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Conditions: Parkinson Disease, Dysarthria
Interventions: Remote speech rehabilitation; Behavioral
Lead sponsor: Florida State University; Other
Eligibility: 25 Years to 85 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Tallahassee, Florida

Conditions: Familial Cold Autoinflammatory Syndrome (FCAS), Familial Cold Urticaria, Muckle-Wells Syndrome (MWS), Genetic Diseases, Inborn
Interventions: rilonacept 160 mg, Placebo; Drug
Lead sponsor: Regeneron Pharmaceuticals; Industry
Eligibility: 7 Years and older
Enrollment: 104 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 24
States / cities: Little Rock, Arkansas • Palm Desert, California • Upland, California + 21 more

Conditions: Acid Sphingomyelinase Deficiency, Ceroid Lipofuscinosis, Neuronal, 2, Cerebrotendinous Xanthomatosis, Fabry Disease, GM1 Gangliosidosis, Gaucher Disease, Lysosomal Acid Lipase Deficiency, Metachromatic Leukodystrophy, Mucopolysaccharidosis II, Mucopolysaccharidosis III-B, Mucopolysaccharidosis IV A, Mucopolysaccharidosis VI, Mucopolysaccharidosis VII, Niemann-Pick Disease, Type C
Interventions: Confirmatory Testing; Diagnostic Test
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: Up to 4 Weeks
Enrollment: 100,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2029
U.S. locations: 9
States / cities: Brooklyn, New York • Manhasset, New York • New York, New York + 2 more

Conditions: Psychosis
Interventions: CALMS; Behavioral
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 12 Years to 30 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pancreas Cancer, Peutz-Jeghers Syndrome (PJS), Gene Mutation, Germline Mutation Carrier, Lynch Syndrome
Interventions: Secretin, MRI, Tumor marker gene test with CA19-9; Drug · Diagnostic Test · Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 9,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2029
U.S. locations: 9
States / cities: New Haven, Connecticut • Baltimore, Maryland • Boston, Massachusetts + 5 more

Conditions: Multiple Chronic Conditions, Family Members
Interventions: "My Health Priorities" Identification Program; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 65 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Obesity, Overweight, Weight Loss
Interventions: Physician Counseling, Health Educator, Phone Counseling, Health promotion materials on physical activity and nutrition; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 11 Years to 13 Years
Enrollment: 106 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Diabetes, Diabetes Mellitus, Type 2
Interventions: Insulin detemir, Insulin NPH, Diet/exercise; Drug · Behavioral
Lead sponsor: Novo Nordisk A/S; Industry
Eligibility: 10 Years to 18 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 23
States / cities: Tucson, Arizona • Los Angeles, California • Jacksonville, Florida + 19 more

Conditions: Prostate Cancer
Interventions: Questioners, blood specimens, prostate tissue specimens; Other
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 35 Years and older · Male only
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 2
States / cities: Los Angeles, California • New York, New York

Conditions: HIV/AIDS
Interventions: Group Cognitive Behavioral Therapy (G-CBT), Multiple Family Group (MFG); Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 10 Years to 14 Years
Enrollment: 89 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Pulmonary Arterial Hypertension, Pulmonary Hypertension, PAH WHO Group I
Interventions: Sitaxsentan, Bosentan, Ambrisentan; Drug
Lead sponsor: West Penn Allegheny Health System; Other
Eligibility: Not listed
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2012
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Caregiver Burden of People With Dementia
Interventions: Skill-building classes, Wait list control group; Other
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years to 100 Years
Enrollment: 225 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Mood Disorders
Interventions: Multifamily Psychoeducation Group (MFPG), Treatment as usual (TAU); Behavioral
Lead sponsor: Mary Fristad; Other
Eligibility: 8 Years to 11 Years
Enrollment: 165 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2006
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Substance Abuse, Families, Trauma
Interventions: Multidimensional Family Therapy, Group CBT; Other
Lead sponsor: University of Miami; Other
Eligibility: 13 Years to 17 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2010
U.S. locations: 2
States / cities: Miami, Florida • Luling, Louisiana

Conditions: Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Relatives to/Carers of Patients, Healthcare Professionals
Interventions: No treatment given; Other
Lead sponsor: Novo Nordisk A/S; Industry
Eligibility: 18 Years and older
Enrollment: 8,985 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012
U.S. locations: 1
States / cities: Princeton, New Jersey

