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ClinicalTrials.gov public records Last synced Oct 30, 2026, 4:09 PM EDT

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Showing 601–624 of 1,444 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: OPTIMAL Clear all
Completed Early Phase 1 Interventional

INJECT: A Pilot Study of Intra-tumoral Injections in Metastatic Urological Cancers

NCT03071328
View directory record Official record
Conditions
Metastatic Castration-resistant Prostate Cancer (mCRPC), Metastatic Urothelial Carcinoma, Metastatic Renal Cell Carcinoma
Interventions
Isovue-M 200
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Male only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 11, 2022 · Synced Oct 30, 2026, 4:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessment of Optimal Egg Intake in a Healthy Population

NCT02531958
View directory record Official record
Conditions
Cardiovascular Disease
Interventions
Eggs
Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 30 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 27, 2017 · Synced Oct 30, 2026, 4:09 PM EDT
Recruiting Phase 1Phase 2 Interventional

Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers

NCT02584244
View directory record Official record
Conditions
Colorectal Cancer, Pancreatic Cancer, Esophageal Cancer, Gastric Cancer
Interventions
LUM015, LUM 2.6 Imaging Device
Drug · Device
Lead sponsor
Lumicell, Inc.
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 16, 2026 · Synced Oct 30, 2026, 4:09 PM EDT
Completed Phase 1 Interventional Results available

Feasibility of a Systems Approach for Alzheimer's Services Among Latinos Attending Primary Care Practices

NCT04418232
View directory record Official record
Conditions
Dementia
Interventions
Alianza Latina
Combination Product
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
243 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 30, 2026, 4:09 PM EDT
Withdrawn No phase listed Observational

Catheter Ablation for Atrial Fibrillation and Heart Failure

NCT01082601
View directory record Official record
Conditions
Congestive Heart Failure, Atrial Fibrillation, Arrhythmia
Interventions
Pulmonary Vein Isolation (PVI)
Procedure
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
2
States / cities
Ridgewood, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 17, 2012 · Synced Oct 30, 2026, 4:09 PM EDT
Completed No phase listed Observational

Positive Predictive Value of the Dx-pH Probe for Predicting PPI Response in LPR

NCT01755221
View directory record Official record
Conditions
Laryngopharyngeal Reflux (LPR), Extraesophageal Reflux, Reflux Laryngitis, Posterior Laryngitis
Interventions
Not listed
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 89 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Oct 30, 2026, 4:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adequate Dairy Intake on Weight Change in Girls

NCT01066806
View directory record Official record
Conditions
Obesity
Interventions
counseling on increasing calcium intake, observation
Behavioral · Other
Lead sponsor
Creighton University
Other
Eligibility
13 Years to 14 Years · Female only
Enrollment
274 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 22, 2016 · Synced Oct 30, 2026, 4:09 PM EDT
Completed Not applicable Interventional

Debulking Surgery in Ovarian Cancer

NCT03378128
View directory record Official record
Conditions
Malignant Neoplasm of Ovary, Malignant Neoplasm of Fallopian Tube, Malignant Neoplasm of Peritoneum
Interventions
Diagnostic laparoscopy
Procedure
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
19 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Charlotte, North Carolina • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 14, 2022 · Synced Oct 30, 2026, 4:09 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Infertility Therapy for Women Age Thirty-eight and Older

NCT00246506
View directory record Official record
Conditions
Infertility
Interventions
intrauterine insemination, in vitro fertilization
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
38 Years to 43 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2013
U.S. locations
4
States / cities
Boston, Massachusetts • Brookline, Massachusetts • Quincy, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 15, 2013 · Synced Oct 30, 2026, 4:09 PM EDT
Active, not recruiting Not applicable Interventional

Therapy and Peer Support for Patients Taking Medication for Opioid Use Disorder

NCT06359340
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Psychosocial treatment
Behavioral
Lead sponsor
Public Health Management Corporation
Other
Eligibility
18 Years and older
Enrollment
440 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Oct 30, 2026, 4:09 PM EDT
Recruiting Not applicable Interventional

Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices

NCT07541417
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Certified Peer Support Specialist Intervention
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
750 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Oct 30, 2026, 4:09 PM EDT
Terminated Not applicable Interventional

Proactive Therapeutic Drug Monitoring Based Adalimumab Therapy Optimization in Patients With Rheumatoid Arthritis

NCT05460390
View directory record Official record
Conditions
Rheumatoid Arthritis
Interventions
Therapeutic drug monitoring (TDM)
Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 10, 2024 · Synced Oct 30, 2026, 4:09 PM EDT
Recruiting Phase 2 Interventional

Clinical Trial of BP1001 in Combination With With Venetoclax Plus Decitabine in AML

NCT02781883
View directory record Official record
Conditions
Acute Myeloid Leukemia (AML)
Interventions
BP1001 in combination with Ventoclax plus decitabine, BP1001 plus decitabine
Drug
Lead sponsor
Bio-Path Holdings, Inc.
Industry
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2028
U.S. locations
9
States / cities
Los Angeles, California • Augusta, Georgia • Fairway, Kansas + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 7, 2025 · Synced Oct 30, 2026, 4:09 PM EDT
Completed Phase 4 Interventional Results available

