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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Nicotine Research Cigarette Clear all
Recruiting Phase 1 Interventional Accepts healthy volunteers

Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

NCT05962229
View directory record Official record
Conditions
Nicotine Dependence, Nicotine Vaping
Interventions
(S)-Nicotine, (R)- nicotine, Racemic nicotine
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cigarette Smoking in Smokers With and Without Schizophrenia

NCT04001114
View directory record Official record
Conditions
Tobacco Dependence, Schizophrenia
Interventions
Sampling Research Cigarettes
Combination Product
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 60 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 25, 2024 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Not applicable Interventional

Project 1, Study 2: The Combined Impact of Nicotine Replacement and Spectrum Cigarettes

NCT02301325
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Smoking research cigarettes with or without NRT
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Sep 29, 2026, 1:26 AM EDT
Active, not recruiting Not applicable Interventional

Smoking Cessation Intervention for Cancer Patients

NCT00575718
View directory record Official record
Conditions
Newly Diagnosed Cancer Patients
Interventions
Hospital Counseling + Nicotine Replacement Therapy. questionaires, Hospital Counseling + Nicotine Replacement + Presurgical Scheduled Reduced Smoking, questionaires
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Switching to Reduced Oxidant or Nicotine Content Cigarettes in Smokers

NCT02415270
View directory record Official record
Conditions
Tobacco Smoking Behavior
Interventions
Reduced Nicotine Cigarettes, Reduced ROS/RNS, Control
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 26, 2018 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Neuroimaging Reward, Behavioral Treatment, and Smoking Cessation

NCT02927847
View directory record Official record
Conditions
Smoking
Interventions
Nicotine Patch, SPECTRUM Nicotine Research Cigarettes (.03 mg), Behavioral Activation, Supportive Counseling
Drug · Behavioral
Lead sponsor
Maggie M Sweitzer, PhD
Other
Eligibility
18 Years to 55 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers

NCT05271578
View directory record Official record
Conditions
Vascular Reactivity, Serum Biomarkers
Interventions
Standardized Electronic Research Cigarette, Nicotine Research Cigarette
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 45 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Low Nicotine Cigarettes Plus Electronic Cigarettes

NCT04058717
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Normal Nicotine Content research cigarettes, High Nicotine e-cigarette, Very Low Nicotine Content research cigarettes, Zero Nicotine e-cigarette
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Not applicable Interventional

C-FLASH (Cigarillo Flavor and Abuse Liability, Attention, and Substitution in youtH)

NCT04358705
View directory record Official record
Conditions
Smoking Behaviors
Interventions
Aim 1: Online survey, Eye Tracking Activity, Eye tracking survey, Online Experimental Marketplace (ETM), Aim 3 survey, Cognitive Interviews, Supplemental Aim 1 Interviews
Other · Behavioral
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
16 Years to 28 Years
Enrollment
658 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 5, 2024 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Not applicable Interventional

Project HEALS (Helping and Empowering pAtients for Living a Life Smoke-free

NCT05362318
View directory record Official record
Conditions
Smoking, Tobacco Use, Lung Cancer
Interventions
Nicotine patch and lozenges, Telephone counseling sessions, Access to a web-based video, Florida Tobacco Quitline
Drug · Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Smoking and Ventricular Repolarization

NCT03916341
View directory record Official record
Conditions
Sudden Cardiac Death, Prolonged QTc Interval
Interventions
EC with nicotine, EC without nicotine, control, TC with nicotine (own brand), research TC with very low level nicotine
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 45 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 3, 2023 · Synced Sep 29, 2026, 1:26 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes

NCT06614504
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Varying the nicotine content of cigarettes, Varying the nicotine content of e-cigarettes
Other
Lead sponsor
University of Vermont
Other
Eligibility
21 Years and older
Enrollment
308 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
2
States / cities
Providence, Rhode Island • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jun 26, 2025 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder

