- Conditions
- Heroin Dependence, Opioid-Related Disorders
- Interventions
- Extended-Release Naltrexone
- Drug
- Lead sponsor
- NYU Langone Health
- Other
- Eligibility
- 18 Years to 99 Years
- Enrollment
- 217 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2014 – 2020
- U.S. locations
- 2
- States / cities
- New York, New York
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Showing 25–48
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- Conditions
- Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
- Interventions
- Buprenorphine
- Drug
- Lead sponsor
- Yale University
- Other
- Eligibility
- 21 Years to 55 Years
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2000 – 2004
- U.S. locations
- 1
- States / cities
- New Haven, Connecticut
- Conditions
- Opioid Use Disorder, Intimate Partner Violence (IPV), Post Traumatic Stress Disorder PTSD
- Interventions
- PCT+2HOPE
- Behavioral
- Lead sponsor
- Yale University
- Other
- Eligibility
- 18 Years and older · Female only
- Enrollment
- 532 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2029
- U.S. locations
- 3
- States / cities
- Bridgeport, Connecticut • Enfield, Connecticut • West Haven, Connecticut
- Conditions
- Acute Pain, Headache, Musculoskeletal Pain
- Interventions
- Usual Care/Guideline, Opioid Justification, Provider Comparison
- Behavioral
- Lead sponsor
- University of Pittsburgh
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 22,616 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2021
- U.S. locations
- 1
- States / cities
- Pittsburgh, Pennsylvania
- Conditions
- Opioid-use Disorder
- Interventions
- Collaborative Care (CC), Extension for Community Healthcare Outcomes (ECHO)
- Behavioral
- Lead sponsor
- Yale University
- Other
- Eligibility
- 18 Years and older · Female only
- Enrollment
- 230 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2024
- U.S. locations
- 11
- States / cities
- Hartford, Connecticut • New Britain, Connecticut • New Haven, Connecticut + 7 more
- Conditions
- Opioid Use Disorder, Cognitive Ability General
- Interventions
- Smartphone based cognitive tasks
- Behavioral
- Lead sponsor
- University of Maryland, Baltimore
- Other
- Eligibility
- 55 Years and older
- Enrollment
- 24 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2026
- U.S. locations
- 1
- States / cities
- Baltimore, Maryland
- Conditions
- Opiate Dependence, Sexually Transmitted Diseases, HIV
- Interventions
- Acceptance and Commitment Therapy, Information Motivation Behavioral Model
- Behavioral
- Lead sponsor
- Rhode Island Hospital
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 14 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2018
- U.S. locations
- 1
- States / cities
- Providence, Rhode Island
- Conditions
- Opioid Use Disorder, Chronic Pain
- Interventions
- Patient-Oriented Dosing (POD), Pain Self-Management (PSM), Usual Care, Standard Buprenorphine Dosing Condition
- Drug · Behavioral
- Lead sponsor
- Erin Winstanley
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 273 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2026
- U.S. locations
- 13
- States / cities
- Baltimore, Maryland • Dundalk, Maryland • Hagerstown, Maryland + 6 more
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Substance-Related Disorders
- Interventions
- opiates
- Drug
- Lead sponsor
- New York State Psychiatric Institute
- Other
- Eligibility
- 18 Years to 45 Years
- Enrollment
- 8 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 1995 – 2005
- U.S. locations
- 2
- States / cities
- New York, New York
- Conditions
- Alcohol Drinking
- Interventions
- Naltrexone and memantine first, Naltrexone and Placebo first
- Drug
- Lead sponsor
- Yale University
- Other
- Eligibility
- 21 Years to 55 Years
- Enrollment
- 75 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2017
- U.S. locations
- 1
- States / cities
- New Haven, Connecticut
- Conditions
- Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
- Interventions
- Community Reinforcement And Family Training (CRAFT), We The Village Peer Community Forum
- Behavioral
- Lead sponsor
- We The Village, Inc.
