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ClinicalTrials.gov public records Last synced Oct 25, 2026, 1:27 PM EDT

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Showing 25–48 of 119 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Optimization Testing Clear all
Completed Phase 3 Interventional Results available

Dose-optimization in Adolescents Aged 13-17 Diagnosed With Attention-deficit/Hyperactivity Disorder (ADHD) Using Extended-release Guanfacine HCl

NCT01081132
View directory record Official record
Conditions
Attention-Deficit/Hyperactivity Disorder
Interventions
Extended-release Guanfacine Hydrochloride, Placebo
Drug · Other
Lead sponsor
Shire
Industry
Eligibility
13 Years to 17 Years
Enrollment
314 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
54
States / cities
Dothan, Alabama • Little Rock, Arkansas • Rolling Hills Estates, California + 49 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2021 · Synced Oct 25, 2026, 1:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility of a Mind-Body Intervention for Optimism

NCT07862478
View directory record Official record
Conditions
Emotional Well-being, Psychological Stress, Cardiovascular Risk
Interventions
Emotional Well-Being Writing, Chair-Assisted Squats, Slow-Paced Breathing
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
40 Years to 65 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 25, 2026, 1:27 PM EDT
Recruiting Not applicable Interventional

Testing a Mammography Decision Intervention in a Rural Setting

NCT06522568
View directory record Official record
Conditions
Breast Cancer
Interventions
MyMammogram, Provider communication
Behavioral · Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
39 Years to 49 Years · Female only
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
3
States / cities
Keene, New Hampshire • New London, New Hampshire • Newport, New Hampshire
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 25, 2026, 1:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Community-engaged Optimization of COVID-19 Rapid Evaluation And TEsting Experiences

NCT05894655
View directory record Official record
Conditions
COVID-19, COVID-19 Pandemic
Interventions
COVID-19 walk-up, on-site testing strategy, Community Health Worker (CHW) leading testing navigation and general preventive care reminders, No-cost self-testing kit vending machines
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
Not listed
Enrollment
6,527 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Ysidro, California
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Oct 25, 2026, 1:27 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury

NCT03602014
View directory record Official record
Conditions
Hypotension, Orthostatic, Hypotension, Spinal Cord Injuries
Interventions
Northera, Placebo
Drug · Other
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 89 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 7, 2025 · Synced Oct 25, 2026, 1:27 PM EDT
Recruiting Phase 1Phase 2 Interventional

ADG126 in Combination With Pembrolizumab in Patients With Advanced/Metastatic Solid Tumors

NCT05405595
View directory record Official record
Conditions
Advanced/Metastatic Solid Tumors
Interventions
ADG126, Pembrolizumab (KEYTRUDA®), Standard of Care (Trifluridine/Tipiracil-Bevacizumab), Standard of care (Fruquintinib)
Drug
Lead sponsor
Adagene Inc
Industry
Eligibility
18 Years and older
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
7
States / cities
Scottsdale, Arizona • Duarte, California • Irvine, California + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 25, 2026, 1:27 PM EDT
Terminated No phase listed Observational

4D Cone Beam CT Reconstruction for Radiotherapy Via Motion Vector Optimization

NCT03551405
View directory record Official record
Conditions
Lung Cancer
Interventions
CBCT scan
Radiation
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 99 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 20, 2020 · Synced Oct 25, 2026, 1:27 PM EDT
Active, not recruiting Phase 1Phase 2 Interventional

A Study of Anvumetostat in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)

NCT05094336
View directory record Official record
Conditions
Advanced MTAP-null Solid Tumors
Interventions
Anvumetostat, Docetaxel, Comparator Anvumetostat Test Tablet
Drug
Lead sponsor
Amgen
Industry
Eligibility
18 Years to 100 Years
Enrollment
329 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
30
States / cities
Duarte, California • Glendale, California • Oxnard, California + 24 more
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 25, 2026, 1:27 PM EDT
Completed No phase listed Observational

