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ClinicalTrials.gov public records Last synced Oct 3, 2026, 12:58 PM EDT

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Showing 73–96 of 352 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Medications for Opioid Use Disorder Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Craving & Decision-Making

NCT06440577
View directory record Official record
Conditions
Decision Making
Interventions
Audio-visual stimuli (Neutral-Relaxing), Audio-visual stimuli (Drug), Audio-visual stimuli (Non-Food), Audio-visual stimuli (Food)
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 3, 2026, 12:58 PM EDT
Terminated Phase 1 Interventional

Acute Pain Management in Patients on Opioid Replacement Therapy

NCT03933865
View directory record Official record
Conditions
Opioid-use Disorder, Pain, Acute
Interventions
HYDROmorphone Injectable Solution, Ketamine, Placebos
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 60 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 10, 2022 · Synced Oct 3, 2026, 12:58 PM EDT
Active, not recruiting Not applicable Interventional

Promoting HIV Risk Reduction Among People Who Inject Drugs: A Stepped Care Approach Using Contingency Management With PrEP Adherence and Support Services

NCT04738825
View directory record Official record
Conditions
Opioid-use Disorder, HIV Prevention Program
Interventions
Contingency Management with stepped care to PrEP adherence and support services (CoMPASS)
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
526 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
6
States / cities
Bridgeport, Connecticut • Danbury, Connecticut • New Haven, Connecticut + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 3, 2026, 12:58 PM EDT
Recruiting Not applicable Interventional

The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care

NCT06837662
View directory record Official record
Conditions
Opioid Dependence, Substance Abuse Disorders, Complex Medical Patients, Primary Care Patients With Chronic Conditions
Interventions
MOUD "Plus" Intervention (treatment as usual + coordinated counseling and referral to community based peer), Treatment As Usual (primary care with low threshold MOUD prescribing)
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 25, 2026 · Synced Oct 3, 2026, 12:58 PM EDT
Completed Not applicable Interventional

Effect of Music on Cue Reactivity for Patients With Opioid Use Disorder

NCT06948890
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Music intervention, Silence
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Oct 3, 2026, 12:58 PM EDT
Completed Not applicable Interventional Results available

Effectiveness of Opiate Replacement Therapy Administered Prior to Release From a Correctional Facility - 1

NCT00142935
View directory record Official record
Conditions
HIV Prevention, Opioid-Related Disorders
Interventions
Pre-release Initiation of MMT, Post Release Initiation of MMT., Standard of Care Plus
Behavioral
Lead sponsor
The Miriam Hospital
Other
Eligibility
18 Years and older
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 6, 2014 · Synced Oct 3, 2026, 12:58 PM EDT
Completed Not applicable Interventional

Enhancing Permanency in Children and Families

NCT04700696
View directory record Official record
Conditions
Substance Abuse, Substance Use, Child Abuse, Neglect, Child
Interventions
Peer Recovery Support, Family Treatment Drug Court with Medications for Opioid Use Disorders (MOUD), Relational Skill Building based on the Nurturing Parenting Program (NPP)
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
Not listed
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Oct 3, 2026, 12:58 PM EDT
Recruiting Phase 3 Interventional

Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3

NCT05834478
View directory record Official record
Conditions
Withdrawal Symptoms, Opioid Use Disorder, Opioid Use
Interventions
Transcutaneous Cervical Vagal Nerve Stimulation, Sham Stimulation, [F-18]Fallypride
Device · Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 75 Years
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
6
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 3, 2026, 12:58 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Pilot Study to Evaluate Skin Swabbing With Chlorhexidine to Prevent Skin And Soft Tissue Infections Among People Who Inject Drugs

NCT06733506
View directory record Official record
Conditions
Opioid Use Disorder, Injection Drug Use, Skin and Soft Tissue Infections (SSTIs)
Interventions
Chlorhexidine gluconate, Isopropyl Alcohol 70% Topical Application Solution, Skin Prep Before Injecting Recreational/Street Drugs
Drug · Behavioral
Lead sponsor
Gabriel John Culbert
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 3, 2025 · Synced Oct 3, 2026, 12:58 PM EDT
Active, not recruiting Not applicable Interventional

IMPOWR-ME Project 1: Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs

NCT05492825
View directory record Official record
Conditions
Substance Use Disorders, Chronic Pain, Opioid Use Disorder, Back Pain Lower Back Chronic
Interventions
Yoga, Physical Therapy, Treatment As Usual
Other
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Oct 3, 2026, 12:58 PM EDT
Completed Phase 4 Interventional

Integrating Buprenorphine Into the SFGH AIDS Program

NCT00263458
View directory record Official record
Conditions
HIV, Buprenorphine, Opioid Dependence
Interventions
Integrated office-based buprenorphine treatment for opioid dependence in an HIV primary care setting
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
19 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 12, 2011 · Synced Oct 3, 2026, 12:58 PM EDT
Completed Not applicable Interventional Results available

