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ClinicalTrials.gov public records Last synced Oct 21, 2026, 1:29 AM EDT

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Showing 1–24 of 39 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Nicotine Pouches Clear all
Enrolling by invitation Phase 4 Interventional

Piloting Novel Interventional Strategies to Improve Nicotine Pouches as a Substitute for Smoking

NCT07625956
View directory record Official record
Conditions
Smoking ( Cigarette)
Interventions
Nicotine replacement therapy patches, Oral nicotine pouches
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 21, 2026, 1:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Characterize Nicotine Pharmacokinetics and Subjective Effects of Nicotine Pouches in Adult Cigarette Smokers

NCT04846088
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking
Interventions
Product A, Product B, Product C, Product D, Product E, Product F, Product G, Product H, Product I
Other
Lead sponsor
British American Tobacco (Investments) Limited
Industry
Eligibility
22 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Dec 7, 2022 · Synced Oct 21, 2026, 1:29 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches

NCT07165808
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Nicotine pouch: Low dose, Nicotine pouch: High dose, Low pH, High pH
Other
Lead sponsor
Emory University
Other
Eligibility
21 Years to 35 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 21, 2026, 1:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD231005 Nicotine Pouch Biomarkers of Exposure

NCT06303115
View directory record Official record
Conditions
Tobacco Use, Smoking
Interventions
Nicotine Pouch P1312914, 4 mg nicotine, Nicotine Pouch P1312915, 8 mg nicotine, Nicotine Pouch P1013215, 8 mg nicotine, Nicotine Pouch P1013218, 10 mg nicotine, Nicotine Pouch P1012919, 12 mg nicotine, Smoking Abstinence, Continued UB cigarette smoking
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
5
States / cities
Bentonville, Arkansas • Lexington, Kentucky • Springfield, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 11, 2025 · Synced Oct 21, 2026, 1:29 AM EDT
Recruiting Phase 4 Interventional

The Options 2 Study

NCT06595459
View directory record Official record
Conditions
Smoker, Smoking Cessation
Interventions
Nicotine Pouches, Mini Nicotine lozenges
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
21 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 21, 2026, 1:29 AM EDT
Not yet recruiting Phase 1 Interventional Accepts healthy volunteers

Understanding Oral Nicotine Pouch Use in Healthy Volunteers

NCT07829939
View directory record Official record
Conditions
Healthy Adult Participants
Interventions
0 mg oral nicotine pouches, 3 mg oral nicotine pouches, 6 mg oral nicotine pouches, cigarette or e-cigarette
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 21, 2026, 1:29 AM EDT
Not listed Not applicable Interventional

Using ANDS to Reduce Harm for Low SES Cigarette Smokers

NCT05327439
View directory record Official record
Conditions
Smoking, Cigarette, Nicotine Dependence
Interventions
Nicotine (electronic cigarette), Nicotine (nicotine pouch)
Other
Lead sponsor
Brown University
Other
Eligibility
21 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 26, 2023 · Synced Oct 21, 2026, 1:29 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Oral Nicotine and Caffeine Pouches on Anaerobic Performance, Autonomic Function, Cognition, and Behavior

NCT06529055
View directory record Official record
Conditions
Fatigue; Muscle, Heart, Fatigue, Mental
Interventions
Oral Pouch - Nicotine, Oral Pouch - Caffeine, Oral Pouch - Placebo
Other
Lead sponsor
University of Southern Mississippi
Other
Eligibility
21 Years to 40 Years · Male only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Hattiesburg, Mississippi
Source: ClinicalTrials.gov public record
Updated Aug 2, 2024 · Synced Oct 21, 2026, 1:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD201001: Study to Assess Elements of Abuse Liability for Three Nicotine Pouches

NCT05129657
View directory record Official record
Conditions
Smoking, Tobacco Use, Tobacco Smoking
Interventions
Product A, Product B, Product C, Product D, Product N
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Raleigh, North Carolina • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Oct 21, 2026, 1:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD190401: A Study to Assess Elements of Abuse Liability for Nicotine-containing Pouch Tobacco Products

NCT04372290
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Interventions
Product A, Product B, Product C, Product D, Product E
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 25, 2020 · Synced Oct 21, 2026, 1:29 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Studying Flavors and Cooling Agents in Oral Nicotine Pouches to Understand User Preferences

NCT07111234
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Carbon Monoxide Measurement, Nicotine Oral Pouch, Questionnaire Administration, Smoke usual brand cigarette
Procedure · Drug · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 21, 2026, 1:29 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

