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ClinicalTrials.gov public records Last synced Nov 15, 2026, 3:00 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 337–360 of 429 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Nicotine replacement Clear all

Conditions: Second Hand Tobacco Smoke, Nicotine Dependence
Interventions: Clinic Quality Improvement + Behavioral Counseling, Clinic Quality Improvement + Attention Control; Behavioral
Lead sponsor: Temple University; Other
Eligibility: 18 Years and older
Enrollment: 327 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 4
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking
Interventions: Post-discharge automated phone calls (IVR) with option to connect with a tobacco coach., Nicotine Replacement Therapy, Varenicline, Metabolism Informed Smoking Treatment (Nicotine metabolite ratio (NMR)-based selection of pharmacotherapy); Behavioral · Drug · Other
Lead sponsor: Vanderbilt-Ingram Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 606 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Environmental Tobacco Smoke, Smoking Cessation
Interventions: nicotine replacement therapy (NRT), motivational advice, Quitline referral; Drug · Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: Not listed
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking Cessation
Interventions: Standard Care, Precision pharmacotherapy; Behavioral
Lead sponsor: Christiana Care Health Services; Other
Eligibility: 18 Years and older
Enrollment: 37 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: Newark, Delaware

Conditions: Nicotine Addiction, Panic Attack
Interventions: d-cycloserine, Pill Placebo, Nicotine replacement therapy, Panic and Smoking Reduction Treatment; Drug · Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years to 65 Years
Enrollment: 53 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Nicotine Dependence
Interventions: Nicotine Patches, Denicotinized Cigarettes; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 257 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation
Interventions: Smart-T + NRT, QuitGuide + NRT; Combination Product
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years and older
Enrollment: 454 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Cigarette Smoking
Interventions: Best Practices, Financial Incentives, Nicotine Replacement Therapy; Behavioral · Drug
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older · Female only
Enrollment: 198 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Smoking Cessation
Interventions: Spotlight on Smoke-Free Living: Mindsets and Decisions, Transdermal Nicotine Patch; Behavioral · Drug
Lead sponsor: University of Florida; Other
Eligibility: 18 Years and older
Enrollment: 23 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Nicotine Dependence
Interventions: Cognitive Behavioural Therapy, Contingency Management, Nicotine Transdermal Patch; Behavioral · Drug
Lead sponsor: Yale University; Other
Eligibility: 14 Years to 19 Years
Enrollment: 154 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2015
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Use Disorder
Interventions: Pharmacotherapies for Smoking Cessation; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 20 Years to 65 Years
Enrollment: 293 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2006
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Substance Use Disorders, Alcohol Use Disorders, Recovery Support Services, Peer Recovery Coaching
Interventions: Training-as-Usual (TAU), TDPP-A (Asynchronous Platform), TDPP-Z (Hybrid), Localized TDPP (Maryland); Behavioral
Lead sponsor: Thrive Digital Health, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 450 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Solon, Ohio

Conditions: Smoking Cessation
Interventions: WeChat Quit Coach, Leaflet, Optional Nicotine Replacement Therapy (NRT) Patches or Lozenges; Behavioral · Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 80 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Tobacco Dependence
Interventions: CEASE, CEASE + BIO; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 865 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Lung Cancer, Tobacco Use Disorder, Breast Cancer, Colorectal Cancer, Prostate Cancer
Interventions: Nicotine Replacement Patch; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 146 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Tobacco Dependence
Interventions: C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker, Lung Cancer Screening; Behavioral · Drug · Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 50 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 3
States / cities: Baltimore, Maryland

Conditions: Tobacco Use Cessation
Interventions: 1-Call Quitline Counseling, 4-Call Quitline Counseling, Nicotine patch, Nicotine Patch and Nicotine Lozenge, SmokefreeTXT, No SmokefreeTXT, Financial Incentives for Treatment Engagement, No Financial Incentives for Treatment Engagement; Behavioral · Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 1,316 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Smoking Cessation
Interventions: Mobile EX cessation support, DC Quitline Support, Device Control; Behavioral
Lead sponsor: Truth Initiative; Other
Eligibility: 18 Years and older
Enrollment: 803 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Cannabis Use Disorder, Tobacco Use Disorder
Interventions: CUD Treatment, Tobacco Treatment; Behavioral
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 67 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 3
States / cities: Concord, New Hampshire • Lebanon, New Hampshire • Seattle, Washington

