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Conditions: Diabetic Foot Ulcer, Venous Leg Ulcer
Interventions: Urinary Bladder Matrix (UBM) sheet device for Venous Leg Ulcers, Urinary Bladder Matrix (UBM) sheet device for Diabetic Foot Ulcers, AmnioExcel Plus for Venous Leg Ulcers, AmnioExcel Plus for Diabetic Foot Ulcers, Standard of Care; Device · Procedure
Lead sponsor: Integra LifeSciences Corporation; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 13
States / cities: Los Angeles, California • San Francisco, California • Vista, California + 9 more

Conditions: Mohs Micrographic Surgery, Cutaneous Malignancy, Mohs Surgical Defect
Interventions: Control Dressing + Standard of Care, CAMP + Standard of Care; Other
Lead sponsor: BioLab Holdings; Industry
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Diabetic Foot Ulcer, Diabetic Foot
Interventions: Medaxis Debritom+, Sharp Surgical Debridement, Additional Outer Dressing Application, Offloading, Fibracol Wound Dressing; Other
Lead sponsor: Medaxis, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 222 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 6
States / cities: San Francisco, California • South Miami, Florida • Frederick, Maryland + 3 more

Conditions: Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU)
Interventions: DermaBind TL; Biological
Lead sponsor: HealthTech Wound Care; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 10
States / cities: DeLand, Florida • Palm Beach Gardens, Florida • Sweetwater, Florida + 7 more

Conditions: Diabetic Foot Ulcer, Ulcer Foot, Diabetic Foot
Interventions: Offloading, Additional (outer) Dressing Application, Mirragen Wound Matrix Dressing, Fibracol Wound Dressing; Other
Lead sponsor: ETS Wound Care, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 5
States / cities: St Louis, Missouri • Youngstown, Ohio • Martinsville, Virginia + 2 more

Conditions: Diabetic Foot Ulcer
Interventions: OptiPulse™, Standard of Care offloading device; Device
Lead sponsor: Compedica Inc; Industry
Eligibility: 18 Years and older
Enrollment: 162 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 18
States / cities: Phoenix, Arizona • Los Angeles, California • Vista, California + 12 more

Conditions: Diabetic Foot Ulcer
Interventions: PEP (Purified Exosome Product) / TISSEEL; Biological
Lead sponsor: Rion Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Blue Ash, Ohio

Conditions: Venous Leg Ulcer (VLU), Venous Leg Ulcers, Venous Leg, Nonhealing Venous Leg Ulcer
Interventions: Intact Fish Skin Graft (IFSG) + Standard of Care, Standard of Care; Other
Lead sponsor: Kerecis Ltd.; Industry
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Monroeville, Pennsylvania

Conditions: Diabetic Foot Ulcers
Interventions: EpiFix Mesh; Other
Lead sponsor: MiMedx Group, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Diabetic Foot Ulcers
Interventions: Affinity Allograft, Standard of care; Other
Lead sponsor: Organogenesis; Industry
Eligibility: 18 Years and older
Enrollment: 89 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 8
States / cities: Miami Lakes, Florida • North Miami Beach, Florida • Clinton Township, Michigan + 5 more

Conditions: Metatarsalgia, Hyperkeratotic Callus, Corns, Fat Pad Syndrome
Interventions: Juvederm Voluma; Device
Lead sponsor: Schoenhaus, Jodi, DPM; Individual
Eligibility: 40 Years to 75 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Boca Raton, Florida

Conditions: Diabetic Foot Ulcer, Amniotic Membrane Placental Allograft, Biologic
Interventions: Standard of Care, BIOxHEAL (human amniotic membrane allograft); Other · Biological
Lead sponsor: Applied Biologics, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 253 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Boardman, Ohio

Conditions: Diabetic Foot Ulcer
Interventions: Amnion-Intermediate-Chorion, Standard of Care (SOC); Other · Procedure
Lead sponsor: Cellution Biologics; Industry
Eligibility: 18 Years and older
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 8
States / cities: Santa Rosa, California • Jacksonville, Florida • Chicago, Illinois + 5 more

Conditions: Ankle Fractures
Interventions: Postoperative protocol (Immediate weight bearing), Postoperative Protocol (Delayed Weight Bearing); Other
Lead sponsor: Kyle Schweser MD; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2028
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Diabetic Foot, Ulcer Foot, Foot Ulcer, Diabetic Foot Ulcer
Interventions: Standard of Care, Axolotl DualGraft + SOC; Other
Lead sponsor: Axolotl Biologix; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Thousand Oaks, California

Conditions: Diabetic Foot Ulcers
Interventions: AMNIOEXCEL, Standard of Care, Diabetic Foot Ulcers; Other
Lead sponsor: Integra LifeSciences Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 8
States / cities: Phoenix, Arizona • Castro Valley, California • Stockton, California + 5 more

