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Conditions: Pain, Chronic Pain, Breakthrough Pain
Interventions: Fentanyl Buccal Tablets; Drug
Lead sponsor: Cephalon; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 218 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 33
States / cities: Birmingham, Alabama • Phoenix, Arizona • Anaheim, California + 29 more

Conditions: Post Operative Pain
Interventions: SABER-Bupivacaine (Part 1), SABER-Bupivacaine (Part 2), Saline Placebo, Bupivacaine HCl; Drug
Lead sponsor: Durect; Industry
Eligibility: 18 Years and older
Enrollment: 399 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 21
States / cities: Florence, Alabama • Sheffield, Alabama • Arcadia, California + 13 more

Conditions: Total Hip Arthroplasty
Interventions: Quadratus Lumborum Block (QLB), Standard of Care; Drug
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Fibromyalgia
Interventions: Traditional Acupuncture, Sham Acupuncture; Procedure
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years to 80 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Irvine, California

Conditions: HIV Infection, Pain, Drug Dependence
Interventions: Collaboration with an IT enabled nurse care manager, Education and academic detailing, Facilitated access to a specialist in addictions; Behavioral
Lead sponsor: Boston Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 2
States / cities: Atlanta, Georgia • Boston, Massachusetts

Conditions: Pain, Referred
Interventions: Bupivacaine, Morphine, Fentanyl, Epinephrine, Saline solution; Drug · Other
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 17 Years to 40 Years · Female only
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Pain
Interventions: Valdecoxib, COX Inhibitor; Drug
Lead sponsor: National Institute of Nursing Research (NINR); NIH
Eligibility: 7 Years to 35 Years
Enrollment: 96 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2006
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Cleft Palate Children
Interventions: Ultrasound-guided bilateral suprazygomatic maxillary nerve block, Local anesthetic infiltration of the palate; Procedure
Lead sponsor: Ann & Robert H Lurie Children's Hospital of Chicago; Other
Eligibility: 9 Months to 2 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Femoral Neck Fractures, Intertrochanteric Fractures, Femoral Shaft Fracture, Distal Femur Fracture, Patella Fracture, Tibial Shaft Fracture with or Without Associated Fibula Fracture, Ankle Fracture (bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Tibial Pilon Fracture, Talar Head, Neck, Body, or Process Fractures, Calcaneus Fractures, Lisfranc Injuries, Isolated or Multiple Metatarsal Fractures, Phalanx Fractures of the Foot, Single or Multiple, Clavicle Fractures, Proximal Humerus Fractures, Humeral Shaft Fractures, Distal Humerus Fractures (intra or Extra-articular), Olecranon Fractures, Radial Head or Neck Fractures, Elbow Fractures Involving a Combination of Fractures of the Radius and Uln, Forearm Fractures (both Bone Forearm Fractures, Isolated Ulnar Shaft, Isolated Radial Shaft), Distal Radius Fractures
Interventions: Opioid-free pain treatment; Other
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Hypogonadism, Opioid-Related Disorders, Male Infertility
Interventions: Clomiphene citrate, Placebo; Drug
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 65 Years · Male only
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Marijuana Usage, Opioid Use
Interventions: Vaporized Marijuana, Opioid Agonist, Placebo; Drug
Lead sponsor: Shanna Babalonis, PhD; Other
Eligibility: 18 Years to 50 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Persistent Post-surgical Pain, Acceptance and Commitment Therapy, Substance Use Disorder
Interventions: ACT (Acceptance and Commitment Therapy); Behavioral
Lead sponsor: Barbara A Rakel; Other
Eligibility: 18 Years and older
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Fractures, Closed, Pain, Postoperative, Pain Catastrophizing, Pain, Acute, Analgesia, Opioid Use, Acceptance and Commitment Therapy, Orthopedics, Analgesics, Opioid, Text Messaging
Interventions: Acceptance and Commitment Therapy Delivered via an Automated Mobile Messaging Robot; Behavioral
Lead sponsor: Christopher Anthony; Other
Eligibility: 18 Years to 100 Years
Enrollment: 82 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Breast Cancer, Breast Surgery, Opioid Use
Interventions: POINT Protocol, Usual care; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 109 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 2
States / cities: Los Angeles, California • Santa Monica, California

