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ClinicalTrials.gov public records Last synced Sep 1, 2026, 2:52 PM EDT

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Showing 1–24 of 1,342 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Opioid use Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Re-entry XR-NTX for Rural Individuals With Opioid Use Disorder

NCT03447743
View directory record Official record
Conditions
Opioid Dependence
Interventions
XR-NTX community location
Drug
Lead sponsor
Michele Staton
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 26, 2023 · Synced Sep 1, 2026, 2:52 PM EDT
Not yet recruiting Not applicable Interventional

Opioid Package Prototype (OPP)

NCT04598074
View directory record Official record
Conditions
Opioid Use, Opioid Prescribing, Dispensing, and Patient Use
Interventions
Opioid Package Prototype (OPP), Usual Care (standard amber vial)
Other
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
352 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Sep 1, 2026, 2:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Kentucky Women's Justice Community Opioid Innovation Network

NCT04069624
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
MOUD Pre-Treatment Telehealth, MOUD Pre-Treatment Telehealth and Peer Navigator, Services as Usual
Behavioral · Other
Lead sponsor
Michele Staton
Other
Eligibility
18 Years and older · Female only
Enrollment
900 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
9
States / cities
Elizabethtown, Kentucky • Harlan, Kentucky • Henderson, Kentucky + 6 more
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 1, 2026, 2:52 PM EDT
Terminated Phase 4 Interventional Results available

EXPAREL Administered by Infiltration Into the TAP for Prolonged Postsurgical Analgesia in Lower Abdominal Surgeries

NCT01919190
View directory record Official record
Conditions
Pain
Interventions
EXPAREL, Placebo
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
13
States / cities
Winter Park, Florida • Savannah, Georgia • Chicago, Illinois + 10 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2021 · Synced Sep 1, 2026, 2:52 PM EDT
Terminated Not applicable Interventional

Effectiveness of the Ivivi Torino II, Pulsed Radio Frequency Device, on Narcotic Use, Pain and Quality of Life Following Shoulder Arthroscopic Rotator Cuff Repair.

NCT01507818
View directory record Official record
Conditions
Rotator Cuff Tear
Interventions
Ivivi Torino II, Inactive Sham device
Device
Lead sponsor
Amp Orthopedics, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
3
States / cities
New Orleans, Louisiana • Jackson, Mississippi • Taos, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 8, 2012 · Synced Sep 1, 2026, 2:52 PM EDT
Completed No phase listed Observational

Prospective Evaluation of Intrathecal Targeted Drug Delivery for Cancer Associated Pain

NCT05674240
View directory record Official record
Conditions
Cancer Pain, Chronic Pain, Cancer Associated Pain, Neuropathic Pain
Interventions
Intrathecal Targeted Drug Delivery, Conservative medical management
Device · Combination Product
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Oshkosh, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 1, 2026, 2:52 PM EDT
Completed Not applicable Interventional

Clinical Research Study of the Benefits of BREG Polar Care Wave to Reduce Opioid Use by Patients Having Undergone Arthroscopic Rotator Cuff Repair Shoulder Surgery

NCT07455474
View directory record Official record
Conditions
Rotator Cuff Tear
Interventions
Breg Polar Care Wave Cold Compression Device
Device
Lead sponsor
University of Nevada, Reno
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Mammoth Lakes, California • Taos, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Sep 1, 2026, 2:52 PM EDT
Completed Phase 2Phase 3 Interventional

EXHIT ENTRE Comparative Effectiveness Trial

NCT04345718
View directory record Official record
Conditions
Substance Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
Interventions
Extended Release Buprenorphine, Treatment as Usual
Drug
Lead sponsor
Gavin Bart
Other
Eligibility
18 Years and older
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
6
States / cities
New Haven, Connecticut • Baltimore, Maryland • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Sep 1, 2026, 2:52 PM EDT
Completed No phase listed Observational

Critical Respiratory Events in Children Requiring Naloxone: Naloxone Use as Opioid Safety Measure

NCT01860885
View directory record Official record
Conditions
Opioid Induced Respiratory Depression
Interventions
Not listed
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
1 Day and older
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 22, 2013 · Synced Sep 1, 2026, 2:52 PM EDT
Completed No phase listed Observational

MOms in REcovery (MORE) Study: Defining Optimal Care

NCT04251208
View directory record Official record
Conditions
Opioid-Related Disorders, NAS, Substance Use Disorders
Interventions
Observational Study
Other
Lead sponsor
Trustees of Dartmouth College
Other
Eligibility
16 Years to 50 Years · Female only
Enrollment
444 participants
Timeline
2019 – 2024
U.S. locations
10
States / cities
Augusta, Maine • Bangor, Maine • Keene, New Hampshire + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2024 · Synced Sep 1, 2026, 2:52 PM EDT
Recruiting Not applicable Interventional

TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD)

NCT07171359
View directory record Official record
Conditions
Alcohol Use Disorder, Opioid Use Disorder
Interventions
TMS Low-Dose, TMS High-Dose
Device
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 1, 2026, 2:52 PM EDT
Recruiting Not applicable Interventional

Improving Outcomes for Early Postpartum Mothers in Outpatient MOUD Treatment

NCT07071766
View directory record Official record
Conditions
Substance Use Treatment, Perinatal Substance Use, Parenting
Interventions
Proud of Baby and Me
Behavioral
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 1, 2026, 2:52 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Prospective Randomized Trial of CPAP for SDB in Patients Who Use Opioids

