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ClinicalTrials.gov public records Last synced Nov 9, 2026, 11:00 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 216 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Pain control regimens Clear all

Conditions: Cesarean Section Complications
Interventions: Erector Spinae Plane (ESP) Block, bupivacaine liposome injectable suspension, bupivacaine; Procedure · Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Pain, Postoperative
Interventions: Cold therapy via reusable cold gel pack; Device
Lead sponsor: Cleveland Clinic Florida; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Weston, Florida

Conditions: Postoperative Pain, Abdominoplasty Surgery, Multimodal Analgesia
Interventions: MMA regimen, ZYNRELEF kit components for administration, HTX-011, Bupivacaine Hydrochloride; Drug · Device
Lead sponsor: Heron Therapeutics; Industry
Eligibility: 18 Years and older
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 2
States / cities: Bellaire, Texas • San Antonio, Texas

Conditions: Tonsillitis, Tonsillectomy
Interventions: Gabapentin; Drug
Lead sponsor: Children's Healthcare of Atlanta; Other
Eligibility: 3 Years to 18 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Post Operative Pain Control, Narcotic Use, Pelvic Organ Prolapse, Urinary Incontinence , Stress, Surgery
Interventions: Sprix; Drug
Lead sponsor: University of Louisville; Other
Eligibility: 18 Years and older · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: Louisville, Kentucky

Conditions: Diabetic Peripheral Neuropathic Pain
Interventions: V3381, Placebo; Drug
Lead sponsor: Vernalis (R&D) Ltd; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 161 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 9
States / cities: Little Rock, Arkansas • Ocala, Florida • St. Petersburg, Florida + 5 more

Conditions: Fecal Incontinence, Neurogenic Bowel
Interventions: Dose Response - NS and USP Glycerin - First Intervention, Effectiveness - NS and USP Glycerin - Second Intervention; Drug
Lead sponsor: Nemours Children's Clinic; Other
Eligibility: 3 Years to 12 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Other Abortion, Spontaneous Abortion
Interventions: Gabapentin, Placebo; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: IUD Insertion Pain
Interventions: Ketorolac, Placebo; Drug
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years and older · Female only
Enrollment: 108 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Hillsborough, North Carolina

Conditions: Hip Pain Chronic
Interventions: iVR Group, Standard pain management regimen; Device · Drug
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Adolescent Idiopathic Scoliosis, Respiratory Depression, Postoperative Pain
Interventions: pharmacokinetic simulation; Other
Lead sponsor: University of Florida; Other
Eligibility: 10 Years to 18 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Orthopaedic Fractures
Interventions: NSAID, Gabapentinoids, placebo; Drug
Lead sponsor: Major Extremity Trauma Research Consortium; Other
Eligibility: 18 Years to 80 Years
Enrollment: 450 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 17
States / cities: Miami, Florida • West Palm Beach, Florida • Indianapolis, Indiana + 13 more

Conditions: Analgesia
Interventions: HTX-011, Luer lock applicator, Ibuprofen, Acetaminophen; Drug · Device
Lead sponsor: Heron Therapeutics; Industry
Eligibility: 18 Years and older
Enrollment: 209 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 30
States / cities: Anaheim, California • La Mesa, California • Orange, California + 22 more

Conditions: Interstitial Cystitis
Interventions: MN-001 BID, MN-001, Placebo; Drug
Lead sponsor: MediciNova; Industry
Eligibility: 18 Years and older
Enrollment: 296 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2006
U.S. locations: 28
States / cities: Birmingham, Alabama • Glendora, California • Long Beach, California + 25 more