THRIVE Study: Understanding How Oral Nicotine Pouches Affect Public Health

NCT07503925
View directory record Official record
Conditions
Tobacco-Related Carcinoma
Interventions
Biospecimen Collection, Nicotine Oral Pouch, Survey Administration, Text Message-Based Navigation Intervention
Procedure · Drug · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 21, 2026, 1:29 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

CSD201004: An Actual Use Study of P10 and P13 Nicotine Pouches Among U.S. Adult Smokers

NCT05184920
View directory record Official record
Conditions
Smoking, Tobacco Use, Tobacco Smoking
Interventions
P1012919 nicotine pouch, P1012915 nicotine pouch, P1012914 nicotine pouch, P1013315 nicotine pouch, P1013119 nicotine pouch, P1013218 nicotine pouch, P1012818 nicotine pouch, P1312915 nicotine pouch, P1312914 nicotine pouch, P1313015 nicotine pouch, P1313314 nicotine pouch, P1312815 nicotine pouch
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
1,105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
10
States / cities
Phoenix, Arizona • Atlanta, Georgia • Chicago, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Oct 21, 2026, 1:29 AM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

Nicotine Pouch Pharmacokinetics Abuse Liability

NCT07476144
View directory record Official record
Conditions
Smoking Behaviors
Interventions
Participants will place the pouch between their top lip and their gum for 30 minutes as per use instructions.
Drug
Lead sponsor
JT International SA
Industry
Eligibility
22 Years to 65 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
2
States / cities
Knoxville, Tennessee • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 21, 2026, 1:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Assess the Pharmacokinetics of Oral Nicotine Pouches and Lozenges in Healthy Adults

NCT04755348
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Cigarette Smoking
Interventions
Product A, Product B, Product C, Product D, Product E, Product F
Other
Lead sponsor
British American Tobacco (Investments) Limited
Industry
Eligibility
21 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 30, 2021 · Synced Oct 21, 2026, 1:29 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

NCT06372899
View directory record Official record
Conditions
E-cigarette Use, Cigarette Smoking, Harm Reduction, Tobacco Use
Interventions
E-cigarettes, Oral nicotine pouches
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
21 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Oct 21, 2026, 1:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD201002: Study to Assess Nicotine Uptake From P10 Nicotine Pouches

NCT05081154
View directory record Official record
Conditions
Smoking, Tobacco Use
Interventions
Product A, Product B, Product C, Product D, Product E, Product F, Product G
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Oct 21, 2026, 1:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Oral Nicotine Pouch Marketing Features Influence on Perceptions

NCT06605924
View directory record Official record
Conditions
Tobacco Use
Interventions
Tobacco-free, Discrete, Convenient
Other
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
13 Years to 120 Years
Enrollment
5,133 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 21, 2026, 1:29 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Abuse Liability and Appeal of Oral Nicotine Products

NCT06506162
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Flavor, Nicotine concentration
Other
Lead sponsor
University of Southern California
Other
Eligibility
21 Years to 25 Years
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 21, 2026, 1:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches

NCT05294497
View directory record Official record
Conditions
Smoking, Tobacco Use, Tobacco Smoking
Interventions
Product A, Product B, Product C, Product D, Product N, Product E
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
2
States / cities
Lexington, Kentucky • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 29, 2022 · Synced Oct 21, 2026, 1:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of E-Liquid Flavor on Respiratory Symptoms in People Using Electronic Nicotine Delivery Systems

NCT05423340
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
E-cigarette Flavor, Tobacco Free Nicotine Pouch
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 21, 2026, 1:29 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use

NCT07698470
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Oral Nicotine Pouch, Smoking Cue Reactivity Task
Other · Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
21 Years to 55 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 21, 2026, 1:29 AM EDT
Completed Not applicable Interventional Results available

Switching to Potential Reduced Exposure Products in Adult Smokers

NCT04250727
View directory record Official record
Conditions
Tobacco Use Disorder, Oral Nicotine Pouch Use, Smoking Behaviors, Harm Reduction, Toxic Effect of Tobacco and Nicotine, Carcinogenesis
Interventions
ZYN
Device
Lead sponsor
Yale University
Other
Eligibility
21 Years to 77 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 1, 2024 · Synced Oct 21, 2026, 1:29 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Flavored on!® Nicotine Pouch Products on Smoking Behaviors: a SMART Study

NCT06072547
View directory record Official record
Conditions
Cigarette Smoking Behavior
Interventions
Access to all varieties of on! 4mg nicotine pouches (Berry, Citrus, Cinnamon, Wintergreen, Mint, Coffee, and Original), Access to Original on! 4mg nicotine pouches, Non-Flavored then complete flavor on! nicotine pouches
Other
Lead sponsor
Altria Client Services LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 11, 2024 · Synced Oct 21, 2026, 1:29 AM EDT