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ClinicalTrials.gov public records Last synced Oct 20, 2026, 2:30 PM EDT

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Showing 1–24 of 70 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Menthol Cigarette Smoking Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers

NCT07598136
View directory record Official record
Conditions
Smoking, Tobacco
Interventions
P2613422, P2611222, P2615522, P2615122, P2615422
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 65 Years
Enrollment
1,280 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
7
States / cities
Maitland, Florida • Atlanta, Georgia • St Louis, Missouri + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Characterization of Product Use in Smokers Switching From Cigarettes to a RELX Electronic Nicotine Delivery System

NCT04708106
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, RELX ENDS Tobacco and Menthol Flavors
Other
Lead sponsor
Cheerain HK Limited
Industry
Eligibility
22 Years to 65 Years
Enrollment
194 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
5
States / cities
Bentonville, Arkansas • Lexington, Kentucky • Springfield, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2021 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Effects of Menthol in E-cigarettes on Smoking Behaviors

NCT04521647
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Biomarkers of Exposure and Biomarkers of Potential Harm in Adult Smokers Who Completely Switch to E-vapor Products

NCT04800211
View directory record Official record
Conditions
Tobacco Use
Interventions
Experimental: Test Product 1, Experimental: Test Product 2
Other
Lead sponsor
Altria Client Services LLC
Industry
Eligibility
30 Years to 65 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
10
States / cities
Burbank, California • Wichita, Kansas • Lexington, Kentucky + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2025 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating the Impact of Synthetic Cooling Agents in Combustible Cigarettes on Smoking Perceptions and Use

NCT06230159
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Non-menthol Cigarette Smoking, Menthol Cigarette Smoking, Synthetic Cooling Agent Cigarette Smoking, Usual Brand Cigarette Smoking, Spirometry, Questionnaire Administration, Nasal Epithelial Lining Fluid
Behavioral · Diagnostic Test · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 29 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

A RCT to Determine the Effect of ENDS Flavor Availability on Abstinence Within Smokers

NCT07172438
View directory record Official record
Conditions
Smoking, Tobacco
Interventions
P2611222, P2615022, P2615122, P2613422
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 65 Years
Enrollment
668 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
27
States / cities
Chandler, Arizona • Fort Smith, Arkansas • Altamonte Springs, Florida + 21 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users

NCT02102100
View directory record Official record
Conditions
Nicotine Dependence
Interventions
nicotine, menthol
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 30 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 19, 2020 · Synced Oct 20, 2026, 2:30 PM EDT
Not listed Not applicable Interventional

Using ANDS to Reduce Harm for Low SES Cigarette Smokers

NCT05327439
View directory record Official record
Conditions
Smoking, Cigarette, Nicotine Dependence
Interventions
Nicotine (electronic cigarette), Nicotine (nicotine pouch)
Other
Lead sponsor
Brown University
Other
Eligibility
21 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 26, 2023 · Synced Oct 20, 2026, 2:30 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

DoubleTake: Effect of Message Exposure Via a Discrete Choice Experiment With Eye-Tracking on Quit Attempts Among Adults Who Smoke Menthol Cigarettes

NCT07782879
View directory record Official record
Conditions
Menthol Cigarettes, Smoking Behavior, Cigarette Use
Interventions
Message Exposure via Discrete Choice Experiment
Behavioral
Lead sponsor
Georgia State University
Other
Eligibility
21 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
2
States / cities
Santa Barbara, California • Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder

NCT02990455
View directory record Official record
Conditions
Alcohol Drinking, Cigarette Smoking Toxicity
Interventions
Reduced nicotine cigarettes
Drug
Lead sponsor
Battelle Memorial Institute
Other
Eligibility
21 Years to 65 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 29, 2021 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Delivery From Novel Non-Tobacco Electronic System in Smokers

NCT02575885
View directory record Official record
Conditions
Cigarette Smoker, Current Smoker, Healthy Subject
Interventions
Electronic Cigarette, Laboratory Biomarker Analysis, Pharmacological Study, Questionnaire Administration
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years to 55 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 12, 2018 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Results available

