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Showing 25–35 of 11 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Lung Volume Reduction Surgery Clear all
Completed Phase 2 Interventional Results available

Outcomes and Safety Trial Investigating Ecallantide's Effect on Reducing Surgical Blood Loss Volume in Subjects at High Risk of Bleeding Exposed to Cardio-pulmonary Bypass During Cardiac Surgery

NCT00888940
View directory record Official record
Conditions
Bloodloss, Surgical Procedures, Operative
Interventions
Ecallantide, Cyklokapron(R)
Drug
Lead sponsor
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Industry
Eligibility
18 Years to 85 Years
Enrollment
243 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 9, 2015 · Synced Sep 25, 2026, 10:27 AM EDT
Completed Phase 2 Interventional

US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study

NCT00435253
View directory record Official record
Conditions
Pulmonary Emphysema
Interventions
BLVR Treatment
Biological
Lead sponsor
Aeris Therapeutics
Industry
Eligibility
40 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
5
States / cities
Birmingham, Alabama • Phoenix, Arizona • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 23, 2011 · Synced Sep 25, 2026, 10:27 AM EDT
Completed Not applicable Interventional Results available

Lung Volume Reduction for Severe Emphysema by Stereotactic Ablative Radiation Therapy

NCT03673176
View directory record Official record
Conditions
Emphysema
Interventions
Stereotactic Ablative Radiotherapy (SABR)
Radiation
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jul 10, 2024 · Synced Sep 25, 2026, 10:27 AM EDT
Completed Phase 2 Interventional

Cost-Effectiveness of Lung Volume Reduction Surgery

NCT00013156
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease, Emphysema
Interventions
Effectiveness of Lung Reduction Therapy
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
Up to 75 Years · Male only
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2000
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Sep 25, 2026, 10:27 AM EDT
Terminated No phase listed Observational

Evaluating the Effects of Surgical and Non-Surgical Treatment Options in People With Emphysema

NCT00675454
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, Emphysema
Interventions
Not listed
Lead sponsor
Washington University School of Medicine
Other
Eligibility
35 Years to 90 Years
Enrollment
802 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2015
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 1, 2021 · Synced Sep 25, 2026, 10:27 AM EDT
Recruiting Not applicable Interventional

A Multi Center Study Testing a New Implant for Adults With Severe Emphysema

NCT07119229
View directory record Official record
Conditions
Emphysema or COPD, Emphysema, COPD
Interventions
Implantable Artificial Bronchus
Device
Lead sponsor
Pulmair Medical, Inc.
Industry
Eligibility
22 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
San Francisco, California • Chicago, Illinois • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 25, 2026, 10:27 AM EDT
Terminated Phase 3 Interventional

Study of the AeriSeal System for HyPerInflation Reduction in Emphysema (ASPIRE)

NCT01449292
View directory record Official record
Conditions
Pulmonary Emphysema
Interventions
Treatment plus Optimal Medical Therapy, Optimal Medical Therapy
Device · Other
Lead sponsor
Aeris Therapeutics
Industry
Eligibility
40 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
29
States / cities
Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 25 more
Source: ClinicalTrials.gov public record
Updated Nov 13, 2013 · Synced Sep 25, 2026, 10:27 AM EDT
Active, not recruiting No phase listed Observational

Zephyr Valve Registry (ZEVR)

NCT04186546
View directory record Official record
Conditions
Emphysema
Interventions
Zephyr Valve Procedure
Device
Lead sponsor
Pulmonx Corporation
Industry
Eligibility
Not listed
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
11
States / cities
Birmingham, Alabama • Chicago, Illinois • Winfield, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Sep 25, 2026, 10:27 AM EDT
Completed Phase 2 Interventional Results available

Pilot Study of Preoperative Tarceva (Erlotinib) for Stages I/II Non-Small Cell Lung Cancer

NCT00385996
View directory record Official record
Conditions
Carcinoma, Non-small Cell Lung
Interventions
Tarceva (Erlotinib)
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 85 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 27, 2018 · Synced Sep 25, 2026, 10:27 AM EDT
Completed Phase 4 Interventional

Effects of Desflurane and Propofol During Lung Volume Reduction Surgery

NCT04226625
View directory record Official record
Conditions
Lung Volume Reduction Surgery
Interventions
Propofol, Desflurane
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2002
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2020 · Synced Sep 25, 2026, 10:27 AM EDT
Completed Not applicable Interventional

Effect of Low Tidal Volume Ventilation in Improving Oxygenation and Thus Reducing Acute Lung Injury in the Cardiac Surgical Patient

NCT00538161
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome
Interventions
Ventilation strategy
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2017 · Synced Sep 25, 2026, 10:27 AM EDT