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Showing 1–24 of 27 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Misoprostol Alone Clear all
Completed Phase 3 Interventional

Different Medications to Induce Labor

NCT06259097
View directory record Official record
Conditions
Pregnancy, Labor
Interventions
Misoprostol, Pitocin
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older · Female only
Enrollment
303 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 3, 2026, 4:42 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

BMI-Associated Labor Induction: A Prospective Trial

NCT04035382
View directory record Official record
Conditions
Labor Induction
Interventions
Labor induction
Procedure
Lead sponsor
Baystate Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
2
States / cities
Springfield, Massachusetts • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 12, 2022 · Synced Sep 3, 2026, 4:42 PM EDT
Completed No phase listed Observational

Misoprostol for Spinal Stenosis

NCT04611464
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Low Back Pain
Interventions
Misoprostol
Drug
Lead sponsor
Dallas VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 1, 2020 · Synced Sep 3, 2026, 4:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparing Misoprostol Alone to Dilapan With Misoprostol and Comparing Buccal to Vaginal Misoprostol

NCT02363556
View directory record Official record
Conditions
Second Trimester Abortions
Interventions
Misoprostol administered vaginally, Misoprostol administered buccally, Misoprostol administered vaginally with Dilapan, Misoprostol administered buccally with Dilapan
Procedure
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 29, 2017 · Synced Sep 3, 2026, 4:42 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Labor Protocol Study

NCT04004845
View directory record Official record
Conditions
Vaginal Delivery, Labor, Induced; Birth
Interventions
Cytotec, oxytocin, Cervical Foley Balloon
Drug · Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 3, 2022 · Synced Sep 3, 2026, 4:42 PM EDT
Completed Phase 4 Interventional Results available

Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial

NCT05322252
View directory record Official record
Conditions
Abortion, Second Trimester, PPROM, Rupture, Spontaneous, Fetal Demise, Fetal Death, Fetal Demise From Miscarriage, Fetal Death Before 22 Weeks With Retention of Dead Fetus, Pregnancy Loss, Pregnancy Complications
Interventions
Mifepristone, Misoprostol
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 3, 2026, 4:42 PM EDT
Not yet recruiting Not applicable Interventional

Is Nipple Stimulation Effective for Inducing Labor and Acceptable to Patients, Nurses, and Providers?

NCT07588529
View directory record Official record
Conditions
Pregnancy, Induction of Labor
Interventions
Electric breast pump for nipple stimulation, induction of labor
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 3, 2026, 4:42 PM EDT
Completed Phase 3 Interventional Results available

Comparative Effectiveness of Pregnancy Failure Management Regimens

NCT02012491
View directory record Official record
Conditions
Spontaneous Abortion
Interventions
Misoprostol, Mifepristone
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
3
States / cities
Sacramento, California • The Bronx, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Sep 3, 2026, 4:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cervical Ripening in Premature Rupture of Membranes

NCT02314728
View directory record Official record
Conditions
Pregnancy, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Unfavorable Cervix
Interventions
Misoprostol, Oxytocin
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
15 Years to 50 Years · Female only
Enrollment
230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 9, 2021 · Synced Sep 3, 2026, 4:42 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Letrozole and Misoprostol for Termination of Pregnancy up to 63 Days' Gestation

NCT05207644
View directory record Official record
Conditions
Pregnancy
Interventions
30 mg letrozole followed by 800 mcg misoprostol
Drug
Lead sponsor
Gynuity Health Projects
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 14, 2022 · Synced Sep 3, 2026, 4:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Elective Induction of Nulliparous Labor

NCT01076062
View directory record Official record
Conditions
Pregnancy
Interventions
Induction of Labor
Procedure
Lead sponsor
Madigan Army Medical Center
Federal
Eligibility
18 Years to 40 Years · Female only
Enrollment
162 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2017
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Sep 3, 2026, 4:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cervical Preparation Before Dilation and Evacuation

NCT01751087
View directory record Official record
Conditions
Abortion, Induced
Interventions
Mifepristone, misoprostol, Osmotic dilators, placebo
Other · Drug · Device
Lead sponsor
Planned Parenthood League of Massachusetts
Other
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
7
States / cities
San Francisco, California • Chicago, Illinois • Boston, Massachusetts + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 23, 2016 · Synced Sep 3, 2026, 4:42 PM EDT
Completed Not applicable Interventional Results available

