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ClinicalTrials.gov public records Last synced Oct 24, 2026, 2:40 AM EDT

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Showing 337–360 of 2,682 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: OPIOID Clear all
Recruiting Not applicable Interventional

The ENHANCE Project Toolkit

NCT07649278
View directory record Official record
Conditions
Substance Related Disorder, Drug Overdose, eHealth
Interventions
Connections mHealth Application
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 24, 2026, 2:40 AM EDT
Completed No phase listed Observational

Precision Opioid Care After Cesarean Delivery (PRECISE-CD)

NCT05280743
View directory record Official record
Conditions
Cesarean Section Complications, Opioid Use
Interventions
Oxycodone
Drug
Lead sponsor
Grace Lim, MD, MS
Other
Eligibility
18 Years and older · Female only
Enrollment
341 participants
Timeline
2022 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 5, 2024 · Synced Oct 24, 2026, 2:40 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Theory-based Social Media Intervention for Non-medical Use of Prescription Opioids in Young Adults

NCT06469749
View directory record Official record
Conditions
Young Adults, Past-3-month Non-medical Use of Prescription Opioids, Without Substance Use Disorders, Social Media Users
Interventions
Theory-based and peer-led intervention on Instagram
Behavioral
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years to 25 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Oct 24, 2026, 2:40 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

Effect of Gabapentin on Postoperative Opioid Analgesic Use and Pain in Adolescents Undergoing Tonsillectomy

NCT05024825
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Gabapentin, hydrocodone, acetaminophen and ibuprofen
Drug
Lead sponsor
Albany Medical College
Other
Eligibility
12 Years to 18 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Aug 27, 2021 · Synced Oct 24, 2026, 2:40 AM EDT
Not listed Phase 4 Interventional

Buprenorphine and Integrated HIV Care Evaluation

NCT00124358
View directory record Official record
Conditions
Opioid-Related Disorders, HIV Infections, AIDS
Interventions
Buprenorphine, Integrated HIV care and office-based opioid dependence treatment
Drug · Behavioral
Lead sponsor
The New York Academy of Medicine
Other
Eligibility
18 Years and older
Enrollment
1,350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
10
States / cities
Tucson, Arizona • Oakland, California • San Francisco, California + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 27, 2007 · Synced Oct 24, 2026, 2:40 AM EDT
Completed No phase listed Observational

Vaccination Compliance

NCT03039725
View directory record Official record
Conditions
Vaccine Compliance
Interventions
Observational
Other
Lead sponsor
Jaye Shyken, MD
Other
Eligibility
14 Years to 55 Years · Female only
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 21, 2017 · Synced Oct 24, 2026, 2:40 AM EDT
Terminated Phase 4 Interventional Results available

Study of Using Long Acting Antihistamine to Treat Opioid Induced Itching

NCT01825655
View directory record Official record
Conditions
Pruritus
Interventions
Cetirizine, Placebo or sugar pill
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
6 Years to 18 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Buprenorphine/Naloxone in the Treatment of Heroin Dependence - 14

NCT00015340
View directory record Official record
Conditions
Opioid Dependence, Substance-Related Disorders
Interventions
Buprenorphine/naloxone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 59 Years
Enrollment
582 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2001
U.S. locations
5
States / cities
Los Angeles, California • Tampa, Florida • Hines, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 24, 2026, 2:40 AM EDT
Active, not recruiting Phase 3 Interventional

Understanding How Methadone Treatment During Surgery Affects Pain Levels and the Need for Pain Medications After Surgery

NCT05417100
View directory record Official record
Conditions
Spinal Surgery
Interventions
Methadone
Drug
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years to 75 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Not applicable Interventional

Evaluation of Pain Neuroscience Education for Patients Who Experience Chronic Pain With Concurrent Opioid Dependence

NCT06442306
View directory record Official record
Conditions
Chronic Pain, Opioid Dependence
Interventions
Pain Neuroscience Education, General Health Education
Other
Lead sponsor
Wichita State University
Other
Eligibility
18 Years to 95 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 4, 2024 · Synced Oct 24, 2026, 2:40 AM EDT
Recruiting Phase 4 Interventional

Pectoral Block in Breast Reduction for Pain Control

NCT07527039
View directory record Official record
Conditions
Macromastia (Symptomatic)
Interventions
Pectoral II Nerve Block, Post Operative Pain Relievers
Procedure · Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 75 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Increased Ketorolac Administration After Cesarean Section and Its Effect on Opioid Use: a Randomized Control Trial

NCT03678675
View directory record Official record
Conditions
Post-operative Pain, Post-partum Pain, Cesarean Section Complications
Interventions
Ketorolac
Drug
Lead sponsor
Tufts Medical Center
Other
Eligibility
16 Years and older · Female only
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 18, 2022 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Not applicable Interventional Results available

