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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Oral Probiotics Clear all
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Clinical Study to Assess the Effects of Prebiotic and Probiotic Supplement

NCT06794619
View directory record Official record
Conditions
Healthy
Interventions
Placebo, Dietary Supplement with actives
Dietary Supplement
Lead sponsor
Olly, PBC
Industry
Eligibility
18 Years to 50 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Phase 1 Interventional

Probiotics and Oxytocin Nasal Spray on Social Behaviors of Autism Spectrum Disorder (ASD) Children

NCT03337035
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
intranasal oxytocin, oral probiotics, oral placebo
Drug · Dietary Supplement
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
3 Years to 25 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Sep 25, 2026, 10:56 PM EDT
Terminated Phase 2 Interventional Results available

Effect of VSL#3 on Bone Mineral Density in Postmenopausal Women

NCT03165747
View directory record Official record
Conditions
Menopausal Osteoporosis
Interventions
VSL#3, Placebo
Drug · Other
Lead sponsor
Emory University
Other
Eligibility
50 Years to 65 Years · Female only
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Oral Probiotic Supplementation on Group B Strep (GBS) Rectovaginal Colonization in Pregnancy

NCT01479478
View directory record Official record
Conditions
Infection, Pregnancy
Interventions
Placebo, Probiotic dietary supplement
Drug · Dietary Supplement
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
3
States / cities
Aptos, California • Santa Cruz, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2018 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional Results available

Double-Blind Trial of a Probiotic Supplement to Reduce the Symptoms of Schizophrenia

NCT01242371
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
Probiotic Supplement, Identical-appearing Placebo
Dietary Supplement
Lead sponsor
Sheppard Pratt Health System
Other
Eligibility
18 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Towson, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 4, 2019 · Synced Sep 25, 2026, 10:56 PM EDT
Recruiting Early Phase 1 Interventional

Probiotic Administration for Adolescent Depression

NCT06898788
View directory record Official record
Conditions
Depression
Interventions
Visbiome, Placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
15 Years to 24 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

iVS-1 Probiotic Intervention Targeting Biological Aging in Midlife Adults

NCT07407894
View directory record Official record
Conditions
Healthy Aging, Anti Aging
Interventions
Bifidobacterium adolescentis iVS-1, Placebo
Dietary Supplement
Lead sponsor
Synbiotic Health
Industry
Eligibility
40 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Port Richey, Florida
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigation of the Ability of a Supplement to Increase Good Bacteria in the Human Intestine and Blood Sugar Levels

NCT01944904
View directory record Official record
Conditions
Pre-diabetic
Interventions
Sugar Pill, XOS 2.8
Dietary Supplement
Lead sponsor
University of California, Los Angeles
Other
Eligibility
20 Years to 70 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Phase 2 Interventional Results available

Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO

NCT01465802
View directory record Official record
Conditions
Non Small Cell Lung Cancer (NSCLC)
Interventions
Dacomitinib, Doxycycline, Probiotic, Alclometasone cream
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
79
States / cities
Duarte, California • Fullerton, California • Irvine, California + 49 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2019 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics

NCT03755765
View directory record Official record
Conditions
Antibiotic-associated Diarrhea
Interventions
Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, BB-12, Control
Drug · Biological · Other
Lead sponsor
Georgetown University
Other
Eligibility
18 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 16, 2023 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of a Probiotic Water on Oral Health in Adults

NCT04473404
View directory record Official record
Conditions
Oral Bacteria, Halitosis
Interventions
Streptococcus salivarius DB-B5 - 2 billion CFU/day, Streptococcus salivarius DB-B5 - 10 billion CFU/day, Placebo
Dietary Supplement · Other
Lead sponsor
Dose Biosystems Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 3, 2020 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Phase 3 Interventional Results available

Group B Streptococcus Response After Probiotic Exposure

NCT04721912
View directory record Official record
Conditions
Group B Strep Infection
Interventions
Probiotic dietary supplement
Drug
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional

A Study to Assess the Efficacy and Safety of Salix Probiotic Blend in Participants With Functional Gastrointestinal Disturbances

