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ClinicalTrials.gov public records Last synced Oct 29, 2026, 10:37 PM EDT

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Showing 985–1008 of 2,686 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: OPIOID Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression

NCT04301895
View directory record Official record
Conditions
Opioid; Intoxication, Perception Disturbance (Acute), Acute Pain, Overdose of Opiate, Respiratory Depression, Safety Issues
Interventions
Continuous conversational interaction, Remifentanil infusion
Behavioral · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
20 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 10, 2020 · Synced Oct 29, 2026, 10:37 PM EDT
Completed Phase 3 Interventional Results available

Perioperative Pregabalin in Ureteroscopy: a Pilot

NCT03927781
View directory record Official record
Conditions
Nephrolithiasis, Urolithiasis, Perioperative/Postoperative Complications, Pain, Postoperative, Pain, Acute, Anesthesia, Urologic Diseases, Anesthesia Morbidity
Interventions
Pregabalin 300mg
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 19, 2021 · Synced Oct 29, 2026, 10:37 PM EDT
Recruiting Phase 2 Interventional

MDMA for Co-occurring PTSD and OUD After Childbirth

NCT05219175
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Opioid Use Disorder
Interventions
MDMA Assisted Therapy
Drug
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Oct 29, 2026, 10:37 PM EDT
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

NOTRE: Optimizing Long-Acting Pre-Exposure Prophylaxis and Medications for Opioid Use Disorder Interventions in Carceral Settings

NCT06854029
View directory record Official record
Conditions
HIV Infections, Opioid Use Disorder, Incarceration; Lens
Interventions
Cabotegravir Injection, Cabotegravir Pill, Buprenorphine injection, Buprenorphine Pill
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 29, 2026, 10:37 PM EDT
Completed Phase 3 Interventional Results available

Treatment Seeking Participants With Opioid Use Disorders Assessing Tolerability of Depot Injections of Buprenorphine

NCT02357901
View directory record Official record
Conditions
Opioid Dependence, Opioid Related Disorders
Interventions
SUBOXONE, RBP-6000, Placebo
Drug
Lead sponsor
Indivior Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
665 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
38
States / cities
Haleyville, Alabama • Hamilton, Alabama • Little Rock, Arkansas + 33 more
Source: ClinicalTrials.gov public record
Updated Feb 20, 2018 · Synced Oct 29, 2026, 10:37 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System

NCT07498322
View directory record Official record
Conditions
Opiod Use Disorder
Interventions
OUD screening, MOUD, Continuity of care
Other
Lead sponsor
University of Illinois Chicago
Other
Eligibility
16 Years and older
Enrollment
271,031 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 29, 2026, 10:37 PM EDT
Recruiting Phase 4 Interventional

Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

NCT03858231
View directory record Official record
Conditions
Knee Injuries, Pain, Postoperative, Opioid Use
Interventions
Norco 5Mg-325Mg Tablet, Ibuprofen 600 mg, Acetaminophen 325Mg Tab
Drug
Lead sponsor
Sanford Health
Other
Eligibility
18 Years to 80 Years
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Oct 29, 2026, 10:37 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Overcoming Stigma and Improving Outcomes for SUDs Through Education, Engagement, and Empowerment

NCT06266572
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Overcoming and Addressing Stigma in Substance Use Disorders (OASIS)
Behavioral
Lead sponsor
Center for Social Innovation, Massachusetts
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 1, 2024 · Synced Oct 29, 2026, 10:37 PM EDT
Completed Not applicable Interventional Results available

Default Dosing Settings for Opioid Prescriptions to Adolescents and Young Adults After Tonsillectomy

NCT04066829
View directory record Official record
Conditions
Tonsillectomy
Interventions
Default setting intervention
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
12 Years to 25 Years
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 1, 2022 · Synced Oct 29, 2026, 10:37 PM EDT
Withdrawn Phase 2 Interventional

Treatment of Chronic Itch in Atopic Dermatitis With Opioid Antagonist Naltrexone

NCT04325802
View directory record Official record
Conditions
Atopic Dermatitis, Pruritus, Pruritus Chronic, Dermatitis
Interventions
Naltrexone, Placebo
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Oct 29, 2026, 10:37 PM EDT
Completed Phase 2 Interventional Results available

Efficacy and Safety Study Evaluating ADL5859 and ADL5747 in Participants With Pain Due to Osteoarthritis of the Knee

NCT00979953
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
ADL5859, ADL5747, Oxycodone CR, Placebo
Drug
Lead sponsor
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Industry
Eligibility
18 Years to 75 Years
Enrollment
408 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
11
States / cities
Daytona Beach, Florida • Stockbridge, Georgia • Chicago, Illinois + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2015 · Synced Oct 29, 2026, 10:37 PM EDT
Completed Not applicable Interventional

Paravertebral Catheters for Pancreatic Surgery

NCT02363777
View directory record Official record
Conditions
Acute Pain
Interventions
Epidural, Paravertebral catheters
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 31, 2017 · Synced Oct 29, 2026, 10:37 PM EDT
Completed Not applicable Interventional Results available