Randomized Trial of Sedative Choice for Intubation

NCT05277896
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Ketamine, Etomidate
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
2,367 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
6
States / cities
Birmingham, Alabama • Aurora, Colorado • Denver, Colorado + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 30, 2026, 4:09 PM EDT
Completed Not applicable Interventional Results available

Optimizing Health From Pregnancy Through One Year Postpartum

NCT03069690
View directory record Official record
Conditions
Obesity, Pregnancy Related
Interventions
HABITpreg, HABITpost
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years and older · Female only
Enrollment
320 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 16, 2025 · Synced Oct 30, 2026, 4:09 PM EDT
Active, not recruiting Phase 2Phase 3 Interventional

Comparison of Chemotherapy Before and After Surgery Versus After Surgery Alone for the Treatment of Gallbladder Cancer

NCT04559139
View directory record Official record
Conditions
Stage II Gallbladder Cancer AJCC v8, Stage IIA Gallbladder Cancer AJCC v8, Stage IIB Gallbladder Cancer AJCC v8, Stage III Gallbladder Cancer AJCC v8, Stage IIIA Gallbladder Cancer AJCC v8, Stage IIIB Gallbladder Cancer AJCC v8
Interventions
Cisplatin, Gemcitabine Hydrochloride, Lymphadenectomy, Partial Hepatectomy
Drug · Procedure
Lead sponsor
ECOG-ACRIN Cancer Research Group
Network
Eligibility
18 Years and older
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2029
U.S. locations
367
States / cities
Birmingham, Alabama • Anchorage, Alaska • Phoenix, Arizona + 253 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 30, 2026, 4:09 PM EDT
Withdrawn Not applicable Interventional

Clinical Evaluation of the Ultrasound-Guided Retroclavicular Brachial Plexus Block

NCT01605929
View directory record Official record
Conditions
Anesthesia, Upper Extremity Injury
Interventions
Retroclavicular Brachial Plexus Block and Catheter Insertion
Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 7, 2015 · Synced Oct 30, 2026, 4:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Real-Time Caffeine Optimization During Total Sleep Deprivation

NCT04399083
View directory record Official record
Conditions
Caffeine, Sleep Deprivation, Shift-Work Related Sleep Disturbance
Interventions
Caffeine
Dietary Supplement
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 39 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 17, 2021 · Synced Oct 30, 2026, 4:09 PM EDT
Completed Not applicable Interventional

Comparing NAVA Levels in Intubated and Recently Extubated Neonates to Determine Optimal Non-invasive Ventilatory Support

NCT02048280
View directory record Official record
Conditions
Other Specified Respiratory Problems in Fetus or Neonate
Interventions
NAVA level, NAVA level
Procedure · Other
Lead sponsor
ProMedica Health System
Other
Eligibility
23 Weeks to 40 Weeks
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 30, 2015 · Synced Oct 30, 2026, 4:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Promoting Optimal Healing After Laceration Repair Study

NCT02055794
View directory record Official record
Conditions
Neuralgia, Perineal
Interventions
Suturing of the perineal skin, Closing perineal skin with surgical glue, No suturing of the perineal skin
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 5, 2017 · Synced Oct 30, 2026, 4:09 PM EDT
Active, not recruiting Not applicable Interventional

Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

NCT02661451
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
SAPIEN 3 THV, Optimal Heart Failure Therapy
Device · Biological
Lead sponsor
Cardiovascular Research Foundation, New York
Other
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
46
States / cities
Chandler, Arizona • La Jolla, California • Los Angeles, California + 37 more
Source: ClinicalTrials.gov public record
Updated Nov 27, 2024 · Synced Oct 30, 2026, 4:09 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Maneuvers to Reduce Laparoscopic Pain

NCT07583433
View directory record Official record
Conditions
Laparoscopic Surgery, Post Operative Pain, Acute, Pneumoperitoneum
Interventions
Smoke Evacuation Group, Recruitment Breath Group, Control Group
Procedure
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 30, 2026, 4:09 PM EDT
Recruiting Not applicable Interventional

RCT of Sensor-controlled Digital Game for Hypertension Self-care in a Native American Community

NCT05671406
View directory record Official record
Conditions
Hypertension
Interventions
Sensor-controlled digital game, Sensor only
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Oct 30, 2026, 4:09 PM EDT
Completed Phase 4 Interventional Results available

CONCERTA Lab School Study

NCT00799487
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder
Interventions
CONCERTA (methylphenidate HCl) or placebo
Drug
Lead sponsor
Ortho-McNeil Janssen Scientific Affairs, LLC
Industry
Eligibility
9 Years to 12 Years
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
3
States / cities
Little Rock, Arkansas • Las Vegas, Nevada • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 12, 2020 · Synced Oct 30, 2026, 4:09 PM EDT