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ClinicalTrials.gov public records Last synced Oct 14, 2026, 6:50 AM EDT

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Showing 409–421 of 421 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Nicotine replacement therapies (NRT) Clear all
Not listed Not applicable Interventional Accepts healthy volunteers

Treating Smokeless Tobacco Use in Rural Veterans

NCT02994082
View directory record Official record
Conditions
Smokeless Tobacco, Nicotine Dependence
Interventions
Tailored behavioral intervention, Behavioral activation for elevated depressive symptoms, Post-cessation weight gain management, Alcohol use risk reduction, Nicotine replacement therapy - transdermal nicotine patch, Nicotine replacement therapy - nicotine lozenge, Nicotine replacement therapy - nicotine gum, Bupropion sustained release, Varenicline, Combination nicotine replacement therapy, Combination nicotine replacement therapy + bupropion, Tobacco quit line, Educational materials
Behavioral · Drug
Lead sponsor
Mark Vander Weg
Federal
Eligibility
18 Years to 99 Years
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Oct 14, 2026, 6:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility of a Decision Aid for E-Cigarettes in Primary Care

NCT03836573
View directory record Official record
Conditions
Smoking, Cigarette, Smoking Cessation
Interventions
Smoking Cessation iPad Decision Aid Tool
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 100 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 22, 2019 · Synced Oct 14, 2026, 6:50 AM EDT
Completed Not applicable Interventional Results available

Smoking Cessation for Smokers With Sleep Problems

NCT01277887
View directory record Official record
Conditions
Nicotine Dependence, Cigarette Smoking, Insomnia
Interventions
Cognitive-Behavioral Counseling, Smoking Cessation Counseling
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 75 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 21, 2017 · Synced Oct 14, 2026, 6:50 AM EDT
Completed Phase 4 Interventional Results available

Helping Those With Mental Illness Quit Smoking

NCT01783912
View directory record Official record
Conditions
Smoking, Nicotine Dependence, Mental Disorders
Interventions
Cognitive / Motivational Individual Sessions, Attention Control Individual Sessions, Nicotine Patch, Group Curriculum
Behavioral · Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 29, 2016 · Synced Oct 14, 2026, 6:50 AM EDT
Terminated Phase 4 Interventional Results available

e-Cigarettes Versus NRT Gum for Smoking Cessation

NCT01925781
View directory record Official record
Conditions
Nicotine Addiction, Smoking Cessation
Interventions
Nicotine polacrilex, STAM 1100mAh CE4 eGo Clearomizer
Drug · Other
Lead sponsor
Creighton University
Other
Eligibility
19 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jan 14, 2016 · Synced Oct 14, 2026, 6:50 AM EDT
Completed Phase 3 Interventional Results available

Metabolism Informed Smoking Treatment: The MIST RCT

NCT04590404
View directory record Official record
Conditions
Smoking
Interventions
Post-discharge automated phone calls (IVR) with option to connect with a tobacco coach., Nicotine Replacement Therapy, Varenicline, Metabolism Informed Smoking Treatment (Nicotine metabolite ratio (NMR)-based selection of pharmacotherapy)
Behavioral · Drug · Other
Lead sponsor
Vanderbilt-Ingram Cancer Center
Other
Eligibility
18 Years and older
Enrollment
606 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Oct 14, 2026, 6:50 AM EDT
Completed Not applicable Interventional Results available

Smoking Treatment and Exercise Program for Underserved Populations (STEP UP)

NCT02873754
View directory record Official record
Conditions
Smoking
Interventions
Cognitive Behavioral Counseling, Mobile Contingency Management, Bupropion, Transdermal nicotine patch, Nicotine polacrilex, Nicotine lozenge
Behavioral · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 70 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 13, 2018 · Synced Oct 14, 2026, 6:50 AM EDT
Active, not recruiting Not applicable Interventional

A Pragmatic Trial of Chronic Disease Approaches to Ameliorate Tobacco Related Cardiovascular Disease Health Disparities

NCT05671380
View directory record Official record
Conditions
Tobacco Use Cessation, Cardiovascular Diseases, Tobacco Use, Smoking, Smoking Cessation
Interventions
Longitudinal Proactive Outreach (LPO)., Ask-Advice-Connect (AAC)
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
3
States / cities
Minneapolis, Minnesota • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 14, 2026, 6:50 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Nicotine Replacement and Counseling In Adolescents

NCT00625794
View directory record Official record
Conditions
Smoking Cessation
Interventions
Nicotine nasal spray, Smoking cessation counseling
Drug · Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
15 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 28, 2008 · Synced Oct 14, 2026, 6:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Smoking, Stress, and Mobile Technology

NCT04838236
View directory record Official record
Conditions
Smoking, Tobacco
Interventions
MASP app + NRT, QuitGuide app + NRT
Other
Lead sponsor
University of Houston
Other
Eligibility
18 Years and older
Enrollment
227 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
2
States / cities
Oklahoma City, Oklahoma • Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 16, 2025 · Synced Oct 14, 2026, 6:50 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Nicotine Patch as an Adjunctive Intervention to Reduce Secondhand Smoke Among NICU Families

NCT04045964
View directory record Official record
Conditions
Environmental Tobacco Smoke, Smoking Cessation
Interventions
nicotine replacement therapy (NRT), motivational advice, Quitline referral
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
Not listed
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 11, 2024 · Synced Oct 14, 2026, 6:50 AM EDT
Completed Not applicable Interventional

Patient Navigation-based Tobacco Harm Reduction Program Among Cancer Patients

NCT04972916
View directory record Official record
Conditions
Tobacco Use
Interventions
Patient navigation-based tobacco harm reduction intervention
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 11, 2022 · Synced Oct 14, 2026, 6:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study of Novel Smoking Cessation Interventions in Current and Former Injection Drug Users

NCT01334736
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Usual care, Lung age, Contingency Management, Lung age + Contingency Management
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 22, 2017 · Synced Oct 14, 2026, 6:50 AM EDT