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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: NPWT Clear all
Recruiting Early Phase 1 Interventional

Micro/Nanobubbles (MNBs) for Treatment of Acute and Chronic Wounds

NCT05169814
View directory record Official record
Conditions
Open Wound, Wound Heal
Interventions
Micro/nanobubble (MNB) - Irrigation, 0.9% Normal Saline - Irrigation, Micro/nanobubble (MNB) - Negative Pressure Wound Therapy with Instillation (NPWTi), 0.9% Normal Saline - Negative Pressure Wound Therapy with Instillation (NPWTi)
Drug · Other
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Sep 8, 2026, 2:32 PM EDT
Not listed Not applicable Interventional

A Comparative Study to Assess the Prevention of Surgical Site Infection (SSI's) in Revision Total Joint Arthroplasty Patients Treated With Single-Use Negative Pressure Wound Therapy (PICO™) or Standard Care Dressings (AQUACEL® Ag SURGICAL Dressing)

NCT02664168
View directory record Official record
Conditions
Surgical Wound Infection
Interventions
Aquacel Ag Surgical Dressing, Single-Use Negative Pressure Wound Therapy (PICO)
Device
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 11, 2018 · Synced Sep 8, 2026, 2:32 PM EDT
Withdrawn No phase listed Observational

Study of Avelle™ Negative Pressure Wound Therapy (NPWT) System

NCT05805046
View directory record Official record
Conditions
Surgical Wound, Recent, Surgical Wound Leak, Dehiscence Wound, Trauma-related Wound
Interventions
Negative Pressure Wound Therapy System
Device
Lead sponsor
ConvaTec Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
4
States / cities
Miami Lakes, Florida • Chicago, Illinois • Lake Success, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2024 · Synced Sep 8, 2026, 2:32 PM EDT
Completed Not applicable Interventional Results available

Evaluating the Ease of Use of a VAC GranuFoam Bridge Dressing on Diabetic Foot Ulcers Receiving VAC Negative Pressure Wound Therapy

NCT00847730
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
V.A.C. Negative Pressure Wound Therapy System
Device
Lead sponsor
KCI USA, Inc
Industry
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
6
States / cities
New Haven, Connecticut • South Miami, Florida • Bethlehem, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Sep 8, 2026, 2:32 PM EDT
Withdrawn Not applicable Interventional

The Role of VAC Therapy Devices in Promoting Closure of Enterocutaneous Fistulae

NCT02519192
View directory record Official record
Conditions
Fistulae
Interventions
V.A.C.Ulta™ Negative Pressure Wound Therapy System, Vac sponge irrigations, ostomy bag, wet to dry dressings
Device · Procedure
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 2, 2018 · Synced Sep 8, 2026, 2:32 PM EDT
Completed Not applicable Interventional Results available

Vacuum-Assisted Dressings (V-AD) in the Management of Open Chest Wounds

NCT02803164
View directory record Official record
Conditions
Open Chest Wounds
Interventions
Wound Vacuum-assisted dressing, Control group
Device · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Sep 8, 2026, 2:32 PM EDT
Recruiting Phase 4 Interventional

Combined OFM and Vacuum-assisted Therapy for Expedited Regeneration Over Structures

NCT07385313
View directory record Official record
Conditions
Soft Tissue Defects, Soft Tissue Wounds, Traumatic Soft Tissue Defect
Interventions
Myriad™ applied in conjunction with NPWT, NPWT Alone
Device
Lead sponsor
Aroa Biosurgery Limited
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Aurora, Colorado • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 8, 2026, 2:32 PM EDT
Not listed Not applicable Interventional

Early Feasibility Study of a Novel Negative Pressure Wound Therapy Glove for Hand Injuries

NCT05844943
View directory record Official record
Conditions
Hand Injuries
Interventions
ReHeal glove with Negative Pressure Wound Therapy (NPWT)
Device
Lead sponsor
University of Washington
Other
Eligibility
22 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 25, 2024 · Synced Sep 8, 2026, 2:32 PM EDT
Not listed No phase listed Observational

Assess the Efficacy of Prevena Plus vs SOC to Closed Incision in Pts Undergoing CAWR and Other Laparotomy Procedures.

NCT04539015
View directory record Official record
Conditions
Hernia
Interventions
Prevena Plus
Device
Lead sponsor
New York Medical College
Other
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Sep 3, 2020 · Synced Sep 8, 2026, 2:32 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Do Single Use Negative Pressure Dressings Reduce Wound Complications in Obese Women After Cesarean Delivery

NCT02799667
View directory record Official record
Conditions
Obesity, Surgical Site Infections, Wound Complications, Complications; Cesarean Section
Interventions
Standard Dressing, Negative Pressure Wound Therapy Dressing
Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 20, 2021 · Synced Sep 8, 2026, 2:32 PM EDT
Completed Not applicable Interventional Results available

Study to Compare Negative Pressure Wound Therapy or Standard Dressings After Orthopedic Surgery

