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Conditions: Brain Blood Flow, Neurovascular Control
Interventions: MRI, Transcranial Doppler Ultrasound, Sympathetic Nerve Activity; Device · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 45 Years to 68 Years
Enrollment: 70 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Craniosynostoses
Interventions: MRI,DTI, functional MRI; Diagnostic Test
Lead sponsor: University of Arkansas; Other
Eligibility: Up to 4 Years
Enrollment: 9 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Traumatic Brain Injury, Veterans
Interventions: Not listed
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 55 Years
Enrollment: 100 participants
Timeline: 2007 – 2016
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Hyponatremia Symptomatic, Osmotic Demyelination Syndrome, Cerebral Edema
Interventions: Hypertonic 3% saline; Drug
Lead sponsor: Rochester General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Metastatic Cancer
Interventions: questionnaire administration, diffusion tensor imaging, functional magnetic resonance imaging, hypo-fractionated SRS, single-fraction SRS; Other · Procedure · Radiation
Lead sponsor: Boston Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2017
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Succinic Semialdehyde Dehydrogenase Deficiency
Interventions: Transcranial magnetic stimulation (TMS), Magnetic resonance imaging (MRI), Electroencephalogram (EEG), Bio-specimen Collection; Device · Procedure
Lead sponsor: Boston Children's Hospital; Other
Eligibility: Not listed
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: B-Cell Non-Hodgkin Lymphoma
Interventions: Anakinra, X-Ray Imaging, Positron Emission Tomography, Computed Tomography, Bone Marrow Aspiration, Bone Marrow Biopsy, Lumbar Puncture, Biospecimen Collection; Biological · Procedure
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Mild Cognitive Impairment, Alzheimer's Disease
Interventions: Lumbar puncture, Blood draw, Magnetic Resonance Imaging (MRI); Procedure
Lead sponsor: Emory University; Other
Eligibility: 60 Years to 85 Years
Enrollment: 135 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Healthy Aging
Interventions: Continuous theta burst transcranial magnetic stimulation; Device
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years to 80 Years
Enrollment: 248 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Speech
Interventions: MEG/EEG, MRI, Speaking Tasks; Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 2
States / cities: Madison, Wisconsin • Milwaukee, Wisconsin

Conditions: Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Leptomeninges, Stage IV Lung Cancer AJCC v8
Interventions: Biospecimen Collection, Computed Tomography, Involved-Field Radiation Therapy, Lumbar Puncture, Magnetic Resonance Imaging, Positron Emission Tomography, Proton Beam Craniospinal Irradiation, Quality-of-Life Assessment; Procedure · Radiation · Other
Lead sponsor: NRG Oncology; Other
Eligibility: 18 Years and older
Enrollment: 115 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2033
U.S. locations: 58
States / cities: Phoenix, Arizona • Little Rock, Arkansas • Encinitas, California + 45 more

Conditions: Recurrent Mantle Cell Lymphoma, Refractory Mantle Cell Lymphoma
Interventions: Biopsy, Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy, Computed Tomography, Lenalidomide, Lumbar Puncture, Magnetic Resonance Imaging, Positron Emission Tomography, Tafasitamab, Venetoclax; Procedure · Drug · Biological
Lead sponsor: Academic and Community Cancer Research United; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2030
U.S. locations: 2
States / cities: Rochester, Minnesota • Houston, Texas