Community Trial in the Cherokee Nation

NCT04839978
View directory record Official record
Conditions
Opioid Abuse
Interventions
Connect Program, Communities Mobilizing for Change and Action (CMCA)
Behavioral
Lead sponsor
Emory University
Other
Eligibility
15 Years to 17 Years
Enrollment
919 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Tahlequah, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Oct 3, 2026, 12:58 PM EDT
Completed Not applicable Interventional

Genomic Opioid Optimization of Dosing and Selections (GOODS) Study

NCT03579121
View directory record Official record
Conditions
Perioperative/Postoperative Complications
Interventions
Pharmacogenomic (PGx), Review results
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Oct 3, 2026, 12:58 PM EDT
Terminated Phase 1 Interventional

Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).

NCT06406400
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
AZD4041, Itraconazole, Buprenorphine, Buprenorphine / Naloxone, Hydromorphone, Placebo
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Oct 3, 2026, 12:58 PM EDT
Withdrawn Phase 2 Interventional

Novel Non-opioid Post-surgical Pain Treatment in Females

NCT05087914
View directory record Official record
Conditions
Acute Pain, Bunionectomy, Toe Fusion
Interventions
Carbidopa-Levodopa (100mg/25mg):, Naproxen
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 75 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 18, 2024 · Synced Oct 3, 2026, 12:58 PM EDT
Not yet recruiting Phase 4 Interventional

Comparing Outpatient Treatment Retention Among Individuals Using Fentanyl Randomized to Low-dose and Direct-to-inject Buprenorphine Initiation

NCT07469501
View directory record Official record
Conditions
Opioid Use Disorder, Fentanyl
Interventions
Injectable buprenorphine, Sublingual Buprenorphine (SUBOXONE, Zubsolv, or generic tablets)
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 3, 2026, 12:58 PM EDT
Completed Phase 4 Interventional Results available

Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients

NCT02432456
View directory record Official record
Conditions
Wounds and Injuries, Rib Fractures
Interventions
Ketamine, Placebo, Intercostal Nerve Block, Acetaminophen, Ibuprofen, Pantoprazole, Methocarbamol, Opioid
Drug · Procedure
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 5, 2020 · Synced Oct 3, 2026, 12:58 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Assessment of Methadone and Buprenorphine in Interstitial Fluid

NCT05546229
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Microneedle based interstitial fluid collection
Procedure
Lead sponsor
Cari Health Inc.
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Lemon Grove, California
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Oct 3, 2026, 12:58 PM EDT
Completed Not applicable Interventional Results available

FOREward Together: Training Peer Recovery Coaches to Promote Retention and Adherence to MOUD

NCT05098795
View directory record Official record
Conditions
Opioid Use
Interventions
Behavioral Activation (BA)
Behavioral
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 14, 2025 · Synced Oct 3, 2026, 12:58 PM EDT
Completed Not applicable Interventional

Pre-exposure Prophylaxis (PrEP) Rapid Access

NCT05528562
View directory record Official record
Conditions
Drug Use, Pre-exposure Prophylaxis (PrEP), Opioid Use Disorder
Interventions
PrEP Rapid Access, HIV self-testing, Dried blood spot testing
Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 16, 2024 · Synced Oct 3, 2026, 12:58 PM EDT
Completed Not applicable Interventional

Automated Recovery Line for Medication Assisted Treatment

NCT02124980
View directory record Official record
Conditions
Drug Dependence, Substance Use Disorders
Interventions
Recovery Line
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 3, 2026, 12:58 PM EDT
Terminated Not applicable Interventional

Reactive vs. Proactive Pain Control in IBD

NCT03798405
View directory record Official record
Conditions
Inflammatory Bowel Diseases, Pain, Opioid Use, Crohn Disease, Ulcerative Colitis
Interventions
Proactive Analgesic Inpatient Narcotic-Sparing
Behavioral
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 22, 2022 · Synced Oct 3, 2026, 12:58 PM EDT
Recruiting Not applicable Interventional

Sparrow Link Neuromodulation Device for Opioid Withdrawal Management in Hospitalized Adults With Opioid Use Disorder

NCT07079826
View directory record Official record
Conditions
Opioid Withdrawal, Opioid Use Disorder (OUD)
Interventions
Sparrow Link (Active tAN), Sparrow Link (Sham tAN)
Device
Lead sponsor
Payel Roy
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Oct 3, 2026, 12:58 PM EDT
Completed Not applicable Interventional

Combining Opioid Addiction Treatment Services With CARe for Infectious Endocarditis

NCT03048643
View directory record Official record
Conditions
Endocarditis, Bacterial, Opioid-use Disorder, Buprenorphine, Outpatient Parenteral Antibiotic Therapy
Interventions
Outpatient parenteral antibiotic therapy
Behavioral
Lead sponsor
Laura Fanucchi
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 23, 2019 · Synced Oct 3, 2026, 12:58 PM EDT