Objective Brain Function Assessment of mTBI/Concussion in High School Athletes

NCT02661633
View directory record Official record
Conditions
Brain Injuries, Traumatic, Concussion, Brain, Concussion, Mild, Concussion, Intermediate, Concussion, Severe
Interventions
BrainScope Ahead 200iD, Advanced MRI Neuroimaging
Device
Lead sponsor
BrainScope Company, Inc.
Industry
Eligibility
13 Years to 19 Years
Enrollment
177 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
4
States / cities
Fayetteville, Arkansas • Bethesda, Maryland • East Lansing, Michigan + 1 more
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Oct 25, 2026, 1:27 PM EDT
Active, not recruiting No phase listed Observational

Biomarkers in the Brain Oxygen Optimization in Severe Traumatic Brain Injury Trial

NCT04565119
View directory record Official record
Conditions
TBI (Traumatic Brain Injury)
Interventions
No intervention. This is an observational study.
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
2
States / cities
Ann Arbor, Michigan • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 25, 2026, 1:27 PM EDT
Recruiting Phase 1Phase 2 Interventional

A Treatment for a Form of Age-Related Central Auditory Processing Disorder Consisting of Clemastine Fumarate Plus Engineered Sound

NCT07304024
View directory record Official record
Conditions
Central Auditory Processing Disorder, Hearing Impaired (Partially), Hearing, Hearing Abnormality, Hearing Disability, Hearing Disorder, Hearing Disorders, Hearing Impairment, Sensorineural, Hearing Handicap, Hearing Impaired, Hearing Impairment, Hearing Loss, Central Auditory Disease, Noise Exposure, Noise Induced Hearing Loss, Noise-Induced Hearing Loss, Sound Perception, Myelin Degeneration, Myelinopathy, Myelin Integrity, Remyelination, Hidden Hearing Loss, Cocktail Party Skill, Cocktail Party Syndrome, CAPD, Age Problem
Interventions
Clemastine Fumarate Combined With Engineered Sound, Clemastine Fumarate Combined With Pink Noise, Placebo Drug With Engineered Sound, Placebo - Placebo
Combination Product · Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
45 Years to 65 Years
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Oct 25, 2026, 1:27 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Pharmacokinetics of MB-102 and Use of the Non-invasive Optical Renal Function Monitor (ORFM) Device in Subjects With Normal and Impaired Renal Function and a Range of Skin Color Types

NCT02772276
View directory record Official record
Conditions
Acute Kidney Injury
Interventions
MB-102-- single dose of 4 µmol/kg, MB-102-- single dose of 130 mg, MB-102-single dose of 130 mg or 2 doses of 130 mg 12 hours apart, MB-102-- two doses of 130 mg 24 hours apart, Iohexol, QuantumLeap, Radiance, Brilliance (1 or 2 sensors), Brilliance (2-part sensor)
Drug · Device
Lead sponsor
MediBeacon
Industry
Eligibility
18 Years and older
Enrollment
234 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
3
States / cities
Edgewater, Florida • Orlando, Florida • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 26, 2023 · Synced Oct 25, 2026, 1:27 PM EDT
Recruiting Phase 1Phase 2 Interventional

A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

NCT07070232
View directory record Official record
Conditions
Advanced Solid Tumor
Interventions
BNT326, Pumitamig, Itraconazole, Paroxetine
Drug
Lead sponsor
BioNTech SE
Industry
Eligibility
18 Years and older
Enrollment
1,438 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
19
States / cities
Phoenix, Arizona • San Francisco, California • Hartford, Connecticut + 15 more
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 25, 2026, 1:27 PM EDT
Active, not recruiting Phase 2 Interventional

Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread

NCT03547973
View directory record Official record
Conditions
Metastatic Urothelial Cancer
Interventions
Sacituzumab Govitecan-hziy, Pembrolizumab, Cisplatin, Avelumab, Zimberelimab, Carboplatin, Gemcitabine, Domvanalimab, Enfortumab Vedotin
Drug
Lead sponsor
Gilead Sciences
Industry
Eligibility
18 Years and older
Enrollment
502 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2030
U.S. locations
30
States / cities
Tucson, Arizona • San Francisco, California • Littleton, Colorado + 25 more
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 25, 2026, 1:27 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

