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These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 21, 2026, 9:12 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–11 of 11 matching trials from the live ClinicalTrials.gov search.

Conditions: Seasonal Affective Disorder
Interventions: Negative Ion Generator, Light-emitting Photodiode light treatment device; Device
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 106 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 3
States / cities: New Haven, Connecticut • Rockville, Maryland • Belmont, Massachusetts

Conditions: Anxiety, Depression, Sleep
Interventions: Litebook Bright Light Box, Litebook inactivated negation ion generator (the placebo); Device
Lead sponsor: University of South Carolina; Other
Eligibility: 18 Years to 35 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Columbia, South Carolina

Conditions: Seasonal Affective Disorder, Mood Disorders, Depression
Interventions: bright light box, dawn simulator, high-output negative ion generator, low-output negative ion generator, dawn light pulse; Device
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 70 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1998 – 2004
U.S. locations: 1
States / cities: New York, New York

Conditions: Traumatic Brain Injury, Post-traumatic Stress Disorder, Chronic Pain
Interventions: Morning Bright Light Therapy, Negative Ion Generator; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 89 Years
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Mood Disorders, Depressive Disorders, Depression, Chronic Depression
Interventions: Bright light box, High-output negative ion generator, Low-output negative ion generator; Device
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 65 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2004
U.S. locations: 2
States / cities: Middletown, Connecticut • New York, New York

Conditions: Sleep, Phototherapy, Glymphatic System, Mitochondrial Dynamics, Brain Injuries, Traumatic, Inflammation
Interventions: Morning Bright Light Therapy, Negative Ion Generator Therapy; Device
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years to 89 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Seasonal Affective Disorder
Interventions: Litebook treatment devices, Inactivated negative ion generator; Device
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2005
U.S. locations: 1
States / cities: New Haven, Connecticut

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