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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:31 AM EST

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Showing 1–24 of 100 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Oral Probiotics Clear all

Conditions: Type1diabetes, Type1 Diabetes Mellitus
Interventions: VSL#3; Dietary Supplement
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 5 Years to 17 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Low-grade Oral Dysplasia
Interventions: Probiotic oral lozenges, Standard of care for oral dysplasia; Biological · Other
Lead sponsor: Boston Medical Center; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pregnancy Related
Interventions: Probiotic, Placebo; Dietary Supplement
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older · Female only
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 3
States / cities: La Jolla, California • San Diego, California

Conditions: Urinary Tract Infections
Interventions: E. coli Nissle 1917; Drug
Lead sponsor: Elizabeth Lucas; Other
Eligibility: 21 Years and older
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Clostridium Difficile Infection Recurrence
Interventions: Bacillus velezensis DSM 33864, Placebo; Dietary Supplement
Lead sponsor: Novozymes A/S; Industry
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Royal Oak, Michigan

Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: Culturelle (Lactobacillus rhamnosus strain GG), Placebo; Dietary Supplement · Other
Lead sponsor: Northwell Health; Other
Eligibility: 5 Years to 18 Years
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: New Hyde Park, New York

Conditions: Type 1 Diabetes, type1diabetes, Type 1 Diabetes Mellitus
Interventions: Lactiplantibacillus plantarum, Placebo; Dietary Supplement · Other
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 3 Years to 45 Years
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Major Abdominal Operation
Interventions: VSL #3 BID; Dietary Supplement
Lead sponsor: Catholic Health Initiatives; Other
Eligibility: 18 Years to 99 Years
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Des Moines, Iowa

Conditions: Acne Vulgaris, Acneiform Eruptions, Skin Diseases, Sebaceous Gland Diseases
Interventions: Probiotic, Oral herbal powder supplement; Other · Dietary Supplement
Lead sponsor: Integrative Skin Science and Research; Industry
Eligibility: 12 Years to 45 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Asthma
Interventions: Seeking Health Probiota Bifido; Dietary Supplement
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 99 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Adults on Antibiotics
Interventions: Bifidobacterium animalis subsp. lactis strain BB-12, Placebo; Drug
Lead sponsor: Georgetown University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Dysphagia
Interventions: VSL#3; Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 65 Years to 99 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Clostridium Difficile
Interventions: Probiotic, Placebo; Dietary Supplement
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Non Small Cell Lung Cancer (NSCLC)
Interventions: Dacomitinib, Doxycycline, Probiotic, Alclometasone cream; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years and older
Enrollment: 236 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 79
States / cities: Duarte, California • Fullerton, California • Irvine, California + 49 more

Conditions: Vaginal Personal Care
Interventions: VM-02, Commercial Oral Probiotic Competitor, VM-02 Placebo; Other · Dietary Supplement
Lead sponsor: Seed Health; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 70 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Venice, California

Conditions: Lactose Intolerance
Interventions: Lactobacillus acidophilus MPH734, Placebo; Dietary Supplement
Lead sponsor: Lemuel W. Taylor IV; Other
Eligibility: 18 Years to 55 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Belton, Texas

Conditions: Atopic Dermatitis
Interventions: Oral Probiotics; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 6 Months to 3 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Infection, Pregnancy
Interventions: Placebo, Probiotic dietary supplement; Drug · Dietary Supplement
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 55 Years · Female only
Enrollment: 251 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2017
U.S. locations: 3
States / cities: Aptos, California • Santa Cruz, California • Stanford, California

Conditions: Vaginal Dysbiosis, Vaginal Disease, Molecular-bacterial Vaginosis
Interventions: Probiotic Group, Placebo Group; Dietary Supplement
Lead sponsor: Columbia University; Other
Eligibility: 18 Years to 45 Years · Male only
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Human Microbiome
Interventions: Probiotic; Dietary Supplement
Lead sponsor: Integrative Skin Science and Research; Industry
Eligibility: 40 Years and older
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Stress Physiology
Interventions: Probiotic, Prebiotic, Placebo; Dietary Supplement · Other
Lead sponsor: United States Army Research Institute of Environmental Medicine; Federal
Eligibility: 17 Years to 39 Years
Enrollment: 73 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Natick, Massachusetts

Conditions: Oral Microbiome
Interventions: Placebo-Control Supplement, Streptococcus-Containing Probiotic Supplement; Dietary Supplement
Lead sponsor: University of California, Davis; Other
Eligibility: 21 Years to 45 Years
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Davis, California

Conditions: Vancomycin Resistant Enterococcal Colonization
Interventions: Lactobacillus GG or Culturelle; Biological
Lead sponsor: Tufts Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2012
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Obesity
Interventions: Lactobacillus Rhamnosus GG, Placebo; Dietary Supplement
Lead sponsor: Tufts Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Boston, Massachusetts

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Modulation of Type 1 Diabetes Susceptibility Through the Use of Probiotics

Lactobacillus Lozenges as Preventative Care in Low-grade Dysplasia

Correlating Probiotic Dietary Supplements During Pregnancy With Maternal Microbiome Profiles

Open Label Trial of Nissle 1917

Bacillus Velezensis DSM 33864 for Reduction of the Risk of Recurrent Clostridioides Difficile Infections

Role of Probiotics in Treatment of Pediatric NAFLD Patients by Assessing With Fibroscan

Reducing Innate Inflammation in New Onset Type 1 Diabetes

Probiotics and Recovery From Surgery

The Effects of Oral Probiotics and Herbal Supplementation on the Gut Microbiome and Sebum Excretion Rate in Non-Cystic Acne

Oral Probiotic Administration to Modulate the Airway Microbiome in Obese Asthmatic Subjects

Safety of BB-12 Supplemented Strawberry Yogurt For Healthy Adults on Antibiotics

Impact of Probiotics on Oral Microbiota in Older Adults With Dysphagia

Probiotics for Clostridium Difficile Infection in Older Adults

Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO

Randomized, Double-blind, Placebo-controlled Trial Investigating the Role of a Personal Care Product on Vaginal Health

Does Daily Supplementation of Lactobacillus Acidophilus MPH734, for One Week, Affect Acute (Immediate), Subacute (7 Days), and Post-treatment Discontinuation Lactose Metabolism, Gastrointestinal Symptoms, and Clinical Markers of Inflammation and Safety Compared to a Placebo

The Effects of Probiotics in Atopic Dermatitis

Effects of Oral Probiotic Supplementation on Group B Strep (GBS) Rectovaginal Colonization in Pregnancy

Feasibility of an Oral Intervention for Sexual Health in Transgender Men

Oral Probiotics on the Shift in Gut Microbiome and Skin Carotenoid Levels

Prebiotic and Probiotic Modulation of the Gut Microbiota-gut-brain Axis During Acute Stress

The Probiotic for Oral Health (PRO Health) Study

Probiotic Lactobacillus GG to Eliminate VRE Colonization

Does Weight Loss Surgery and Probiotic Supplementation Lead to a "Lean" Gut Microbiota?