Conditions: Post Operative Pain
Interventions: Pain and standard side effect management for PNCA with basal method., Pain and standard side effect management with PNCA without basal, Pain and standard side effect management with IV on an as needed basis method.; Other
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 4 Years to 18 Years
Enrollment: 94 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Opioid Use, Unspecified
Interventions: Not listed
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 1,668 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Patent Ductus Arteriosus, Surgery, Necrotizing Enterocolitis, Intestinal Perforation
Interventions: pharmacologic treatment of the PDA, no pharmacologic treatment of the PDA, NSAID; Other · Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 5 Days to 14 Days
Enrollment: 202 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 13
States / cities: San Diego, California • San Francisco, California • San Jose, California + 9 more

Conditions: Pancreas Neoplasms
Interventions: COX-2 Inhibitor 6-8 weeks prior to surgery, COX-2 Inhibitor for 6 months prior to follow-up EUS or ERCP; Drug
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2012
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Dysmenorrhea
Interventions: Vipon, Ibuprofen; Device · Drug
Lead sponsor: Another Way Products; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 115 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2009
U.S. locations: 2
States / cities: Kansas City, Missouri

Conditions: Hypertension
Interventions: Acetaminophen, NSAID; Drug
Lead sponsor: St. Louis University; Other
Eligibility: 14 Years to 50 Years · Female only
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Postoperative Pain
Interventions: HTX-011, Luer lock applicator, Vial access device, Ibuprofen, Acetaminophen, Ketorolac; Drug · Device
Lead sponsor: Heron Therapeutics; Industry
Eligibility: 18 Years and older
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 5
States / cities: Anaheim, California • Pasadena, California • Draper, Utah + 2 more

Conditions: Hereditary Angioedema (HAE)
Interventions: Icatibant (30 mg); Drug
Lead sponsor: Shire; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: Glendale, California

Conditions: Nephrolithiasis
Interventions: Novel Nonopioid Pathway; Other
Lead sponsor: The Miriam Hospital; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Chronic Low Back Pain
Interventions: Pain EASE, Tailored exercise, Continued Care and Active Monitoring, Cognitive Behavioral Therapy (CBT), Spinal Manipulation Therapy (SMT), Yoga; Other · Procedure · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 2,529 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 19
States / cities: Phoenix, Arizona • Loma Linda, California • Long Beach, California + 16 more

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Open-Label Study to Evaluate the Effect of Treatment With Fentanyl Buccal Tablets on Pain Anxiety Symptoms When Used for the Management of Breakthrough Pain

Trial of Extended Release Bupivacaine for Pain Relief After Surgery

Quadratus Lumborum Block Versus Control for Total Hip Arthroplasty

Analgesic Response to Opioids in Patients With Fibromyalgia After Conventional Acupuncture Versus Sham Acupuncture

Targeting Effective Analgesia in Clinics for HIV - Intervention

Subcutaneous Bupivacaine Decrease Post-op Pain in Patients Undergoing C-Section

Genetic Basis For Variation In NSAID Analgesia In A Clinical Model Of Acute Pain

Suprazygomatic Maxillary Nerve Block in Cleft Palate Outcomes

Opioid-Free Pain Treatment in Trauma Patients

Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration

Opioid and Cannabinoid Interactions

Preventing Persistent Post-Surgical Pain and Opioid Use In At-Risk Veterans: Effect of ACT

Pain and Narcotic Usage After Orthopaedic Surgery

Postoperative Opt-In Narcotics Treatment in Breast

Parent Nurse Controlled Analgesic in Pediatric Patients With Developmental Delay

Effect of Opioid Shortage on Drug Selection

Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus

Use of Celecoxib in Patients With Intraductal Papillary Mucinous Neoplasms (IPMNs)

A Comparison Study of Pain Relief From Dysmenorrhea Between the Vipon Tampon and Ibuprofen

NSAID Use in Postpartum Hypertensive Women

Phase 2 Herniorrhaphy Study for Opioid Elimination

Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers

Evaluation of a Nonopioid Recovery Pathway Following Surgery for Kidney Stones

Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response