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Showing 1–24 of 222 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Neuroimaging Investigation Clear all
Terminated Early Phase 1 Interventional Accepts healthy volunteers

Open-label Study to Evaluate Brain α-Synuclein Deposition Using PET and [18F]MK-0947 in Parkinson's Disease

NCT07348250
View directory record Official record
Conditions
Parkinson's Disease (PD), Parkinson's Disease, Parkinson's Disease (Disorder)
Interventions
[18F]MK-0947
Drug
Lead sponsor
Invicro
Other
Eligibility
18 Years to 80 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 2, 2026, 6:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Brain on Whole Body Hyperthermia: A Neuroimaging Study

NCT02062840
View directory record Official record
Conditions
Major Depression
Interventions
High intensity whole-body infrared heating, Low intensity whole-body infrared heating, Functional Magnetic Resonance Imaging (fMRI) and electrocardiogram (EKG), Questionnaires
Device · Other
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 30 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 9, 2015 · Synced Sep 2, 2026, 6:33 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neural Mechanisms of Cost and Benefit Integration During Decision-Making, Aim 2: Acute & Lifetime Stress

NCT04060966
View directory record Official record
Conditions
Healthy
Interventions
Cold-Pressor Task (CPT), Control CPT, fMRI
Behavioral · Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 64 Years
Enrollment
397 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Sep 2, 2026, 6:33 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pediatric Type 1 Diabetes and Neurocognitive Complications Cohort Study

NCT04135365
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
neurocognitive assessment, neuroimaging assessment
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
6 Years to 11 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 31, 2022 · Synced Sep 2, 2026, 6:33 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Brain Imaging and Pain: Analysis of Placebo Analgesia

NCT01409538
View directory record Official record
Conditions
Brain Imaging of Placebo Analgesia
Interventions
Placebo Instructions, Control condition
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 19, 2015 · Synced Sep 2, 2026, 6:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Surgical Theater's Surgery Rehearsal Platform

NCT02099318
View directory record Official record
Conditions
Cerebral Aneurysm Unruptured, Cerebral Aneurysm Ruptured
Interventions
Active SRP cases, Control cases
Other
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 4, 2017 · Synced Sep 2, 2026, 6:33 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Childhood Outcomes of Preterm Brain Abnormalities

NCT03410810
View directory record Official record
Conditions
Premature Birth, Neurodevelopmental Disorders, Brain Development Abnormality, Brain Lesion
Interventions
MRI, Neurodevelopmental/Neuropsychological Assessment
Diagnostic Test
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
Up to 8 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 9, 2024 · Synced Sep 2, 2026, 6:33 AM EDT
Completed Not applicable Interventional

Hyperfine Portable MRI in Hydrocephalus and Other Conditions Prompting Outpatient Brain Imaging

NCT04436068
View directory record Official record
Conditions
Hydrocephalus, Neurological Disorder
Interventions
Hyperfine MRI scan
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 2, 2026, 6:33 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

HCV and Co-morbid Alcohol Use Disorders: A Translational Investigation of Antiviral Therapy Outcomes on CNS Function

NCT03902366
View directory record Official record
Conditions
Hepatitis C, Alcohol Use Disorder
Interventions
Neuropsychological assessment, Neuroimaging
Diagnostic Test · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years and older
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Sep 2, 2026, 6:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessment of tDCS-Induced Neuronal Responses in Multiple Sclerosis (MS) With Advanced MRI

NCT03564496
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
tDCS Administration during MRI, Remotely-supervised Daily tDCS Administration, Optional 15 minutes of imaging + simultaneous tDCS up to 4.0mA
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 79 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 16, 2024 · Synced Sep 2, 2026, 6:33 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

A Study of How Proton Beam Radiotherapy (PBRT) Affects Brain Function and Quality of Life in Children and Young Adults Undergoing Treatment for a Brain Tumor

NCT05288439
View directory record Official record
Conditions
Brain Tumor, Metastatic Brain Tumor
Interventions
Resting-state functional connectivity MRI, Neurocognitive battery with quality-of-life assessment
Diagnostic Test · Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
6 Years to 25 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 22, 2026 · Synced Sep 2, 2026, 6:33 AM EDT
Active, not recruiting No phase listed Observational

ROSE-Longitudinal Assessment With Neuroimaging

NCT05089331
View directory record Official record
Conditions
Intracerebral Hemorrhage
Interventions
Not listed
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
7
States / cities
Chicago, Illinois • Louisville, Kentucky • Baltimore, Maryland + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 2, 2026, 6:33 AM EDT
Completed No phase listed Observational

Brain Imaging Changes Following Proton Therapy for Pediatric Primary Central Nervous System and Base of Skull Tumors