NCT02990455
View directory record Official record
Conditions
Alcohol Drinking, Cigarette Smoking Toxicity
Interventions
Reduced nicotine cigarettes
Drug
Lead sponsor
Battelle Memorial Institute
Other
Eligibility
21 Years to 65 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Nicotine, Non-Smokers With and Without ADHD, and Genetics Study

NCT01819259
View directory record Official record
Conditions
Non-smoker, ADHD
Interventions
Nicotine nasal spray, Placebo
Drug
Lead sponsor
Scott Kollins, PhD
Other
Eligibility
18 Years to 25 Years
Enrollment
136 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 29, 2018 · Synced Sep 29, 2026, 1:26 AM EDT
Recruiting Phase 2 Interventional

E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder

NCT05722561
View directory record Official record
Conditions
Opioid Use Disorder, Cigarette Smoking
Interventions
Telehealth Motivational Counseling, Nicotine Replacement Product, National Institute on Drug Abuse (NIDA) Standardized Research Electronic Cigarette (SREC).
Behavioral · Drug · Device
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 75 Years
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking

NCT03311646
View directory record Official record
Conditions
Smoking
Interventions
Normal nicotine content cigarettes (NNC, Baseline), Very low nicotine content (VLNC)
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 27, 2020 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs

NCT03691350
View directory record Official record
Conditions
Cigarette Smoker, Current Every Day Smoker
Interventions
Bronchoscopy with Bronchoalveolar Lavage, Cigarette, Electronic Cigarette, Laboratory Biomarker Analysis, Nicotine Replacement, Questionnaire Administration
Procedure · Drug · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 52 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Phase 4 Interventional Results available

A Text Messaging Program for Smokers in Primary Care

NCT03174158
View directory record Official record
Conditions
Smoking Cessation
Interventions
Mailed nicotine replacement therapy, Text messaging, Brief advice
Drug · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 6, 2020 · Synced Sep 29, 2026, 1:26 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Screening Protocol for Research Participants

NCT01010620
View directory record Official record
Conditions
Schizophrenia, Substance Abuse, Cocaine Abuse, Tobacco Use Disorder
Interventions
Various Screening psychiatric and medical assessments
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 64 Years
Enrollment
523 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2019
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 18, 2019 · Synced Sep 29, 2026, 1:26 AM EDT
Recruiting Not applicable Interventional

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

NCT06077240
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Nicotine Dependence
Interventions
E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 5% Nicotine with Tobacco Flavor Only, Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 3mg Nicotine with Tobacco Flavor Only, Tobacco Pouches with 6mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 6mg Nicotine with Tobacco Flavor Only
Behavioral
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Facilitating Smoking Cessation With Reduced Nicotine Cigarettes

NCT02796391
View directory record Official record
Conditions
Smoking Cessation
Interventions
Very Low Nicotine Content (VLNC) Cigarettes, One on One Counseling
Drug · Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 13, 2022 · Synced Sep 29, 2026, 1:26 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Cigarette Harm Reduction With Electronic Cigarette Use

NCT03473483
View directory record Official record
Conditions
Nicotine Dependence, Tobacco Toxicity, Nicotine Dependence, Cigarettes, Cardiovascular Risk Factor, Nicotine Withdrawal
Interventions
SREC
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 8, 2022 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Predictors and Consequences of Combustible Cigarette Smokers' Switch to Standardized Research E-Cigarettes

NCT03277495
View directory record Official record
Conditions
Tobacco Use
Interventions
Brief behavioral counseling
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
21 Years and older
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 29, 2026, 1:26 AM EDT
Completed Not applicable Interventional

Novel Approaches to Reducing Tobacco Related Harm

NCT02600273
View directory record Official record
Conditions
Smoking, Tobacco Smoking Behavior, Cigarette Smoking
Interventions
Usual brand cigarettes, Lower nicotine content cigarettes, Electronic cigarettes 1, Electronic cigarettes 2
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 29, 2020 · Synced Sep 29, 2026, 1:26 AM EDT