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ClinicalTrials.gov public records Last synced Oct 25, 2026, 2:25 PM EDT

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Showing 49–72 of 119 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Optimization Testing Clear all
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Biomarker-Led Optimization of Successful Surgical Outcomes in Moyamoya

NCT06634004
View directory record Official record
Conditions
Moyamoya Disease
Interventions
BOLD MRI
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 69 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2030
U.S. locations
2
States / cities
Baltimore, Maryland • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 25, 2026, 2:25 PM EDT
Completed Phase 2 Interventional Results available

Regimen Optimization Study

NCT02137239
View directory record Official record
Conditions
Kidney Transplantation
Interventions
Thymoglobulin, Belatacept, mycophenolate mofetil(MMF), Corticosteroids, Everolimus(EVL), Tacrolimus(TAC)
Drug
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
18 Years to 75 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
17
States / cities
San Diego, California • San Francisco, California • Aurora, Colorado + 14 more
Source: ClinicalTrials.gov public record
Updated Jun 22, 2021 · Synced Oct 25, 2026, 2:25 PM EDT
Recruiting Phase 1Phase 2 Interventional

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

NCT06324357
View directory record Official record
Conditions
Metastatic Breast Cancer, Metastatic Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Esophageal Adenocarcinoma, Colorectal Cancer
Interventions
Zongertinib, Trastuzumab deruxtecan, Trastuzumab emtansine, Trastuzumab, Capecitabine, mFOLFOX6, zanidatamab
Drug
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
18 Years and older
Enrollment
768 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
26
States / cities
Cerritos, California • Los Angeles, California • Orange, California + 18 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 25, 2026, 2:25 PM EDT
Recruiting Phase 1 Interventional

PQ203 in Advanced Malignant Tumors Including Triple Negative Breast Cancer

NCT07190469
View directory record Official record
Conditions
Triple Negative Breast Cancer (TNBC), Advanced Solid Tumors Cancer
Interventions
PQ203
Drug
Lead sponsor
ProteinQure Inc.
Industry
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
3
States / cities
Houston, Texas • San Antonio, Texas • West Valley City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Oct 25, 2026, 2:25 PM EDT
Not yet recruiting Not applicable Interventional

PROPER-GERD: A Prospective Crossover Study to Evaluate Probe Placement Optimization for Reflux Testing in Women and Lower-BMI Patients

NCT07716592
View directory record Official record
Conditions
GERD
Interventions
Bravo pH monitoring sessions
Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 90 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 25, 2026, 2:25 PM EDT
Not listed Not applicable Interventional

Development and Validation of Advanced MRI Methods for Clinical Applications

NCT03264300
View directory record Official record
Conditions
Brain Tumor
Interventions
MRI
Other
Lead sponsor
St. Joseph's Hospital and Medical Center, Phoenix
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 21, 2021 · Synced Oct 25, 2026, 2:25 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Vancomycin Dose Optimization in Obesity

NCT06601257
View directory record Official record
Conditions
Pharmacokinetics and Pharmacodynamics
Interventions
Vancomycin (IV)
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 50 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 25, 2026, 2:25 PM EDT
Recruiting Phase 1Phase 2 Interventional

A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)

NCT07111520
View directory record Official record
Conditions
Non-small Cell Lung Cancer
Interventions
BNT326, Pumitamig
Drug
Lead sponsor
BioNTech SE
Industry
Eligibility
18 Years and older
Enrollment
880 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
11
States / cities
Los Angeles, California • Stanford, California • New Haven, Connecticut + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 22, 2026 · Synced Oct 25, 2026, 2:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

COVID-19 Treatment Cascade Optimization Study

NCT05305443
View directory record Official record
Conditions
COVID-19
Interventions
Navigation Services, Brief Counseling, Critical Dialogue, Referral and Digital Brochure
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years and older
Enrollment
554 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
East Saint Louis, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 26, 2024 · Synced Oct 25, 2026, 2:25 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Taste Properties of Atazanavir and Cobicistat

NCT02307656
View directory record Official record
Conditions
HIV in Adults
Interventions
Atazanavir, Cobicistat, Active Pharmaceutical Ingredient
Drug
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2021
U.S. locations
1
States / cities
Woburn, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 5, 2022 · Synced Oct 25, 2026, 2:25 PM EDT
Recruiting Phase 1Phase 2 Interventional

FIH Trial of VERT-002 in Patients With Locally Advanced or Metastatic Solid Tumors With MET Alterations

NCT06669117
View directory record Official record
Conditions
Solid Tumor, MET Alteration
Interventions
VERT-002
Drug
Lead sponsor
Pierre Fabre Medicament
Industry
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2032
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Canton, Ohio • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Oct 25, 2026, 2:25 PM EDT
Completed No phase listed Observational

ARV Concentrations in Hair

NCT02768779
View directory record Official record
Conditions
HIV
Interventions
Hair analysis
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 13, 2018 · Synced Oct 25, 2026, 2:25 PM EDT
Completed No phase listed Observational

Novel Lung Imaging in Adults Undergoing Radiation Therapy to Assess for Radiation Pneumonitis

NCT02735746
View directory record Official record
Conditions
Lung Cancer, Breast Cancer, Mediastinum Lesion, Radiation Pneumonitis
Interventions
4D Computed Tomography (CT), Cone Beam CT, Low-dose Cinefluorography, Pulmonary Function Tests
Radiation · Device
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 22, 2025 · Synced Oct 25, 2026, 2:25 PM EDT
Completed Phase 1 Interventional Results available