HIV Prevention and PrEP Intervention for SGM Adolescents and Parents: "Hey, Friend"

NCT04846946
View directory record Official record
Conditions
HIV Infections
Interventions
Hey, Friend
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
14 Years to 18 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 2, 2022 · Synced Oct 25, 2026, 1:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Engineering an Online STI Prevention Program: RCT

NCT04095065
View directory record Official record
Conditions
Alcohol Consumption, Sexually Transmitted Diseases
Interventions
itMatters, itMatters and itMatters Sexual Violence Prevention, itMatters Well-being and itMatters Sexual Violence Prevention, itMatters Well-being
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
18 Years to 30 Years
Enrollment
3,098 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
4
States / cities
Fresno, California • Greensboro, North Carolina • Fargo, North Dakota + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Oct 25, 2026, 1:27 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Bottle Optimization Testing Tiny Little Eaters Study

NCT07665983
View directory record Official record
Conditions
Childhood Obesity
Interventions
Feeding
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
4 Months and older
Enrollment
440 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 25, 2026, 1:27 PM EDT
Recruiting Phase 1Phase 2 Interventional

A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment Pumitamig (BNT327) and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer

NCT07079631
View directory record Official record
Conditions
Metastatic Colorectal Cancer
Interventions
BNT314, Pumitamig, SoC chemotherapy treatment 1, SoC chemotherapy treatment 2, Bevacizumab
Biological · Drug
Lead sponsor
BioNTech SE
Industry
Eligibility
18 Years and older
Enrollment
482 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
4
States / cities
New Haven, Connecticut • Grand Rapids, Michigan • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 25, 2026, 1:27 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

The PROTECT (PrEP Optimization Through Telehealth Care and Treatment) Trial

NCT06845774
View directory record Official record
Conditions
HIV Prevention
Interventions
CDC PrEP with active referral, TelePrEP
Behavioral
Lead sponsor
Hilary L Surratt, PhD
Other
Eligibility
18 Years to 99 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated May 15, 2026 · Synced Oct 25, 2026, 1:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The WORLD (Weight Optimization: Revamping Lifestyles Using the Dietary Guidelines) Study - Developing, Implementing, and Testing an Education Program

NCT00847574
View directory record Official record
Conditions
Obesity, Cardiovascular Disease
Interventions
Moderate-fat, Lower-fat
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
21 Years to 50 Years · Female only
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 18, 2023 · Synced Oct 25, 2026, 1:27 PM EDT
Completed Not applicable Interventional

Fitness for Brain Optimization for Late-Life Depression

NCT04670510
View directory record Official record
Conditions
Depression in Old Age
Interventions
On-site AE, At-home AE, Social Engagement (SE)
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
60 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 28, 2025 · Synced Oct 25, 2026, 1:27 PM EDT
Completed No phase listed Observational

Objective Brain Function Assessment of mTBI/Concussion in College Athletes

NCT02477943
View directory record Official record
Conditions
Brain Injuries, Traumatic, Concussion, Mild, Concussion, Brain, Concussion, Intermediate, Concussion, Severe
Interventions
BrainScope Ahead 200iD, Advanced MRI Neuroimaging
Device
Lead sponsor
BrainScope Company, Inc.
Industry
Eligibility
18 Years to 25 Years
Enrollment
520 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
11
States / cities
Fayetteville, Arkansas • Storrs, Connecticut • Tampa, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Oct 25, 2026, 1:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Optimization of a New Adaptive Intervention to Increase COVID-19 Testing

NCT04757298
View directory record Official record
Conditions
COVID-19 Testing
Interventions
Navigation Services, Critical Dialogue, Brief Counseling, Referral and Digital Brochure
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years and older
Enrollment
668 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 15, 2024 · Synced Oct 25, 2026, 1:27 PM EDT
Completed Not applicable Interventional

Genomic Opioid Optimization of Dosing and Selections (GOODS) Study

NCT03579121
View directory record Official record
Conditions
Perioperative/Postoperative Complications
Interventions
Pharmacogenomic (PGx), Review results
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Oct 25, 2026, 1:27 PM EDT