Best Practice Alert for Opioid Prescribing

NCT04446975
View directory record Official record
Conditions
Opioid Use
Interventions
BPA
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
21,689 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 4, 2024 · Synced Oct 29, 2026, 10:37 PM EDT
Completed Phase 4 Interventional Results available

Intravenous Acetaminophen in Craniotomy

NCT01598701
View directory record Official record
Conditions
Postoperative Pain
Interventions
Acetaminophen, Placebo
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 120 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 29, 2026, 10:37 PM EDT
Completed Not applicable Interventional

Comparing the Impact of Mindful Interoceptive Mapping and Mindful Breathing on Pain and Opioid Use

NCT04523766
View directory record Official record
Conditions
Pain, Chronic, Opioid Use
Interventions
Mindfulness of Breath, Mindful Interoceptive Mapping
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 26, 2024 · Synced Oct 29, 2026, 10:37 PM EDT
Completed Not applicable Interventional Results available

Spine Pain INtervention to Enhance Care Quality And Reduce Expenditure

NCT03083886
View directory record Official record
Conditions
Back Pain, Neck Pain
Interventions
Identify, Coordinated, Enhanced (ICE) Decision Making + PCP led care, Individualized Postural Therapy (IPT) + PCP led care, Usual PCP led care
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
3,087 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
8
States / cities
Phoenix, Arizona • Laguna Hills, California • North Hollywood, California + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Oct 29, 2026, 10:37 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Can Post-operative TAP Block Improve Quality of Recovery After C-sections in Patients on Methadone Maintenance?

NCT01644864
View directory record Official record
Conditions
Uncontrolled Postoperative Pain
Interventions
0.375% ROPIVACAINE, placebo
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 40 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 8, 2017 · Synced Oct 29, 2026, 10:37 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

The Pittsburgh Study Early Childhood

NCT05444205
View directory record Official record
Conditions
Child Development, Child Language, Child Behavior Problem, Parenting, Parent Child Abuse
Interventions
Text4Baby or Bright by Text Referral, Nurture Program Warm Referral, Video Interaction Project, Family Check-UP, Smart Beginnings, Healthy Families America Warm Referral, Family Center Warm Referral
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
Up to 6 Years
Enrollment
2,546 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
5
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 29, 2026, 10:37 PM EDT
Completed Not applicable Interventional

Rural Expanded Access to OUD Care & Linkage Using Toxicologists for Telehealth Initiated Treatment

NCT05711056
View directory record Official record
Conditions
Opioid Use, Opioid Abuse
Interventions
Sociobehavioral Intervention
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
163 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 29, 2026 · Synced Oct 29, 2026, 10:37 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

In Vitro Studies on Pharmacological Regulation and Genetic Risk Factors of Peripheral Human Nociceptors

NCT00223366
View directory record Official record
Conditions
Pain
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
16 Years to 90 Years
Enrollment
2,007 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2019
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Oct 29, 2026, 10:37 PM EDT
Completed Phase 4 Interventional Results available

Intrathecal Opioids for Pain Control After Cesarean Delivery: Determining the Optimal Dose

NCT02009722
View directory record Official record
Conditions
Analgesia, Obstetrical, Cesarean Section
Interventions
Morphine, Hydromorphone
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 25, 2016 · Synced Oct 29, 2026, 10:37 PM EDT
Completed Phase 2 Interventional Results available

HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis

NCT04571619
View directory record Official record
Conditions
End Stage Renal Disease, Chronic Pain, Opioid Dependence
Interventions
Pain Coping Skills Training (PCST), Buprenorphine
Behavioral · Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years and older
Enrollment
643 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
16
States / cities
West Haven, Connecticut • Chicago, Illinois • Boston, Massachusetts + 11 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Oct 29, 2026, 10:37 PM EDT
Completed Phase 3 Interventional Results available

Opioid-induced Bowel Dysfunction (OBD) Pivotal Assessment of Lubiprostone (OPAL)

NCT01298219
View directory record Official record
Conditions
Opioid-induced Bowel Dysfunction
Interventions
Lubiprostone, Placebo
Drug
Lead sponsor
Sucampo Pharma Americas, LLC
Industry
Eligibility
18 Years and older
Enrollment
439 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
115
States / cities
Athens, Alabama • Birmingham, Alabama • Foley, Alabama + 89 more
Source: ClinicalTrials.gov public record
Updated Feb 11, 2020 · Synced Oct 29, 2026, 10:37 PM EDT
Withdrawn Phase 2 Interventional

Neurobiology of Opioid Dependence: 1 - 1

NCT00000192
View directory record Official record
Conditions
Opioid-Related Disorders
Interventions
Lamotrigine
Drug
Lead sponsor
Yale University
Other
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
1993 – 1998
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 7, 2015 · Synced Oct 29, 2026, 10:37 PM EDT