- Other
- Eligibility
- 19 Years and older
- Enrollment
- 45 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2020
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Substance Use Disorders, Infection, Soft Tissue, Bacteremia, Osteomyelitis Acute, Septic Arthritis
- Interventions
- Oritavancin
- Drug
- Lead sponsor
- University of Maryland, Baltimore
- Other
- Eligibility
- 18 Years to 88 Years
- Enrollment
- 1 participant
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2025
- U.S. locations
- 1
- States / cities
- Baltimore, Maryland
- Conditions
- Opioid Use Disorder, Substance Use Disorders, Stigma, Social
- Interventions
- Words Matter - Visual Campaign, Words Matter - Visual Campaign & Narrative Vignette (Messenger: Person with Opioid Use Disorder) Experimental: Words Matter - Visual Campaign & Narrative Vignette (Messenger: Clinician), Words Matter - Visual Campaign & Narrative Vignette (Messenger: Clinician), Words Matter - Visual Campaign & Narrative Vignette (Messenger: Health System Administrator), Medication Treatment for Opioid Use Disorder Works - Visual Campaign, Medication Treatment for Opioid Use Disorder Works - Visual Campaign & Narrative Vignette (Messenger: Person with Opioid Use Disorder), Medication Treatment for Opioid Use Disorder Works - Visual Campaign & Narrative Vignette (Messenger: Clinician), Medication Treatment for Opioid Use Disorder Works - Visual Campaign & Narrative Vignette (Messenger: Health System Administrator)
- Behavioral
- Lead sponsor
- Johns Hopkins Bloomberg School of Public Health
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 1,842 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2020
- U.S. locations
- 1
- States / cities
- Baltimore, Maryland
- Conditions
- Opioid-use Disorder
- Interventions
- Cannabidiol 100 MG/ML [Epidiolex], Placebo
- Drug
- Lead sponsor
- Brigham and Women's Hospital
- Other
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 15 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022
- U.S. locations
- 2
- States / cities
- Boston, Massachusetts • Rutland, Vermont
- Conditions
- Opiate Overdose, Opioid-Related Disorders, Narcotic-Related Disorders, Substance-related Disorders, Chemically-Induced Disorders, Mental Disorders
- Interventions
- Machine Learning-Based Clinical Decision Support: Overdose Prevention Alert (OPA) Intervention
- Behavioral
- Lead sponsor
- University of Pittsburgh
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 674 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2026
- U.S. locations
- 1
- States / cities
- Gainesville, Florida
- Conditions
- Depression, Anxiety, Opioid-Related Disorders, Pain, Chronic
- Interventions
- More Individualized Care: Assessment and Recovery through Engagement (MI-CARE)
- Behavioral
- Lead sponsor
- Kaiser Permanente
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 805 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2026
- U.S. locations
- 2
- States / cities
- Indianapolis, Indiana • Seattle, Washington
- Conditions
- Opioid Use Disorder
- Interventions
- Computerized Anxiety Sensitivity Treatment
- Behavioral
- Lead sponsor
- Southeast Louisiana Veterans Health Care System
- Federal
- Eligibility
- 18 Years and older
- Enrollment
- 32 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2019 – 2020
- U.S. locations
- 1
- States / cities
- New Orleans, Louisiana
- Conditions
- Opioid Abuse
- Interventions
- Overdose Notification
- Behavioral
- Lead sponsor
- University of Southern California
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 61 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2024
- U.S. locations
- 1
- States / cities
- Chicago, Illinois
- Conditions
- Opioid Use Disorder
- Interventions
- Ketamine, Mindfulness-Oriented Recovery Enhancement (MORE), Support Group
- Drug · Behavioral
- Lead sponsor
- University of California, San Diego
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 88 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2028
- U.S. locations
- 2
- States / cities
- La Jolla, California • Salt Lake City, Utah
- Conditions
- Substance-Related Disorders, Opioid Medication Assisted Treatment, Opioid Use Disorder, Opioid Use, Opioid Addiction, Treatment Adherence, Retention in Care
- Interventions
- Peer-Delivered Behavioral Activation ("Peer Activate")
- Behavioral
- Lead sponsor
- University of Maryland, College Park
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 200 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2025
- U.S. locations
- 2
- States / cities
- Baltimore, Maryland • College Park, Maryland
- Conditions
- Opioid-Related Disorders
- Interventions
- Behavioral: the OPT-IN Intervention
- Behavioral
- Lead sponsor
- University of Michigan
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 92 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2020
- U.S. locations
- 1
- States / cities
- Ann Arbor, Michigan
- Conditions
- Opioid-Related Disorders, Substance-Related Disorders
- Interventions
- Clonidine
- Drug
- Lead sponsor
- Yale University
- Other
- Eligibility
- 18 Years and older
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 1994 – 1999
- U.S. locations
- 1
- States / cities
- New Haven, Connecticut
- Conditions
- Cocaine-Related Disorders, Opioid-Related Disorders, Substance-Related Disorders
- Interventions
- Buprenorphine
- Drug
- Lead sponsor
- Yale University
- Other
- Eligibility
- Not listed
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- Ends 2005
- U.S. locations
- 1
- States / cities
- New Haven, Connecticut
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Lymphoproliferative Disorder, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Pain, Precancerous Condition, Unspecified Adult Solid Tumor, Protocol Specific
- Interventions
- educational intervention, Titrated pain management, questionnaire administration
- Other
- Lead sponsor
- Vanderbilt-Ingram Cancer Center
- Other
- Eligibility
- 21 Years and older
- Enrollment
- 98 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2005 – 2010
- U.S. locations
- 11
- States / cities
- Hopkinsville, Kentucky • Owensboro, Kentucky • Chattanooga, Tennessee + 4 more