Conditions: Ovarian Cancer, Epithelial, Peritoneal Cancer, Fallopian Tube Cancer
Interventions: Streamlined Education, Traditional Education; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use, Opioid Use Disorder, Drug Overdose, Overdose Prevention, Co-occurring Mental Health Conditions
Interventions: Practice Companion; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 14 Years to 24 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2027 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Alcohol Abuse, Alcohol Use Disorder, Alcohol Drinking, Relations, Interpersonal, Military Family
Interventions: CRAFT Web-Based Intervention, Phone-Based CRAFT, CRAFT Workbook, Gottman Self-Guided Resources; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 744 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Myelodysplastic and Myeloproliferative Disorders, Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, Multiple Myeloma, Plasma Cell Dyscrasia, Lymphoproliferative Disorders, Hematologic Diseases
Interventions: Campath, Busulfan, Fludarabine, Hematopoietic stem cell infusion, FK-506; Drug · Procedure
Lead sponsor: Baylor College of Medicine; Other
Eligibility: Up to 70 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 2
States / cities: Houston, Texas

Conditions: Atopic Dermatitis
Interventions: Routine Care/Education, Psychoeducation/Coping Prevention; Other · Behavioral
Lead sponsor: Seton Healthcare Family; Other
Eligibility: 2 Months to 12 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Breast Neoplasms
Interventions: Allogeneic GM-CSF-secreting breast cancer vaccine, Trastuzumab, Cyclophosphamide; Biological · Drug
Lead sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Other
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Obesity, Childhood
Interventions: Telehealth group sessions, Empower clinic; Behavioral
Lead sponsor: Children's Hospital Los Angeles; Other
Eligibility: 14 Years to 18 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Integrating Behavioral Health
Interventions: Software; Other
Lead sponsor: Medical Decision Logic, Inc.; Industry
Eligibility: Not listed
Enrollment: 16,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 2
States / cities: Connersville, Indiana • Philadelphia, Pennsylvania

Conditions: Lung Cancer, Genetic Disease, Genetic Predisposition, Hereditary Diseases
Interventions: Data and Specimen Collection; Genetic
Lead sponsor: Dana-Farber Cancer Institute; Other
Eligibility: 18 Years and older
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 2
States / cities: Boston, Massachusetts

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Dysarthria Management for Minor Groups

Rilonacept for Treatment of Cryopyrin-Associated Periodic Syndromes (CAPS)

ScreenPlus: A Comprehensive, Flexible, Multi-disorder Newborn Screening Program

Computer-Aided Learning for Managing Stress

The Cancer of the Pancreas Screening-5 CAPS5)Study

Black Health Identification Program (B-HIP)

PACE-PC: Primary Care Management of Adolescent Obesity

A Trial Investigating the Efficacy and Safety of Insulin Detemir Versus Insulin NPH in Combination With Metformin and Diet/Exercise in Children and Adolescents With Type 2 Diabetes Insufficiently Controlled on Metformin With or Without Other Oral Antidiabetic Drug(s) With or Without Basal Insulin

Prostate Biomarker Study

Suubi4Stigma: Addressing HIV-Associated Stigma Among Adolescents

Pharmacogenomics in Pulmonary Arterial Hypertension

Demonstrating the Efficacy of a Spanish-Language Program for Latino Dementia Caregivers

Family Psychoeducation for Children With Mood Disorders

Family-Based Drug Services for Young Disaster Victims

Diabetes Attitudes Wishes and Needs

Prospective Randomized Trial of Streamlined Genetic Education and Testing for Ovarian Cancer Patients

Clinician Practice Companion to Address Youth Substance Use

A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners

Reduced Intensity Preparative Regimen Followed by Stem Cell Transplant (FAB)

A Psychoeducational Prevention for the Treatment of Atopic Dermatitis in Youth and Their Families

Trastuzumab, Cyclophosphamide, and an Allogeneic GM-CSF-secreting Breast Tumor Vaccine for the Treatment of HER-2/Neu-Overexpressing Metastatic Breast Cancer

Group Telehealth Weight Management Visits for Adolescents With Obesity

Web Platform to Integrate Behavioral Health

Investigating Hereditary Risk In Thoracic Cancers (INHERIT)