Reoxygenation After Cardiac Arrest II (REOX II Study)

NCT02698826
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Protocol for rapid FiO2 optimization
Other
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
5
States / cities
Indianapolis, Indiana • Boston, Massachusetts • Jackson, Mississippi + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 29, 2022 · Synced Oct 25, 2026, 2:25 PM EDT
Terminated Phase 4 Interventional Results available

Risk Factor Control Before Orthopedic Surgery

NCT01837069
View directory record Official record
Conditions
Osteoarthritis, Cardiovascular Disease
Interventions
Metoprolol, Lisinopril, Atorvastatin, Lifestyle counseling
Drug · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years and older
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 27, 2020 · Synced Oct 25, 2026, 2:25 PM EDT
Completed Phase 4 Interventional Results available

The Effects of Vyvanse(TM) on Brain Hemodynamics and Reading

NCT00733356
View directory record Official record
Conditions
Attention Deficit/Hyperactivity Disorder
Interventions
Vyvanse
Drug
Lead sponsor
Kimberley Lakes
Other
Eligibility
6 Years to 12 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Feb 14, 2018 · Synced Oct 25, 2026, 2:25 PM EDT
Completed Not applicable Interventional Results available

AT GOAL: Adopting Technology for Glucose Optimization and Lifestyle in Pregnancy

NCT05370612
View directory record Official record
Conditions
Type2Diabetes, Pregnancy in Diabetic
Interventions
Dexcom G6 CGM, Participant Finger Stick Glucose Monitoring
Device · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 25, 2026, 2:25 PM EDT
Completed Not applicable Interventional Results available

Stroke and CPAP Outcome Study 3

NCT06029959
View directory record Official record
Conditions
Ischemic Stroke, Intra Cerebral Hemorrhage, Obstructive Sleep Apnea, Adherence, Treatment, Motivation
Interventions
Continuous positive airway pressure (CPAP), CPAP technical support intervention, Motivational Enhancement Therapy (MET), Mobile Health intervention
Device · Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Oct 25, 2026, 2:25 PM EDT
Withdrawn Not applicable Interventional

Technology Knowledge Optimization in Type 1 Diabetes (TeKnO T1D): Parents

NCT05300022
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
TeKnO T1D: Parents
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
8 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Oct 25, 2026, 2:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Engineering an Online STI Prevention Program

NCT02897804
View directory record Official record
Conditions
Sexual Behavior, Alcohol Consumption, Sexually Transmitted Diseases
Interventions
Knowledge alone, Self-efficacy alone, Perceived benefits alone, Perceived benefits and self-efficacy, Injunctive norms, Injunctive norms and self-efficacy, Injunctive norms and perceived benefits, Injunctive norms, perceived benefits, and self-efficacy, Descriptive norms alone, Descriptive norms and self-efficacy, Descriptive norms and perceived benefits, Descriptive norms,perceived benefits,self-efficacy, Descriptive and injunctive norms, Descriptive norms, injunctive norms,self-efficacy, Descriptive and injunctive norms, benefits, Descriptive and injunctive norms, benefits,efficacy, Expectancies alone, Expectancies and self-efficacy, Expectancies and Perceived Benefits, Expectancies, perceived benefits, self-efficacy, Expectancies and injunctive norms, Expectancies, injunctive norms, and self-efficacy, Expectancies, injunctive norms, benefits, Expectancies, injunctive norms, benefits, efficacy, Expectancies and descriptive norms, Expectancies, descriptive norms, and self-efficacy, Expectancies, descriptive norms, and benefits, Expectancies,descriptive norms, benefits, efficacy, Expectancies, descriptive and injunctive norms, Expectancies, descr& injun norms, efficacy, Expectancies, desc & injun norms, benefits, Expectancies,desc & injun norms,benefits,efficacy
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
18 Years to 30 Years
Enrollment
3,997 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
4
States / cities
Fresno, California • Carbondale, Illinois • Greensboro, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 9, 2019 · Synced Oct 25, 2026, 2:25 PM EDT
Terminated Not applicable Interventional Results available

Biventricular Pacing After Cardiopulmonary Bypass

NCT00498940
View directory record Official record
Conditions
Heart Failure
Interventions
Optimization Testing, Temporary Biventricular Pacing
Device
Lead sponsor
Henry M. Spotnitz
Other
Eligibility
18 Years and older
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Oct 25, 2026, 2:25 PM EDT
Completed Not applicable Interventional

Pre-emptive Prevention for Patients at High Risk for Hospital-onset Clostridioides Difficile

NCT05389904
View directory record Official record
Conditions
C. Difficile
Interventions
Arm 1: Routine care, Arm 2: Preemptive C. difficile infection prevention bundle
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
261 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 25, 2026, 2:25 PM EDT
Recruiting Not applicable Interventional

Evaluating a Our Practice Advisory (OPA) to Optimize Hemoglobin A1c (A1c) and Thyroid-Stimulating Hormone (TSH) Test Orders

NCT06993805
View directory record Official record
Conditions
Physician Workflow, Resource Utilization
Interventions
OPA
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
Not listed
Enrollment
384 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Oct 25, 2026, 2:25 PM EDT
Recruiting Not applicable Interventional

Factorial Optimization Trial to Test Cognitive Behavioral Therapy Components for Multiple Sclerosis Fatigue

NCT06809192
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
4-session Relaxation Training, 4-session Behavioral Activation, 4-session Cognitive Therapy
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Oct 25, 2026, 2:25 PM EDT