Foley OR MisO for the Management of Induction

NCT01916681
View directory record Official record
Conditions
Delivery; Prolonged
Interventions
Cervical Foley & Misoprostol, Misoprostol Alone, Cervical Foley Alone, Cervical Foley & Pitocin
Device · Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
491 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 17, 2017 · Synced Sep 3, 2026, 4:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Randomized Comparison of Transcervical Foley Bulb With Vaginal Misoprostol to Vaginal Misoprostol Alone for Induction of Labor

NCT02566005
View directory record Official record
Conditions
Pregnancy
Interventions
misoprostol, Foley bulb
Device
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 26, 2018 · Synced Sep 3, 2026, 4:42 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Atorvastatin as a Potential Adjunct to Misoprostol for Termination of Pregnancy

NCT05342974
View directory record Official record
Conditions
Abortion Early
Interventions
Atorvastatin, Misoprostol
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Sep 3, 2026, 4:42 PM EDT
Not yet recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

Impact of Standardization on Outcomes Following Cervical Ripening

NCT07576881
View directory record Official record
Conditions
Pregnancy
Interventions
Cervical Ripening with a double balloon catheter only, Cervical ripening with a double balloon catheter plus misoprostol, Usual-care control group
Device · Combination Product
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older · Female only
Enrollment
1,158 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 3, 2026, 4:42 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

Missed Period Pill Study

NCT04940013
View directory record Official record
Conditions
Menstrual Regulation, Menstrual Irregularity
Interventions
Misoprostol
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Female only
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Jan 19, 2026 · Synced Sep 3, 2026, 4:42 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial

NCT02639429
View directory record Official record
Conditions
Obesity, Labor Induction, Cesarean Delivery
Interventions
Vaginal Misoprostol, Foley Balloon + Vaginal Misoprostol
Drug · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older · Female only
Enrollment
236 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 25, 2019 · Synced Sep 3, 2026, 4:42 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Mifepristone vs Misoprostol

NCT06502158
View directory record Official record
Conditions
Cervical Preparation
Interventions
Mifepristone, Misoprostol
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 3, 2026, 4:42 PM EDT
Terminated Not applicable Interventional Results available

Outpatient Foley Catheter Compared to Usual Inpatient Care for Labor Induction

NCT02546193
View directory record Official record
Conditions
Pregnancy
Interventions
Foley catheter, Misoprostol
Device · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 19, 2019 · Synced Sep 3, 2026, 4:42 PM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Mifepristone and Misoprostol for Undesired Pregnancy of Unknown Location

NCT05839899
View directory record Official record
Conditions
Abortion
Interventions
Mifepristone plus one dose Misoprostol, Mifepristone plus two doses Misoprostol
Drug
Lead sponsor
Planned Parenthood League of Massachusetts
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 4, 2023 · Synced Sep 3, 2026, 4:42 PM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers Results available

Prophylactic Analgesic and Antiemetic Regimen for Medical Abortion < 70 Days

NCT05819619
View directory record Official record
Conditions
Nausea, Pain
Interventions
Prophylactic use of ibuprofen and ondansetron post misoprostol administration, Use of ibuprofen and ondansetron at symptom onset post misoprostol administration
Drug
Lead sponsor
Hackensack Meridian Health
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Hackensack, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 16, 2025 · Synced Sep 3, 2026, 4:42 PM EDT
Not listed Phase 4 Interventional

Oxytocin Bolus Versus Infusion in Elective Cesarean Section"

NCT05236985
View directory record Official record
Conditions
Elective Cesarean Section
Interventions
Oxytocin bolus or oxytocin infusion
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Mar 14, 2024 · Synced Sep 3, 2026, 4:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cervical Foley Plus Vaginal Misoprostol for Labor Induction

NCT01279343
View directory record Official record
Conditions
Induction of Labor
Interventions
Foley bulb
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 2, 2019 · Synced Sep 3, 2026, 4:42 PM EDT