Conditions: Low Back Pain, Veterans Family
Interventions: Pain modulation with physical pain treatment, Telephone delivered self-management counseling for increasing physical activity, Telephone delivered behavioral treatment for participants with high risk for continued disability, Patient preference treatment protocol, Nonpharmacological guideline adherent treatment protocol, Facilitated referrals to existing VA or non-VA pain management resources; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 1,817 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8, Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
Interventions: Gabapentin, Methadone, Oxycodone, Quality-of-Life Assessment, Questionnaire Administration, Venlafaxine, Venlafaxine Hydrochloride Extended Release; Drug · Other
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 18 Years and older
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Osteoarthritis, Knee
Interventions: Vitamin D (cholecalciferol), Placebo; Dietary Supplement
Lead sponsor: Tufts Medical Center; Other
Eligibility: 45 Years to 90 Years
Enrollment: 146 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pain, Postoperative
Interventions: Methadone Hydrochloride, Standard pain regimen, Spinal Fusion Surgery, Dexamethasone, Ketamine, Remifentanil, Sufentanil; Drug · Other · Procedure
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years to 80 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Pelvic Pain, Headaches, Emotional
Interventions: loestrin 24/4 vs loestrin 1/20, loestrin 1/20; Drug
Lead sponsor: Scott and White Hospital & Clinic; Other
Eligibility: 18 Years to 48 Years · Female only
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Temple, Texas

Conditions: Opioid Consumption, Postoperative
Interventions: Suzetrigine, Standard Care (in control arm); Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Post Operative Pain
Interventions: Suzetrigine; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions: Fasinumab, Naproxen, Fasinumab-matching placebo, Naproxen-matching placebo; Drug
Lead sponsor: Regeneron Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 3,307 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 58
States / cities: Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 50 more

Conditions: Total Hip Arthroplasty
Interventions: Quadratus Lumborum Block (QLB), Standard of Care; Drug
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Pain, Postoperative
Interventions: Gabapentin, Acetaminophen, Celecoxib, Ketorolac, Paracervical block with ropivacaine, Local anesthetic injection with ropivacaine at abdominal laparoscopic port sites, Hydromorphone, Oxycodone; Drug · Procedure
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 25 Years to 90 Years · Female only
Enrollment: 68 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Williamsville, New York

Search by objective public record fields.

ESP Block for Post Cesarean Analgesia

Effect of Cold Therapy Implementation on Multi-modal Postoperative Pain Management

Cohort 2 (Abdominoplasty) of: A Multi-surgery Assessment of ZYNRELEF (HTX-011)

Gabapentin Premedication to Reduce Postoperative Pain for Pediatric Tonsillectomy

Sprix for Postoperative Pain Control Following Gynecologic Surgery

Study of the Safety, Tolerability and Efficacy of V3381 in Patients With Diabetic Peripheral Neuropathic Pain

A Within Subjects Comparison of Two Antegrade Flushing Regimens in Children

Gabapentin as an Adjunct to Perioperative Pain Management Regimens for Uterine Aspiration

Oral Ketorolac for IUD Pain Reduction

The Effectiveness of Immersive Virtual Reality as a Pain Control Modality After Hip Arthroscopy

Anesthetic Optimization in Scoliosis Surgery

Improving Pain Management and Long Term Outcomes Following High Energy Orthopedic Trauma (Pain Study)

Study of Post-Herniorrhaphy Non-opioid MMA Regimens

Phase II Study Efficacy and Safety of Two Dosing Regimens of MN-001 in Patients With Interstitial Cystitis

Improving Veteran Access to Integrated Management of Back Pain

Gabapentin, Methadone, and Oxycodone With or Without Venlafaxine Hydrochloride in Managing Pain in Participants With Stage II-IV Squamous Cell Head and Neck Cancer Undergoing Chemoradiation Therapy

Vitamin D to Slow Progression of Knee Osteoarthritis

Intraoperative Methadone Administration for Improved Pain Control in Spinal Fusion Patients

Study of Loestrin 24(24 Days of "Real" Pills) Fe Versus Loestrin 1/20 (21 "Real" Pills)

Precision Pain Management - A Randomized Clinical Trial Assessing the Efficacy of Suzetrigine on Postoperative Analgesia Among Surgical Patients at Higher Risk for Persistent Postoperative Opioid Use (POU)

A Study Of Opioid Avoidance In Surgery Through Integrating Suzetrigine

A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip

Quadratus Lumborum Block Versus Control for Total Hip Arthroplasty

Multimodal Pain Management After Robotic-Assisted Total Laparoscopic Hysterectomy