NCT02064270
View directory record Official record
Conditions
Wound of Knee, Wound of Hip
Interventions
Single-Use Negative Pressure Wound Therapy, Standard postsurgical dressings
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
526 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 16, 2018 · Synced Sep 8, 2026, 2:32 PM EDT
Terminated Not applicable Interventional Results available

Management of Complex Wounds Using a Constant Tension External Tissue Expander

NCT01171521
View directory record Official record
Conditions
Wounds and Injuries
Interventions
DermaClose Group
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 25, 2016 · Synced Sep 8, 2026, 2:32 PM EDT
Completed Not applicable Interventional Results available

Effect of Oasis® Wound Matrix on Stage III and IV Trunk Pressure Wounds Treated With Negative Pressure Wound Therapy

NCT02246608
View directory record Official record
Conditions
Open Wound Abdominal Wall, Wound Non Healing
Interventions
NPWT Standard of Care plus Oasis wound product, Routine NPWT Standard of Care
Device
Lead sponsor
Kettering Health Network
Other
Eligibility
18 Years to 89 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Kettering, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 26, 2018 · Synced Sep 8, 2026, 2:32 PM EDT
Withdrawn Phase 4 Interventional

RCT to Compare Restrata and NPWT to Heal Complex DFUs

NCT04405050
View directory record Official record
Conditions
Diabetic Wound
Interventions
Restrata, Negative Pressure Wound Therapy (NPWT)
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2023 · Synced Sep 8, 2026, 2:32 PM EDT
Not listed No phase listed Observational

Negative Pressure Wound Therapy Registry

NCT02467998
View directory record Official record
Conditions
Diabetic Foot Ulcers, Venous Stasis Ulcer, Pressure Ulcer, Surgical Wound Dehiscence, Burns, Other Types of Chronic Non Healing Wounds
Interventions
NPWT
Device
Lead sponsor
U.S. Wound Registry
Other
Eligibility
Not listed
Enrollment
50,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
1
States / cities
The Woodlands, Texas
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Sep 8, 2026, 2:32 PM EDT
Withdrawn Not applicable Interventional

Incisional Wound Vac in Obese Patients

NCT00789659
View directory record Official record
Conditions
Wound Infection, Postoperative Complication
Interventions
Negative pressure dressing
Other
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Feb 9, 2017 · Synced Sep 8, 2026, 2:32 PM EDT
Completed Phase 4 Interventional Results available

Use of Negative Pressure Wound Therapy in High Risk Surgical Closed Incisions

NCT02137447
View directory record Official record
Conditions
High Risk Abdominal Wounds
Interventions
Negative Pressure treatment
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 95 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Sep 8, 2026, 2:32 PM EDT
Withdrawn Not applicable Interventional

Negative Pressure Wound Therapy as a Drug Delivery System (ADANPWT)

NCT02308800
View directory record Official record
Conditions
Foot Ulcer, Diabetic
Interventions
Quantum™ Therapy - NPWT with Prontosan, Quantum™ Therapy
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years to 89 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 21, 2019 · Synced Sep 8, 2026, 2:32 PM EDT
Completed Not applicable Interventional Results available

Vacuum Assisted Closure as a Treatment for Soft Tissue Injuries

NCT00582998
View directory record Official record
Conditions
Fracture of Calcaneus, Pilon or Tibial Plateau
Interventions
Standard Wound Dressing, Vacuum Assisted Closure Device
Procedure · Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Sep 8, 2026, 2:32 PM EDT
Completed Not applicable Interventional

Vacuum Assisted Closure as a Treatment for Draining Hematomas

NCT00582179
View directory record Official record
Conditions
Draining Hematoma
Interventions
Standard Pressure Dressing, VAC
Procedure · Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 30, 2013 · Synced Sep 8, 2026, 2:32 PM EDT
Completed Phase 4 Interventional

Ethyl Chloride for NPWT

NCT04635696
View directory record Official record
Conditions
Pain, Acute
Interventions
Ethyl chloride, Tissue culture grade water
Drug · Other
Lead sponsor
ProMedica Health System
Other
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 11, 2021 · Synced Sep 8, 2026, 2:32 PM EDT
Recruiting Phase 3 Interventional

Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures

NCT06337292
View directory record Official record
Conditions
Fracture of Tibia, Wound Heal, Infected Wound, Wound Complication, Wound Dehiscence
Interventions
Incisional Negative Pressure Wound Therapy (NPWT)
Device
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years and older
Enrollment
352 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
6
States / cities
Baltimore, Maryland • Lebanon, New Hampshire • Nashville, Tennessee + 2 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 8, 2026, 2:32 PM EDT
Completed Not applicable Interventional Results available

Single-Use Negative Pressure Wound Therapy for Free Flap Donor Sites

NCT03340025
View directory record Official record
Conditions
Surgical Wound
Interventions
PICO Single Use Negative Pressure Wound Therapy System, xeroform gauze
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 29, 2021 · Synced Sep 8, 2026, 2:32 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effects of Post-Operative Interventions on Surgical Site Occurrences in AWR

NCT04906408
View directory record Official record
Conditions
Abdomen Hernia
Interventions
Prevena, Prineo, Traditional
Device · Drug
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Sep 8, 2026, 2:32 PM EDT