NCT04928157
View directory record Official record
Conditions
Sleep Disorder; Breathing-Related, Pain, Sleep Apnea, Obstructive Sleep Apnea, Sleep, Sleep Disorder, Chronic Pain, Opioid Use
Interventions
Positive Airway Pressure (PAP)
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Dec 1, 2024 · Synced Sep 1, 2026, 2:52 PM EDT
Recruiting Not applicable Interventional

Evaluation of a Peer Recovery Support Program Adapted to Target Retention in Clinic-based Medication for Opioid Use Disorder Treatment

NCT07197801
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Peer recovery support to enhance patient engagement in medication for opioid use disorder treatment
Behavioral
Lead sponsor
Geisinger Clinic
Other
Eligibility
18 Years to 89 Years
Enrollment
218 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Danville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 1, 2026, 2:52 PM EDT
Completed Not applicable Interventional

Evaluating the Cost Effectiveness of STEADI

NCT05390736
View directory record Official record
Conditions
Accidental Fall
Interventions
Gait and balance assessment, Medication review, Comorbidity review, Fall history, Assessment of feet/footwear, Assessment of visual acuity, Home safety risk assessment, Vitamin D Deficiency
Behavioral
Lead sponsor
National Opinion Research Center
Other
Eligibility
65 Years and older
Enrollment
780 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 8, 2023 · Synced Sep 1, 2026, 2:52 PM EDT
Not listed Phase 4 Interventional

Pain Relief After Hiatal Hernia Repair Surgery

NCT04936711
View directory record Official record
Conditions
Shoulder Pain, Hiatal Hernia
Interventions
Resteck Shiatsu Neck and Back Massager, Marcaine
Device · Drug
Lead sponsor
Norton Thoracic Institute
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 22, 2021 · Synced Sep 1, 2026, 2:52 PM EDT
Recruiting Phase 2 Interventional

Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder

NCT06067737
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Psilocybin
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 70 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 1, 2026, 2:52 PM EDT
Completed Not applicable Interventional Results available

Co-Use of Opioid Medications and Alcohol Prevention Study

NCT05599672
View directory record Official record
Conditions
Alcohol Drinking, Opioid Use
Interventions
Alcohol-targeted Brief Intervention-Medication Therapy Management, Standard medication counseling
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Sep 1, 2026, 2:52 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Increased Ketorolac Administration After Cesarean Section and Its Effect on Opioid Use: a Randomized Control Trial

NCT03678675
View directory record Official record
Conditions
Post-operative Pain, Post-partum Pain, Cesarean Section Complications
Interventions
Ketorolac
Drug
Lead sponsor
Tufts Medical Center
Other
Eligibility
16 Years and older · Female only
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 17, 2022 · Synced Sep 1, 2026, 2:52 PM EDT
Withdrawn Early Phase 1 Interventional

Efficacy of Gabapentin in Prevention of Tourniquet Pain and Hypertension

NCT01441531
View directory record Official record
Conditions
Tourniquet-induced Pain, Tourniquet-induced Hypertension
Interventions
gabapentin 600 mg po, Placebo pill given one hour before surgery
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 16, 2015 · Synced Sep 1, 2026, 2:52 PM EDT
Completed Phase 4 Interventional Results available

Buprenorphine Extended-Release Subcutaneous Injection (RBP-6000) in High-risk Users

NCT04995029
View directory record Official record
Conditions
Moderate to Severe Opioid-use Disorder
Interventions
Transmucosal Buprenorphine, Extended-release Buprenorphine
Drug
Lead sponsor
Indivior Inc.
Industry
Eligibility
18 Years and older
Enrollment
785 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
28
States / cities
Garden Grove, California • Panorama City, California • San Diego, California + 21 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 1, 2026, 2:52 PM EDT
Completed Phase 2 Interventional Results available

Heart Rate Variability in Response to Metformin Challenge

NCT02500628
View directory record Official record
Conditions
Fibromyalgia, Mitochondrial Diseases, Movement Disorders, Diabetes Mellitus, Type 2
Interventions
Metformin
Drug
Lead sponsor
Woodinville Psychiatric Associates
Other
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Woodinville, Washington
Source: ClinicalTrials.gov public record
Updated Jan 2, 2018 · Synced Sep 1, 2026, 2:52 PM EDT
Recruiting Not applicable Interventional

Pivotal Study on the NOVABLOC System for Patients Undergoing Primary Total Knee Arthroplasty

NCT07191067
View directory record Official record
Conditions
Pain
Interventions
Percutaneous radiofrequency electrical nerve stimulation, Non-therapeutic stimulation
Device
Lead sponsor
Synaptrix, Inc.
Industry
Eligibility
21 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
5
States / cities
Daphne, Alabama • Williamsville, New York • Chapel Hill, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 1, 2026, 2:52 PM EDT
Recruiting Phase 2 Interventional

Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone

NCT04676802
View directory record Official record
Conditions
Pain, Postoperative, Osteoarthritis Thumb
Interventions
NSAID capsules, Opioid capsule
Drug
Lead sponsor
Stanford University
Other
Eligibility
45 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
2
States / cities
Redwood City, California • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Sep 1, 2026, 2:52 PM EDT