Conditions
Postoperative Pain
Interventions
Erector Spinae Plane block, Quadratus Lumborum Block
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 3, 2023 · Synced Sep 21, 2026, 1:06 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Central Nervous System Amplification in Lumbar Failed Back Surgery Syndrome

NCT03444168
View directory record Official record
Conditions
Chronic Pain
Interventions
Not listed
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
22 Years to 70 Years
Enrollment
158 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Sep 21, 2026, 1:06 AM EDT
Terminated Phase 3 Interventional Results available

Comparison of Quadratus Lumborum Block Types

NCT04588389
View directory record Official record
Conditions
Pain, Opioid Use, Lumbar Disc Herniation
Interventions
Ropivacaine injection Location 1, Ropivacaine injection Location 2, Multimodal Pharmacological Management
Drug
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
40 Years to 80 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 27, 2025 · Synced Sep 21, 2026, 1:06 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

The Effectiveness of IV/PO Acetaminophen in the Perioperative Period in Reducing Opiate Use After Lumbar Spine Fusion

NCT03104816
View directory record Official record
Conditions
Fusion of Spine, Lumbar Region
Interventions
Acetaminophen IV Soln 10 MG/ML, Acetaminophen, Hydromorphone
Drug
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2019 · Synced Sep 21, 2026, 1:06 AM EDT
Withdrawn Not applicable Interventional

Proprio Spine Measurement Tool

NCT07023393
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Curvatures, Spinal Osteochondrosis, Spinal Osteophytosis, Spinal Stenosis, Spondylitis, Spondylosis
Interventions
Intraoperative spinal measurement system
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 21, 2026, 1:06 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Oral and Intravenous Tranexamic Acid in Lumbar Spine Surgery

NCT03037515
View directory record Official record
Conditions
Blood Loss, Surgical, Blood Loss Anemia
Interventions
Tranexamic Acid
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 19, 2024 · Synced Sep 21, 2026, 1:06 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cognitive Dysfunction in Hypertensive Patients Having Spine Surgery

NCT01140854
View directory record Official record
Conditions
Hypertension
Interventions
Lumbar spine surgery, Neurologic/neuropsychometric examinations
Procedure · Other
Lead sponsor
Columbia University
Other
Eligibility
60 Years to 90 Years
Enrollment
179 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Sep 21, 2026, 1:06 AM EDT
Active, not recruiting Phase 1 Interventional

Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease

NCT03025256
View directory record Official record
Conditions
Acral Lentiginous Melanoma, Central Nervous System Melanoma, Clinical Stage IV Cutaneous Melanoma AJCC v8, Leptomeningeal Neoplasm, Melanocytoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Melanoma, Metastatic Mucosal Melanoma, Metastatic Uveal Melanoma, Stage IV Lung Cancer AJCC v8
Interventions
Biospecimen Collection, Computed Tomography, Lumbar Puncture, Magnetic Resonance Imaging, Nivolumab, Positron Emission Tomography
Procedure · Biological
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 21, 2026, 1:06 AM EDT
Terminated Phase 4 Interventional Results available

A Study of Intrathecal Hydromorphone for Pediatric Idiopathic Scoliosis Repair

NCT05552443
View directory record Official record
Conditions
Pain Control
Interventions
Hydromorphone 2.5 mcg/kg, Hydromorphone 2.75 mcg/kg, Hydromorphone 3 mcg/kg, Hydromorphone 3.25 mcg/kg, Hydromorphone 3.5 mcg/kg, Hydromorphone 4 mcg/kg, Hydromorphone 4.5 mcg/kg, Hydromorphone 5 mcg/kg, Hydromorphone 5.5 mcg/kg, Hydromorphone 6 mcg/kg, Hydromorphone 6.5 mcg/kg, Hydromorphone 7 mcg/kg
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
10 Years to 17 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 21, 2026, 1:06 AM EDT
Withdrawn Phase 3 Interventional

Peri-Incisional Drug Injection in Lumbar Spine Surgery

NCT03513445
View directory record Official record
Conditions
Lumbar Disc Herniation, Degenerative Disc Disease, Spondylolisthesis
Interventions
Morphine, Epinephrine, naropin
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 18, 2022 · Synced Sep 21, 2026, 1:06 AM EDT
Not listed Phase 1Phase 2 Interventional

Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery

NCT00798902
View directory record Official record
Conditions
Degenerative Disc Disease, Spondylolisthesis
Interventions
Prefix (AMPLEX) B2A Peptide Enhanced Ceramic Granules, Iliac crest autograft
Device · Other
Lead sponsor
BioSurface Engineering Technologies, Inc
Industry
Eligibility
18 Years to 70 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
6
States / cities
Durango, Colorado • Washington D.C., District of Columbia • Kansas City, Kansas + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 8, 2012 · Synced Sep 21, 2026, 1:06 AM EDT
Active, not recruiting Not applicable Interventional

SLIP II Registry: Spinal Laminectomy Versus Instrumented Pedicle Screw Fusion

NCT03570801
View directory record Official record
Conditions
Lumbar Spondylolisthesis, Grade 1 Spondylolisthesis, Lumbar Spinal Stenosis, Degenerative Spondylolisthesis
Interventions
Expert Panel Review
Other
Lead sponsor
Lahey Clinic
Other
Eligibility
18 Years and older
Enrollment
662 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2028
U.S. locations
16
States / cities
Scottsdale, Arizona • San Francisco, California • Miami, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Sep 28, 2025 · Synced Sep 21, 2026, 1:06 AM EDT
Completed Not applicable Interventional Results available

Postoperative Telehealth Mindfulness Intervention After Spine Surgery

NCT04648683
View directory record Official record
Conditions
Chronic Low-back Pain, Postsurgical Pain, Opioid Use, Lumbar Spine Surgery
Interventions
Individual telehealth mindfulness, Group telehealth mindfulness
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 25, 2023 · Synced Sep 21, 2026, 1:06 AM EDT
Terminated Not applicable Interventional

Dynamic Stabilization for Lumbar Spinal Stenosis With Stabilimax NZ® Dynamic Spine Stabilization System

NCT00529997
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Stabilimax NZ® Dynamic Spine Stabilization System
Device
Lead sponsor
Applied Spine Technologies
Industry
Eligibility
21 Years and older
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
19
States / cities
Phoenix, Arizona • Los Angeles, California • Oceanside, California + 16 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2010 · Synced Sep 21, 2026, 1:06 AM EDT