NCT04155801
View directory record Official record
Conditions
Functional Gastrointestinal Disorders
Interventions
Salix Probiotic Blend
Dietary Supplement
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
188 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Sep 25, 2026, 10:56 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Oral Probiotics on the Microbiome and Lipidome in Acne Vulgaris

NCT04596748
View directory record Official record
Conditions
Acne Vulgaris
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
Integrative Skin Science and Research
Industry
Eligibility
13 Years to 45 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional

Optimizing Overactive Bladder Treatment

NCT03904407
View directory record Official record
Conditions
Overactive Bladder
Interventions
Lactobacillus Probiotic Capsule, Matching Lactobacillus Probiotic Placebo Capsule
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older · Female only
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Hillsborough, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated May 10, 2020 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Safety of BB-12 Supplemented Strawberry Yogurt For Healthy Children

NCT01652287
View directory record Official record
Conditions
Children
Interventions
BB-12 supplemented strawberry yogurt, Strawberry flavored yogurt
Drug · Other
Lead sponsor
Georgetown University
Other
Eligibility
1 Year to 5 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 21, 2024 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional

The Effects of an Orally-Administered Probiotic on Vaginal Symptoms

NCT07829861
View directory record Official record
Conditions
Vaginal Odor
Interventions
Orally-administered probiotic, Placebo
Dietary Supplement
Lead sponsor
Bonafide Health
Industry
Eligibility
18 Years to 65 Years · Female only
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Harrison, New York
Source: ClinicalTrials.gov public record
Updated Sep 20, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional Results available

Probiotics in Infants With Gastroschisis

NCT01316510
View directory record Official record
Conditions
Gastroschisis
Interventions
Bifidobacteria infantis, Placebo
Dietary Supplement · Other
Lead sponsor
University of California, Davis
Other
Eligibility
Up to 2 Weeks
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jul 12, 2018 · Synced Sep 25, 2026, 10:56 PM EDT
Active, not recruiting Phase 2 Interventional

Reducing Innate Inflammation in New Onset Type 1 Diabetes

NCT04335656
View directory record Official record
Conditions
Type 1 Diabetes, type1diabetes, Type 1 Diabetes Mellitus
Interventions
Lactiplantibacillus plantarum, Placebo
Dietary Supplement · Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
3 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prenatal Probiotic Intervention

NCT03240419
View directory record Official record
Conditions
Childhood Obesity, Maternal Obesity During Childbirth, Insulin Resistance, Inflammation
Interventions
Probiotics, Placebo
Dietary Supplement
Lead sponsor
Arkansas Children's Hospital Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jan 17, 2022 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

INF108F in Infants With Food Protein Induced Proctocolitis

NCT05793112
View directory record Official record
Conditions
Infant Development, Gut Microbiome, Food Protein Induced Allergic Proctocolitis
Interventions
INF108F probiotic, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
1 Day to 90 Days
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Newton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Sep 25, 2026, 10:56 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Diabetic Cardiomyopathy and Heart Failure

NCT05571865
View directory record Official record
Conditions
Diabetic Cardiomyopathies, Heart Failure
Interventions
Probiotic
Dietary Supplement
Lead sponsor
University of Louisville
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Sep 25, 2026, 10:56 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Impact of Probiotics on Drug, Vitamin, and Hormone Metabolism

NCT04281407
View directory record Official record
Conditions
Metabolism
Interventions
Visbiome
Dietary Supplement
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 23, 2020 · Synced Sep 25, 2026, 10:56 PM EDT
Completed Phase 2 Interventional Results available

Probiotic Prophylaxis of Hirschprung's Disease Associated Enterocolitis (HAEC)

NCT00630838
View directory record Official record
Conditions
Hirschsprung Disease
Interventions
VSL#3, Placebo
Drug
Lead sponsor
University of Michigan
Other
Eligibility
1 Month to 12 Months
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
2
States / cities
Ann Arbor, Michigan • Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jul 18, 2016 · Synced Sep 25, 2026, 10:56 PM EDT