Conditions: Cognitive Flexibility, Emotional Regulation
Interventions: Healthy Minds Program, Sham Meditation Didactic Material, Sham Stimulation in Lab, Stimulation in Lab, MRI Scanner; Other · Device
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 50 Years
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Glioblastoma (GBM), Diffuse Midline Glioma (DMG), Astrocytoma, IDH-Mutant, Grade 4, Diffuse Hemispheric Glioma, H3 G34-Mutant, Gliosarcoma of Brain
Interventions: Nivolumab, Azacitidine (AZA), lumbar puncture, MRI Contrast; Drug · Procedure · Diagnostic Test
Lead sponsor: Andrew P. Groves; Other
Eligibility: 13 Years and older
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Obsessive-Compulsive Disorder, Pain, Intractable, Depression
Interventions: fMRI and DTI, Behavioral questionnaires, Disease-Specific Patient-Reported Outcomes, Behavioral tests; Diagnostic Test · Behavioral
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Cognitive/Functional Effects, Colorectal Cancer, Long-term Effects Secondary to Cancer Therapy in Adults
Interventions: cognitive assessment, magnetic resonance imaging, management of therapy complications; Procedure
Lead sponsor: University of Arizona; Other
Eligibility: Not listed
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2006
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Stage I Endometrial Adenocarcinoma, Uterine Cancer, Obesity
Interventions: Exercise on stationary recumbent exercise cycle, Health Education, Questionnaires, Neuroimaging, Genetic and Biomarkers; Behavioral · Procedure
Lead sponsor: Case Comprehensive Cancer Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2019
U.S. locations: 2
States / cities: Cleveland, Ohio

Conditions: Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cancer
Interventions: Neuroimaging & Neuropsychological Evaluation; Other
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 21 Years to 70 Years · Female only
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2022
U.S. locations: 1
States / cities: New York, New York

Conditions: Healthy, Aging
Interventions: MRI, TCD; Device
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 20 Years to 64 Years
Enrollment: 46 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Mammoplasty Patient
Interventions: Angiography, MRI-Based Angiogram, Quality-of-Life Assessment; Procedure · Other
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Cerebral Palsy, Chronic Pain
Interventions: MRI; Diagnostic Test
Lead sponsor: Hugo W. Moser Research Institute at Kennedy Krieger, Inc.; Other
Eligibility: 8 Years and older
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2028
U.S. locations: 4
States / cities: Baltimore, Maryland

Conditions: Spinal Cord Injuries
Interventions: Acute Intermittent Hypoxia; Other
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 43 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Brain Trauma
Interventions: Conventional MRI of the brain, MR spectroscopy (MRS), MR Diffusion Tensor Imaging (DTI); Other
Lead sponsor: University of Michigan; Other
Eligibility: Not listed
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2009
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Mild Traumatic Brain Injury, Traumatic Brain Injury
Interventions: MRI; Device
Lead sponsor: GE Healthcare; Industry
Eligibility: 15 Years to 50 Years
Enrollment: 112 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: New York, New York

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Cardiovascular and Neurovascular Regulation in GWI

Neurodevelopmental Outcomes in Craniosynostosis Repair

Awareness of Deficit After Combat-related Brain Injury

International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia

Stereotactic Radiosurgery in Treating Patients With Spinal Metastases

Natural History Study of Patients With Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency

Anakinra for the Prevention of Cytokine Release Syndrome and Neurotoxicity in Patients With B-Cell Non-Hodgkin Lymphoma Receiving CD19-Targeted CAR-T Cell Therapy

African American Alzheimer's Progression Markers - CSF and Neuro-Imaging

Evaluating the Neurocomputational Mechanisms of Explore-Exploit Decision Making in Older Adults

Behavioral and Neural Responses to External Alterations of Speech Variability

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

Tafasitamab, Lenalidomide and Venetoclax for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

The STRENGTHEN Study

Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade Glioma

Psychosocial, Behavioral, and Radiologic Changes Following Radiosurgery for Benign Neurologic Disease

Neurological Effects of Chemotherapy and Radiation Therapy in Patients With Colon Cancer

Assisted Exercise in Obese Endometrial Cancer Patients

Structural and Functional Imaging and Cognitive Functions in Ovarian Cancer

Brain Blood Flow: Age and Gender

Evaluation of Perforator Phase Contrast Angiography in Developing Surgery Plans for Patients With Breast Cancer Undergoing Breast Reconstruction With Free-Flap Methods After Mastectomy

Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy

Measuring the Neurological Benefits of Intermittent Hypoxia Therapy With MRI

Magnetic Resonance (MR) Spectroscopy and Diffusion Tensor Imaging in Determining Brain Injury and Subsequent Clinical Outcome in Patients of Moderate Brain Trauma

Advanced MRI Applications for Mild Traumatic Brain Injury