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ClinicalTrials.gov public records Last synced Nov 7, 2026, 6:01 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 212 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: OUD Clear all

Conditions: Human Immunodeficiency Virus, Opioid Use Disorder
Interventions: Combined LAI Treatment: Cabenuva and Sublocade; Drug
Lead sponsor: Rhode Island Hospital; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Opioid Use Disorder
Interventions: EMBED CDS, Nurse prompt to complete COWS, Provider Prompt, Patient facing materials, Optimized EMBED, Name of Intervention; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 1,912 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 3
States / cities: Guilford, Connecticut • New Haven, Connecticut

Conditions: Opioid Use Disorder
Interventions: Extended-release Buprenorphine; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Opioid Use Disorder
Interventions: Exablate Model 4000 Type 2.0/2.1; Device
Lead sponsor: West Virginia University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Morgantown, West Virginia

Conditions: Opioid-use Disorder, Pain
Interventions: Exercise, Psychotherapy for Pain (I-STOP); Behavioral
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 2
States / cities: Denver, Colorado • Cleveland, Ohio

Conditions: Hepatitis C, Chronic, Opioid-use Disorder
Interventions: Sofosbuvir/Velpatasvir; Drug
Lead sponsor: Elizabeth Krans, MD; Other
Eligibility: 18 Years and older · Female only
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Withdrawal Symptoms, Opioid Use Disorder, Opioid Use
Interventions: Transcutaneous Cervical Vagal Nerve Stimulation, Sham Stimulation, [F-18]Fallypride; Device · Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 103 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 6
States / cities: Atlanta, Georgia

Conditions: Schizophrenia, Cannabis Dependence, Prodromal for Psychotic Illness, Family History of Alcoholism, Healthy Control, Opioid-use Disorder, Post Traumatic Stress Disorder
Interventions: [11-C]OMAR; Radiation
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 55 Years · Male only
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2026
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Opioid Use Disorder
Interventions: Buprenorphine; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Risky Health Behavior, Substance Use Disorders, Substance Abuse, Alcohol Use Disorder, Drinking, Alcohol, Substance Use
Interventions: Practice Facilitation (PF), Learning Collaborative (LC), Performance Incentives (PI); Other
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older
Enrollment: 144 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 3
States / cities: Cincinnati, Ohio • Columbus, Ohio

Conditions: Opioid Use Disorder, Chronic Back Pain, Anxiety
Interventions: low intensity focused ultrasound (LIFU); Device
Lead sponsor: Washington D.C. Veterans Affairs Medical Center; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Substance Use, Substance Use Disorders, Opioid-use Disorder, Peer Delivered, Medication for Opioid Use Disorder (MOUD), Methadone Treatment, Retention in Care, Behavioral Activation
Interventions: Peer-Delivered Behavioral Activation (Peer Activate); Behavioral
Lead sponsor: University of Maryland, College Park; Other
Eligibility: 18 Years and older
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 2
States / cities: Baltimore, Maryland • College Park, Maryland

Conditions: Opioid Use Disorder (OUD)
Interventions: Communities That HEAL, Wait-list control; Other
Lead sponsor: RTI International; Other
Eligibility: Not listed
Enrollment: 67 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 4
States / cities: Lexington, Kentucky • Boston, Massachusetts • New York, New York + 1 more

Conditions: Opioid-use Disorder
Interventions: Mindfulness-Based Relapse Prevention - Rolling Admission (MBRP-RA), Treatment-As-Usual; Behavioral
Lead sponsor: West Chester University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 105 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: West Chester, Pennsylvania

Conditions: Opioid Use Disorder
Interventions: OUD Telehealth Platform; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Contraceptive Usage, Contraception
Interventions: SexHealth Mobile; Behavioral
Lead sponsor: Children's Mercy Hospital Kansas City; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 98 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 4
States / cities: Kansas City, Missouri

Conditions: Opioid-use Disorder
Interventions: Empower Neuromodulation System; Device
Lead sponsor: Theranova, L.L.C.; Industry
Eligibility: 18 Years to 100 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Opioid Use Disorder
Interventions: Maternal Opioid use Disorder Management and Care Resources (MOM CARE) in Custody; Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid Use Disorder, Injection Related Infections, Stimulant Use Disorder
Interventions: Integrated Infectious Diseases and Substance Use Disorder Clinic (IC); Behavioral
Lead sponsor: Elana Rosenthal; Other
Eligibility: 18 Years and older
Enrollment: 304 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 4
States / cities: Washington D.C., District of Columbia • Atlanta, Georgia • Baltimore, Maryland + 1 more

Conditions: Opioid Use Disorder
Interventions: Psilocybin (high dose), psilocybin (low dose); Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 60 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Opioid Use Disorder
Interventions: RecoveryPad platform; Device
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 470 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Opioid-Use Disorder
Interventions: Placebo, TRV734, Oxycodone; Other · Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 75 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Post Operative Pain, Opioid Use, Unspecified
Interventions: Not listed
Lead sponsor: Boston Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Opioid-Related Disorders
Interventions: 18F-PI-2620 PET/CT; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 60 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Search by objective public record fields.

Combined Injectable Treatment for HIV and OUD

Adaptive Decision Support for Addiction Treatment Master

Extended-release Buprenorphine as a Novel Low-dose Induction Strategy

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD)

Enhancing Exercise and Psychotherapy to Treat Pain and Addiction in Opioid Use Disorders ("EXPO" Pilot Trial)

Sofosbuvir/Velpatasvir in Postpartum Women With Opioid Use Disorder and Chronic Hepatitis C Infection

Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3

Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning

Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use

The STop UNhealthy Substance Use Now Trial

Focused Ultrasound for the Complex Patient

Peer-Delivered Behavioral Activation for Methadone Adherence - Pilot Phase

HEALing Communities Study

Mindfulness-Based Relapse Prevention to Improve Medication Assisted Treatment Adherence and Drug-use Outcomes for Opioid Use Disorder

Telehealth Treatment for Opioid Use Disorders

SexHealth Mobile: Integrating a Mobile Clinic and a Point-of-care Contraception Counseling and Access

Pilot Research on Opioid Use Disorder

Piloting a Web Resource for Pregnancy OUD in Jail

Continuum of Care in Hospitalized Patients With Opioid/Stimulant Use Disorder and Infectious Complications From Drug Use

Psilocybin on Brain Mechanisms of Motivation in OUD

A Clinical Trial of Telehealth Treatment for Opioid Use Disorders

Biased Opioid Agonists for Treatment of Opioid Withdrawal in OUD

Sensory Outcomes in Active Substance Users

Tau PET Imaging in Opioid Use Disorder