Best Practice Alert for Opioid Prescribing

NCT04446975
View directory record Official record
Conditions
Opioid Use
Interventions
BPA
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
21,689 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 4, 2024 · Synced Oct 24, 2026, 2:40 AM EDT
Terminated Phase 3 Interventional

Modafinil in Opioid Induced Sedation

NCT00267332
View directory record Official record
Conditions
Cancer, Pain
Interventions
Modafinil
Drug
Lead sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 7, 2018 · Synced Oct 24, 2026, 2:40 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

The Use of Lumbar Erector Spinae Plane Block for Hip Arthroplasty at the L4 Interspace

NCT03801863
View directory record Official record
Conditions
Hip Arthropathy, Regional Anesthesia
Interventions
Ultrasound-guided Erector Spinae Plane Block with Ropivacaine 0.375%, Ropivacaine
Procedure · Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 99 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 21, 2023 · Synced Oct 24, 2026, 2:40 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers Results available

Feasibility of Deep Brain Stimulation as a Novel Treatment for Refractory Opioid Use Disorder

NCT03950492
View directory record Official record
Conditions
Opioid-Related Disorders
Interventions
Deep Brain Simulator
Device
Lead sponsor
West Virginia University
Other
Eligibility
21 Years to 50 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jul 28, 2025 · Synced Oct 24, 2026, 2:40 AM EDT
Recruiting Not applicable Interventional

Postpartum Intervention for Mothers With Opioid Use Disorders (R33)

NCT07632053
View directory record Official record
Conditions
Opioid Use Disorder, Parent-Child Relations
Interventions
Mom Power
Behavioral
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Ann Arbor, Michigan • Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 24, 2026, 2:40 AM EDT
Completed No phase listed Observational

Kentucky Access to Recovery Evaluation

NCT05889702
View directory record Official record
Conditions
Substance Use Disorders, Treatment Adherence and Compliance
Interventions
KATR Linkage Strategy
Behavioral
Lead sponsor
Terry Bunn
Other
Eligibility
18 Years and older
Enrollment
458 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Berea, Kentucky • Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 16, 2025 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Phase 2 Interventional

Study Evaluating Oral MOA-728 for the Treatment of Opioid-Induced Bowel Dysfunction (OIBD) in Subjects With Chronic Non-Malignant Pain

NCT00366431
View directory record Official record
Conditions
Constipation
Interventions
MOA-728
Drug
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
67
States / cities
Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 53 more
Source: ClinicalTrials.gov public record
Updated Nov 25, 2019 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Not applicable Interventional

Opioid Use After Urogynecologic Procedures: Using a Predictive Calculator

NCT05571072
View directory record Official record
Conditions
Post Operative Pain, Opioid Use, Prolapse Genital
Interventions
Opioid calculator, Standard opioid prescription
Other
Lead sponsor
David Sheyn
Other
Eligibility
18 Years to 89 Years · Female only
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 21, 2024 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Phase 2 Interventional Results available

Induction of Opioid-Dependent Individuals Onto Buprenorphine and Buprenorphine/Naloxone

NCT00637000
View directory record Official record
Conditions
Opioid-related Disorders
Interventions
Buprenorphine soluble film, Buprenorphine/naloxone film strip, Placebo
Drug
Lead sponsor
Indivior Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 5, 2017 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Phase 2 Interventional Results available

Heart Rate Variability in Response to Metformin Challenge

NCT02500628
View directory record Official record
Conditions
Fibromyalgia, Mitochondrial Diseases, Movement Disorders, Diabetes Mellitus, Type 2
Interventions
Metformin
Drug
Lead sponsor
Woodinville Psychiatric Associates
Other
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Woodinville, Washington
Source: ClinicalTrials.gov public record
Updated Jan 3, 2018 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Not applicable Interventional Results available

Data-driven Identification for Substance Misuse

NCT03833804
View directory record Official record
Conditions
Substance Use, Substance Abuse, Substance-Related Disorders
Interventions
Processing of clinical notes in the EHR data collected during routine care
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 89 Years
Enrollment
64,996 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 24, 2025 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Tranexamic Acid (TXA) Administered Prior to Shoulder Arthroscopy on Postoperative Pain Medication Usage: A Randomized Controlled Trial

NCT06920264
View directory record Official record
Conditions
This Study Will Evaluate Whether TXA Reduces Pain
Interventions
Tranexamic acid, placebo
Drug · Other
Lead sponsor
St. Louis Joint Replacement Institute
Other
Eligibility
Not listed
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Bridgeton, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Oct 24, 2026, 2:40 AM EDT