NCT04296617
View directory record Official record
Conditions
Malignant Central Nervous System Neoplasm, Malignant Skull Base Neoplasm
Interventions
Medical Chart Review
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
Up to 21 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Sep 2, 2026, 6:33 AM EDT
Completed Phase 2 Interventional

MCLENA-1: A Clinical Trial for the Assessment of Lenalidomide in Amnestic MCI Patients

NCT04032626
View directory record Official record
Conditions
Cognitive Impairment, Mild, Cognitive Dysfunction, Amyloid Plaque, Neurodegeneration, Inflammation, Brain
Interventions
Lenalidomide 10 mg, Placebo
Drug
Lead sponsor
St. Joseph's Hospital and Medical Center, Phoenix
Other
Eligibility
50 Years to 89 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
2
States / cities
Phoenix, Arizona • Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 2, 2026, 6:33 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Evaluation of a Novel Positron Emission Tomography (PET Radiotracer for TARP Gamma-8

NCT02108015
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Brain Imaging (PET), Aterial Line, Blood Sampling
Procedure
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 55 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 19, 2019 · Synced Sep 2, 2026, 6:33 AM EDT
Recruiting No phase listed Observational

Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates

NCT07275021
View directory record Official record
Conditions
Preterm Less Than 32wks With IVH, WMI/PVL, Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE
Interventions
Prospective Clinical and Neurodevelopmental Data Collection
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
31 Weeks to 42 Weeks
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Sep 2, 2026, 6:33 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Characterization Imaging Instruments in Alcoholics and Non-Alcoholics

NCT02108080
View directory record Official record
Conditions
Alcohol Dependence, Alcohol Drinking, Alcohol-Related Disorders, Alcoholism, Brain Mapping
Interventions
Not listed
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 2, 2026, 6:33 AM EDT
Completed Early Phase 1 Interventional

Predicting Treatment Response to Memantine in Autism Using Magnetic Resonance Spectroscopy

NCT02811627
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
Memantine, Magnetic Resonance Imaging
Drug · Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
16 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 13, 2021 · Synced Sep 2, 2026, 6:33 AM EDT
Completed No phase listed Observational

Evaluation, Pathogenesis, and Outcome of Subjects With or Suspected Traumatic Brain Injury

NCT01132937
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
886 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 2, 2026, 6:33 AM EDT
Active, not recruiting No phase listed Observational

A Study of Memory, Thinking, and Brain Imaging in Adults With Histiocytosis

NCT03127709
View directory record Official record
Conditions
Histiocytosis
Interventions
Trail Making Test, Parts A & B, Brief Test of Attention, Symbol Span, Controlled Oral Word Association Test, The Hopkins Verbal Learning Test-Revised, Brief Visuospatial Memory Test-Revised, Hospital Anxiety and Depression Scale, McGill Quality of Life Scale, MR Brain Imaging, Resting state functional MRI, Functional Assessment of Cancer Therapy Cognitive Scale (FACT-Cog)
Behavioral · Diagnostic Test
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
4
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Commack, New York + 1 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 2, 2026, 6:33 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Cognitive Decline Following Deep Brain Stimulation

NCT05822388
View directory record Official record
Conditions
Parkinson Disease, Movement Disorders
Interventions
Deep Brain Stimulation Surgical Procedures as Part of Routine Clinical Care
Procedure
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 2, 2026, 6:33 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Examining Cognitive Function and Brain Abnormalities in Adults With Sickle Cell Disease

NCT00528801
View directory record Official record
Conditions
Anemia, Sickle Cell
Interventions
NP Battery, MRI
Behavioral · Procedure
Lead sponsor
UCSF Benioff Children's Hospital Oakland
Other
Eligibility
21 Years to 55 Years
Enrollment
212 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
12
States / cities
Los Angeles, California • Oakland, California • Hollywood, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2017 · Synced Sep 2, 2026, 6:33 AM EDT
Completed Not applicable Interventional

Neurocognitive and Neuroimaging Outcomes in Older Patients With Multiple Myeloma Treated With Autologous Stem Cell Transplantation

NCT03508765
View directory record Official record
Conditions
Multiple Myeloma
Interventions
Structural Image, Functional Image, Digit Span subtest, Brief Test of Attention, Trail Making Test (Parts A & B), Auditory Consonant Trigrams Test, Controlled Oral Word Association Test, Hopkins Verbal Learning Test-Revised, The Center for Epidemiological Study-Depression, The Functional Assessment of Chronic Illness Therapy-Fatigue Subscale, Version 4, Blood draw
Diagnostic Test · Behavioral · Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
60 Years to 75 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
2
States / cities
New Brunswick, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Sep 2, 2026, 6:33 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Brain Functional Connectivity in Alcohol Use Disorder

NCT02877849
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
MRI: Brain Imaging data collection
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 60 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 5, 2019 · Synced Sep 2, 2026, 6:33 AM EDT