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ClinicalTrials.gov public records Last synced Nov 14, 2026, 6:15 PM EST

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Showing 1–24 of 354 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Medication for opioid use disorder Clear all

Conditions: Opioid Use Disorder
Interventions: Extended Visit with Observation, Standard ED Visit; Other
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 100 Years
Enrollment: 170 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 6
States / cities: Newark, New Jersey • Brooklyn, New York • New Hyde Park, New York + 2 more

Conditions: Opioid Use Disorder, HIV Infections, Chlamydia, Gonorrhea, Syphilis, Trichomonas
Interventions: Mobile Van Clinic; Other
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Opioid-Related Disorders
Interventions: Best Practice Health and Employment Opioid-related Policies; Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 99 Years
Enrollment: 4,939 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Opioid Use Disorder, Substance Use Disorder
Interventions: Treatment as Usual (TAU) (Arm 1), Peer Recovery Support Services (PRSS) + TAU (experimental- Arm 2); Behavioral
Lead sponsor: Potomac Health Foundations; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 2
States / cities: Baltimore, Maryland • Rockville, Maryland

Conditions: Opiate Addiction
Interventions: Onsite treatment, Enhanced referral, Buprenorphine; Behavioral · Drug
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 97 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 3
States / cities: New York, New York • The Bronx, New York

Conditions: Opioid Use Disorder (OUD)
Interventions: SL-BUP, XR-BUP, XR-NTX, MM, MMR, MMD; Drug · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 1,516 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 21
States / cities: Little Rock, Arkansas • Tarzana, California • Bridgeport, Connecticut + 17 more

Conditions: Opioid Use Disorder, Posttraumatic Stress Disorder (PTSD)
Interventions: HOPE Therapy; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 70 Years
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Post-Traumatic Stress Disorders, Opiate Use Disorder
Interventions: Buprenorphine, Cognitive Processing Therapy (CPT), Individual Drug Counseling (IDC); Drug · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 2
States / cities: West Haven, Connecticut • Bedford, Massachusetts

Conditions: Drug Use Disorders, Illicit Drug Use, Alcohol-Related Disorders
Interventions: Health Coaching, Practice Facilitation, Standard Implementation; Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years and older
Enrollment: 1,552 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Pain Management, Postoperative Pain
Interventions: Psilocybin (Usona Institute), Postoperative analgesia; Drug
Lead sponsor: Trent Emerick; Other
Eligibility: 25 Years to 65 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2029
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Opioid-Related Disorders, Alcohol-Related Disorders
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 21 Years to 65 Years
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid Use Disorder, Dual Diagnosis, Housing Problems, Mental Disorder in Adolescence, Risk Behavior, Homelessness
Interventions: Motivational Interviewing/Community Reinforcement Approach (MI/CRA), Strengths-Based Outreach and Advocacy (SBOA ), Services as Usual (SAU); Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 14 Years to 24 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 2
States / cities: Columbus, Ohio

Conditions: Maternal Opioid Use Disorder, Opioid Exposed Infant
Interventions: fetal monitoring, Buprenorphine Naloxone; Device · Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 44 Years · Female only
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Digital Intervention, Bibliotherapy
Interventions: Digital technology, Bibliotherapy; Device · Other
Lead sponsor: University of South Carolina; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Contraception
Interventions: SHINE intervention group; Behavioral
Lead sponsor: Denver Health and Hospital Authority; Other
Eligibility: 18 Years to 44 Years · Female only
Enrollment: 119 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Opioid Use Disorder (OUD), Chronic Pain
Interventions: Mindfulness text messages; Behavioral
Lead sponsor: University of New Mexico; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Opioid Use Disorder
Interventions: Intravenous Challenge Drug; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 21 Years to 55 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 2
States / cities: Lexington, Kentucky • New York, New York

Conditions: Opioid-Related Disorders
Interventions: Behavioral: the OPT-IN Intervention; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: HIV Infections, Opioid Use Disorder, Incarceration; Lens
Interventions: Cabotegravir Injection, Cabotegravir Pill, Buprenorphine injection, Buprenorphine Pill; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 450 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse, Drug Abuse, Neonatal Abstinence Syndrome, Neonatal Opiate Withdrawal Syndrome, Drug Abuse in Pregnancy
Interventions: Buprenorphine Injection, Buprenorphine Sublingual Product; Drug
Lead sponsor: T. John Winhusen, PhD; Other
Eligibility: Not listed
Enrollment: 71 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 10
States / cities: Jacksonville, Florida • Boston, Massachusetts • Portland, Oregon + 6 more

Conditions: Healthy Volunteer, Opioid-use Disorder
Interventions: INDV-2000, Placebo, SUBOXONE® sublingual film; Drug
Lead sponsor: Indivior Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 3
States / cities: Baltimore, Maryland • DeSoto, Texas • San Antonio, Texas

Conditions: Anesthesia, Opioid Use
Interventions: Guided mindfulness exercises, Self-administered aromatherapy, Baby aspirin, Tylenol/Acetaminophen, Pregabalin, Prednisone, Meloxicam, Prilosec, Tramadol, Voltaren, Zofran, Pepcid, Reglan, Versed, Lidocaine, Propofol, Ancef, Tranexamic Acid (TXA), Decadron, Bupivacaine hydrochloride, Toradol; Behavioral · Other · Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Opioid Withdrawal (Disorder), Opioid Use Disorder
Interventions: LUCEMYRA (lofexidine) tablets; Drug
Lead sponsor: USWM, LLC (dba US WorldMeds); Industry
Eligibility: 12 Years to 18 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid-Use Disorder
Interventions: Placebo, TRV734, Oxycodone; Other · Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 75 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Baltimore, Maryland

Search by objective public record fields.

ED Observation for Opioid Use Disorder

Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washington

Improving Health and Employment Outcomes Through Workplace Opioid Policies

Peer Recovery Support Services for Individuals in Recovery Residences on MOUD

Onsite Buprenorphine Treatment at Syringe Exchange Programs

Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)

Integrated Treatment for Opioid Use Disorder and PTSD

Optimal Treatment of Veterans With PTSD and Comorbid OUD

An Initial Study of the Implementation of Digital Therapeutics for Substance Use Disorders in Primary Care

Psilocybin After Trauma Surgery for Pain

Imaging Biomarker for Addiction Treatment Outcome

Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness

Maternal Buprenorphine-naloxone Treatment and the Infant

Digital Support Intervention for Pregnant People with Opioid Use Disorders

Improving Reproductive Health for Women in Opioid Medication-Assisted Treatment (OMAT)

Opioid Adherence and Support Through Innovative Texting Strategies

A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists.

The OPT-IN Project

NOTRE: Optimizing Long-Acting Pre-Exposure Prophylaxis and Medications for Opioid Use Disorder Interventions in Carceral Settings

Medication Treatment for Opioid Use Disorder in Expectant Mothers: Infant Neurodevelopmental Outcomes Sub-study

Study to Assess Repeated Doses of INDV-2000 in Healthy Volunteers and in Treatment Seeking Individuals With Opioid Use Disorder

PROUD Study - Preventing Opioid Use Disorders

A Pharmacokinetic, Safety, and Tolerability Study of LUCEMYRA in the Treatment of Opioid Withdrawal Management in Adolescent Subjects

Biased Opioid Agonists for Treatment of Opioid Withdrawal in OUD