Conditions: Head and Neck Squamous Cell Carcinoma, Lung Non-Small Cell Carcinoma, Stage I Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8, Stage I Lung Cancer AJCC v8, Stage IA1 Lung Cancer AJCC v8, Stage IA2 Lung Cancer AJCC v8, Stage IA3 Lung Cancer AJCC v8, Stage IB Lung Cancer AJCC v8, Stage II Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8, Stage II Lung Cancer AJCC v8, Stage IIA Lung Cancer AJCC v8, Stage IIB Lung Cancer AJCC v8, Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8, Stage IIIC Lung Cancer AJCC v8, Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
Interventions: Best Practice, Nicotine Replacement, Quality-of-Life Assessment, Questionnaire Administration; Other · Drug
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Tobacco Use Cessation
Interventions: Quitline-Delivered Proactive Telephone Counseling, Follow-Up Phone Call, Smoking Cessation Training, Qualitative Interviews Concerning the Implementation of AAC; Behavioral
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 5,212 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2049
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Nicotine Use, Tobacco Use
Interventions: Nicotine cessation program; Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 18 Years and older
Enrollment: 204 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Cigarette Smoking
Interventions: Nicotine replacement therapy - transdermal nicotine patch, Tailored behavioral intervention, Tobacco quit line referral, Nicotine replacement therapy - nicotine gum, Nicotine replacement therapy - nicotine lozenge, Bupropion Sustained Release, Varenicline, Combination pharmacotherapy - transdermal nicotine patch + nicotine gum, Combination pharmacotherapy - transdermal nicotine patch + nicotine lozenge, Combination pharmacotherapy - transdermal nicotine patch + bupropion, Alcohol use risk reduction, Behavioral activation for the treatment of depression, Behavioral management of post-cessation weight gain; Drug · Behavioral
Lead sponsor: Iowa City Veterans Affairs Medical Center; Federal
Eligibility: 18 Years to 99 Years
Enrollment: 63 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Smoking, Cigarette
Interventions: Nicotine Replacement Therapy, Referral to AHEC/Quitline; Drug · Other
Lead sponsor: University of Florida; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 5
States / cities: Gainesville, Florida

Search by objective public record fields.

Kids Safe and Smokefree (KiSS)

Metabolism Informed Smoking Treatment: The MIST RCT

Nicotine Patch as an Adjunctive Intervention to Reduce Secondhand Smoke Among NICU Families

Precision Pharmacotherapy Smoking Cessation Program

Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine

Extinction Based Treatment for Nicotine Dependence

Smartphone Based Smoking Cessation Intervention

Financial Incentives for Smoking Cessation Among Mothers

Smoking Cessation Intervention

Enhancing a High School Based Smoking Cessation Program

Bupropion as an Adjunct to the Nicotine Patch Plus CBT

DEVELOPMENT OF A NOVEL PEER RECOVERY SUPPORTER TRAINING PLATFORM

WeChat Quit Coach Pilot Study

Assessment of Biomarkers in Children to Help Parents Quit Tobacco

Feasibility of Delivering a Quitline Based Smoking Cessation Intervention in Cancer Patients

Testing C-Raven, a Virtual Tobacco Cessation Intervention, in the Community

Improving Quitline Support Study

Study of Mobile Phone Support for the DC Tobacco Quitline

Clinical Trial Tobacco Marijuana

Pilot Trial of E Cigarettes in Pts Diagnosed With Cancer of the Head, Neck, and Lung

Ask Advise Connect (AAC) Harris Heath CPRIT

Developing a Scalable Tobacco Cessation Program for Cancer Survivors and Caregivers

Tailored Tobacco Quitline for Rural Veterans

Tobacco Use Treatment in Cancer Patients