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Conditions: Complications, Postoperative
Interventions: Drain; Device
Lead sponsor: Twin Cities Spine Center; Other
Eligibility: 18 Years to 70 Years
Enrollment: 975 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2040
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Gastroschisis
Interventions: SoC Staged Silo Closure, Peritoneal Dialysis Solution/Dextrose 1.5%; Procedure · Drug
Lead sponsor: University of Arkansas; Other
Eligibility: 0 Hours to 12 Hours
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Thyroglossal Duct Cysts
Interventions: Post-surgical drain, No post-surgical drain; Procedure
Lead sponsor: University of Rochester; Other
Eligibility: 3 Years to 17 Years
Enrollment: 178 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 5
States / cities: Los Angeles, California • Hartford, Connecticut • Chicago, Illinois + 2 more

Conditions: Primary Spontaneous Pneumothorax
Interventions: Early Chest Tube Removal, Standard Chest Tube Removal, Apical Chest Tube; Procedure · Device
Lead sponsor: Swedish Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Perioperative/Postoperative Complications, Prostate Cancer
Interventions: robot-assisted laparoscopic surgery, questionnaire administration, intraoperative complication management/prevention; Procedure · Other
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 18 Years and older · Male only
Enrollment: 191 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Duarte, California

Conditions: Osteoarthritis
Interventions: Wound drainage, Total Shoulder Arthroplasty; Procedure
Lead sponsor: Columbia University; Other
Eligibility: Not listed
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Drain Output After Breast Reduction Surgery, Breast Reductions
Interventions: IV TXA, Topical TXA, Topical saline; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Spinal Deformity
Interventions: Negative pressure wound therapy (NPWT); Device
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Lumbar Fusion
Interventions: Postoperative Drain Placement, No Postoperative Drain Placement; Other
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Empyema, Pleural, Parapneumonic Effusion
Interventions: Intrapleural Medications, Surgery, Pleural Sampling, Pleural fluid drainage, Protocol Image #1, Surgical Consultation, Protocol Image #2: Chest X-ray PA/Lateral, Quality of Life; Drug · Procedure · Radiation + 2 more
Lead sponsor: Swedish Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Obesity, Lumbar Spine Surgery
Interventions: Closed-Incision Negative-Pressure Therapy; Device
Lead sponsor: Norton Leatherman Spine Center; Other
Eligibility: 18 Years and older
Enrollment: 124 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Louisville, Kentucky

Conditions: Non-Muscle Invasive Bladder Carcinoma
Interventions: Accelerometry, BCG Solution, Electronic Health Record Review, Patient Discharge, Survey Administration; Procedure · Biological · Other + 1 more
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Periprosthetic Joint Infection (PJI)
Interventions: Ultrasound-triggered microbubble destruction with antibiotics; Drug
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 3
States / cities: Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania • Dallas, Texas

Conditions: Post-operative Complications, Surgical Site Infection, Surgical Wound Infection
Interventions: Prevena™ Incision Management System (PIMS), Standard-of-care Dressing; Device
Lead sponsor: KCI USA, Inc; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Pneumothorax
Interventions: Primary Surgery Group, Initial Non-operative management; Procedure
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 5 Years to 18 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Pancreatic Head Neoplasm, Delayed Gastric Emptying, Post Operative Ileus, Whipple Procedure
Interventions: pancreaticoduodenectomy; Procedure
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 230 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Macular Edema, Fibrosis of the Retina
Interventions: Ozurdex, Surgery, Anterior Chamber (AC) Tap; Drug · Procedure
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Atrial Fibrillation, Atrial Flutter, Cardiac Events
Interventions: Left Posterior Pericardiotomy; Procedure
Lead sponsor: Population Health Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 1,400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2031
U.S. locations: 1
States / cities: New York, New York

Conditions: Perfusion; Complications
Interventions: Nitroglycerin, Negative Pressure Wound Therapy/ Wound VAC, Fluorescent Angiography with indocyanine-green (not to exceed 5mg/kg), No treatment; Drug · Device · Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 99 Years · Female only
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Osteoarthritis, Bilateral Total Knee Arthroplasty
Interventions: Drain, No Drain; Procedure
Lead sponsor: Colorado Joint Replacement; Other
Eligibility: Up to 70 Years
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Esophageal Cancer Surgery, Esophagectomy, Delayed Gastric Emptying Following Procedure, Esophageal Diseases, Esophageal Achalasia, Pylorus Dysfunction, Esophageal Dysmotility
Interventions: Botulinum Toxin A (Botox ), Pyloromyotomy; Biological · Procedure
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older
Enrollment: 170 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Glaucoma
Interventions: Ologen; Procedure
Lead sponsor: The New York Eye & Ear Infirmary; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: ACDF Surgery
Interventions: Drain; Device
Lead sponsor: University of Nebraska; Other
Eligibility: 19 Years to 75 Years
Enrollment: 360 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Quality of Life
Interventions: Lumbar Drain; Device
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 170 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

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A Prospective, Randomized Comparison Of Drainage Techniques After One- Or Two-Level Open Posterior Lumbar Decompression Or Decompression And Fusion

Direct Peritoneal Resuscitation in Gastroschisis

Assessing Post-operative Outcomes After Children's Sistrunk Procedure With or Without a Drain

Early Chest Tube Removal After Surgery for Primary Spontaneous Pneumothorax: A Randomized Controlled Trial

Robotic Assisted Laparoscopic Prostatectomy With or Without Pelvic Drain Placement in Reducing Adverse Events After Surgery in Patients With Prostate Cancer

Closed Suction Drainage in Shoulder Arthroplasty

Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery

Incisional Negative Pressure Wound Therapy

Wound Drain After Lumbar Fusion Surgery

Management of Pleural Space Infections

WoundVac in Obese Patients Undergoing Lumbar Surgery

Studying the Relationship of Patient Positioning and Intravesical Bacillus Calmette Guerin Dwell Time to Improve the Treatment of Non-muscle Invasive Bladder Cancer

Periprosthetic Joint Infection Bubble Study

The Use of the Prevena™ Incision Management System on Post-Surgical Cesarean Section Incisions

Primary Versus Delayed Surgical Therapy for Pediatric Spontaneous Pneumothorax

Nasogastric Decompression Following Pancreaticoduodenectomy

Pro-permeability and Pro-fibrosis Factors in the Aqueous of Patients With Retinal Diseases

Pericardiotomy in Cardiac Surgery

The Effect of Nitroglycerin Ointment, Fluorescent Angiography, and Incisional Negative Pressure Wound Therapy on Mastectomy Skin Flap Perfusion-Related Problems

Outcomes Following Suction Drain and Non-suction Drain Assisted Total Knee Arthroplasty

Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy

The Effectiveness of Ologen® Collagen Matrix in Preventing Intraocular Pressure (IOP) Spikes After Ahmed Glaucoma Valve Surgery (AGV-FP7)

Post-operative Outcomes of Anterior Cervical Discectomy and Fusion Surgery With and Without Drain Placement

Lumbar Drain After Endoscopic Surgery of the Skull Base