Smoking Cessation in Menthol Flavored Cigarette Smokers

NCT02342327
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
switch to non-menthol cigarettes prior to cessation attempt, continue smoking menthol cigarettes prior to cessation attempt
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 64 Years
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 28, 2021 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to JUUL ENDS

NCT04107779
View directory record Official record
Conditions
Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
Interventions
Switch from UB of Combustible Cigarette to JUUL 5% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Mint ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Mint ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Menthol ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Menthol ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Mango ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Mango ENDS, Switch to Dual-use of JUUL 5% and UB of Combustible Cigarette, Tobacco/Nicotine Abstention, Usual Brand of cigarettes
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
279 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
5
States / cities
Little Rock, Arkansas • Rogers, Arkansas • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Menthol and Mint Experimental Tobacco Marketplace (ETM) Study

NCT04879225
View directory record Official record
Conditions
Cigarette Smoking, Vaping
Interventions
Tobacco e-liquids, Menthol and Tobacco e-liquids, Mint, Menthol and Tobacco e-liquids, All e-liquid flavors
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Oct 20, 2026, 2:30 PM EDT
Recruiting Not applicable Interventional

UNC Tobacco Convenience Store

NCT07458607
View directory record Official record
Conditions
Health Behavior
Interventions
Menthol ban + campaign, Menthol ban, Control
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
21 Years and older
Enrollment
1,185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes

NCT05383508
View directory record Official record
Conditions
Nicotine Vaping, Nicotine, Vaping
Interventions
CA35, CM35, Cig
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
24 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 26, 2024 · Synced Oct 20, 2026, 2:30 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of Short-term Safety and Use Patterns of an Electronic Nicotine Delivery System

NCT01898169
View directory record Official record
Conditions
Nicotine Dependence
Interventions
NJOY King 26 mg nicotine Electronic Nicotine Delivery System
Other
Lead sponsor
LA Clinical Trials
Other
Eligibility
18 Years to 65 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Burbank, California
Source: ClinicalTrials.gov public record
Updated Jul 12, 2013 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

BRP1602: Evaluation of Technical and Logistical Feasibility to Measure Lung Permeability

NCT06105424
View directory record Official record
Conditions
Tobacco Use, Smoking, Smoking, Tobacco
Interventions
Lung Permeability Assessment
Procedure
Lead sponsor
RAI Services Company
Industry
Eligibility
30 Years to 50 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Oct 27, 2023 · Synced Oct 20, 2026, 2:30 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers

NCT07710820
View directory record Official record
Conditions
Smoking, Tobacco
Interventions
31237616, 31237617, 31237571, 31237581
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 65 Years
Enrollment
1,060 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
9
States / cities
Brandon, Florida • Coral Springs, Florida • Aurora, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Results available

Pharmacokinetic and Subjective Effects of Heated Tobacco Products

NCT06356610
View directory record Official record
Conditions
Tobacco Use
Interventions
Product A, Product B, Product C, Product D, Product E, Product F
Other
Lead sponsor
Altria Client Services LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
3
States / cities
Lexington, Kentucky • Springfield, Missouri • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cooling Agent Pilot Among Adult Menthol Smokers

NCT06477601
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Assigning cooling agent type cigarettes, Assigning traditional tobacco type cigarettes, Assigning menthol type cigarettes
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 6, 2025 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Results available

Impact of Switching to Non-Menthol Cigarettes Among Smokers

NCT03075839
View directory record Official record
Conditions
Tobacco Use
Interventions
Cigarette Brand Switching
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 2, 2023 · Synced Oct 20, 2026, 2:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of E-Cigarettes in Menthol Smokers

NCT05949034
View directory record Official record
Conditions
E-cigarette Use, Smoking Behaviors
Interventions
JUUL E-Cigarette Device
Device
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 20, 2023 · Synced Oct 20, 2026, 2:30 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

NCT06372899
View directory record Official record
Conditions
E-cigarette Use, Cigarette Smoking, Harm Reduction, Tobacco Use
Interventions
E-cigarettes, Oral nicotine pouches
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
21 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Oct 20, 2026, 2:30 PM EDT