Conditions: Diabetic Foot Ulcers (DFUs), Diabetic Foot, Chronic Wounds
Interventions: Miro3D Wound Matrix, Standard of Care; Device · Other
Lead sponsor: Reprise Biomedical, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 14
States / cities: Phoenix, Arizona • Coconut Creek, Florida • Coral Gables, Florida + 9 more

Conditions: Pressure Ulcer, Ulcer, Pressure, Pressure Wound, Pressure Area
Interventions: Standard of Care, XPURT + SOC; Other
Lead sponsor: Applied Biologics, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Monroeville, Pennsylvania

Conditions: Diabetic Foot Ulcer
Interventions: Offloading Boot; Device
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 4
States / cities: Downey, California • Glendale, California • Los Angeles, California

Conditions: Diabetic Foot Ulcer
Interventions: SOC and Advanced Bioengineered Skin Substitute, SOC and Active Comparator; Device · Other
Lead sponsor: Encoll Corp; Industry
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 3
States / cities: Los Angeles, California • South Miami, Florida • Salem, Virginia

Conditions: Venous Leg Ulcer
Interventions: Affinity; Other
Lead sponsor: Organogenesis; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Carlsbad, California

Conditions: Diabetic Foot, Ulcer Foot
Interventions: Human split thickness skin allograft, Additional Outer Dressing Applicaiton, Offloading, Fibracol Wound Dressing; Other
Lead sponsor: Professional Education and Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 5
States / cities: San Francisco, California • O'Fallon, Illinois • Youngstown, Ohio + 2 more

Conditions: Diabetic Foot
Interventions: SkinTE, Control; Biological · Other
Lead sponsor: PolarityTE; Industry
Eligibility: 18 Years and older
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 13
States / cities: Fresno, California • Los Angeles, California • Hollywood, Florida + 8 more

Conditions: Open Wound
Interventions: NeoThelium FT; Other
Lead sponsor: NuScience Medical Biologics, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Hammond, Louisiana

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A Modified Platform Trial of Multiple CAMPs for the Management of Diabetic Foot Ulcers and Venous Leg Ulcers

Efficacy of a Novel Cellular, Acellular, Matrix-like Product (CAMP) Plus Standard of Care Versus Standard of Care Alone in the Management of Post-Mohs Micrographic Surgery Defects.

A Unique Micro Water Jet Technology Device Versus Standard Debridement in the Treatment of Diabetic Foot

A Non-Randomized Open Label Clinical Trial Evaluating DermaBind TL

Resorbable Glass Fiber Matrix in the Treatment of Diabetic Foot Ulcers

A Clinical Investigation Evaluating Wound Closure With OptiPulse™ Versus SOC in the Treatment of Non-Healing DFU's

Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU)

Evaluating Intact Fish Skin Graft and Standard of Care Versus Standard of Care Alone in Nonhealing Venous Leg Ulcers

dHACM Mesh In the Treatment of Diabetic Foot Ulcers

Effect of Fresh Amniotic Membrane in the Treatment of Diabetic Foot Ulcers

Pressure Offloading Injectible System With the Use of Juvederm Voluma in the Foot

a Prospective, Multicenter, Randomized Controlled Trial, With a Non-randomized Sentinel Cohort, Evaluating the Efficacy of Bioxheal, a Single-layer Placental-derived Biologic in Nonhealing Diabetic Foot Ulcers

Nonhealing Diabetic Foot Ulcers Treated With Standard of Care (SOC) Alone or Standard of Care and Amnion-Intermediate-Chorion (AIC)

Immediate Vs. Delayed Weight Bearing Postoperative Protocol in Diabetic Ankle Fractures

Dehydrated Human Amnion Membrane and Standard of Care Versus Standard of Care Alone in Nonhealing Diabetic Foot Ulcers

Phase IV Study to Evaluate the Efficacy of AMNIOEXCEL in Diabetic Foot Ulcers

Miro3D Wound Matrix for Treatment of Diabetic Foot Ulcers

A Multicenter, Prospective, Clinical Trial Evaluating a Single Layer Amniotic Membrane and Standard of Care Versus Matched Controls in the Management of Nonhealing Pressure Ulcers

Smart Boot Use to Measure Offloading Adherence

Clinical Study to Compare Two Skin Substitute Categories for Their Effectiveness to Treat Diabetic Foot Ulcers

Clinical Study Of Affinity Versus SOC In The Management Of VLUs

Bioactive Split Thickness Skin Allograft Versus Standard of Care in the Treatment of Diabetic Foot Ulcers

Multi-Center, Prospective, Randomized Controlled Trial Evaluating SkinTE® in the Treatment of Wagner 2 DFUs

Prospective Case Series Evaluating the Efficacy and Safety of NeoThelium FT for Open Wounds