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ClinicalTrials.gov public records Last synced Oct 6, 2026, 3:57 AM EDT

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Showing 1–24 of 28 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Pain management following hernia repair Clear all
Active, not recruiting Not applicable Interventional

CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs

NCT06565546
View directory record Official record
Conditions
Ventral Hernia
Interventions
Opioid pain medication prescribed based on CYP2D6 genotype testing PLUS Acetaminophen and Gabapentin, Acetaminophen and Gabapentin: standard postoperative pain medications
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 6, 2026, 3:57 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Phase I/II Dose-escalation Study to Evaluate Safety, PK and Efficacy of TLC590 for Postsurgical Pain Management

NCT03591146
View directory record Official record
Conditions
Inguinal Hernia
Interventions
TLC590, Naropin
Drug
Lead sponsor
Taiwan Liposome Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Draper, Utah
Source: ClinicalTrials.gov public record
Updated Jul 14, 2021 · Synced Oct 6, 2026, 3:57 AM EDT
Completed No phase listed Observational

Innovative Approaches to Assessment of Pain Control and Sedation in the NICU

NCT03057782
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Waveguard (TM) EEG cap, Micro Movement Sensor, Pico Movement Sensor, QS Piezostimulator, tactileTM sensory evaluator
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
1 Hour to 6 Months
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 15, 2022 · Synced Oct 6, 2026, 3:57 AM EDT
Not listed Not applicable Interventional

Bupivicaine to Reduce Postoperative Pain in Laparoscopic Ventral Hernia Repair

NCT01530815
View directory record Official record
Conditions
Postoperative Pain
Interventions
Bupivicaine Infusion
Drug
Lead sponsor
Chang, Steve S., M.D.
Individual
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Feb 10, 2012 · Synced Oct 6, 2026, 3:57 AM EDT
Completed Not applicable Interventional Results available

Analgesic Efficacy After Umbilical Hernia Repair in Children

NCT00578136
View directory record Official record
Conditions
Umbilical Hernia
Interventions
Bupivacaine
Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
5 Years to 17 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 15, 2014 · Synced Oct 6, 2026, 3:57 AM EDT
Not listed Not applicable Interventional

Medial Versus Traditional Approach to US-guided TAP Blocks for Open Inguinal Hernia Repair

NCT01589796
View directory record Official record
Conditions
Abdominal Muscles/Ultrasonography, Adult, Ambulatory Surgical Procedures, Anesthetics, Local/Administration & Dosage, Ropivacaine/Administration & Dosage, Ropivacaine/Analogs & Derivatives, Hernia, Inguinal/Surgery, Humans, Nerve Block/Methods, Pain Measurement/Methods, Pain, Postoperative/Prevention & Control, Ultrasonography, Interventional
Interventions
TAP block
Procedure
Lead sponsor
Stamford Anesthesiology Services, PC
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
2
States / cities
Stamford, Connecticut
Source: ClinicalTrials.gov public record
Updated May 2, 2012 · Synced Oct 6, 2026, 3:57 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Impact of Quadratus Lumborum Block on Recovery Profile After Ventral Hernia Repair

NCT03794882
View directory record Official record
Conditions
Pain, Postoperative, Opioid Use
Interventions
Quadratus Lumborum Block, Standard Medical Management
Combination Product · Procedure
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 80 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Oct 6, 2026, 3:57 AM EDT
Completed Not applicable Interventional

Comparison of Two Different Pain Management Techniques in Pediatric Patients Undergoing a Hernia Repair

NCT01740193
View directory record Official record
Conditions
Pain, Inguinal Hernia
Interventions
TAP Block, Ilioinguinal/iliohypogastric blockade
Procedure
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
12 Months to 10 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 19, 2018 · Synced Oct 6, 2026, 3:57 AM EDT
Not yet recruiting Not applicable Interventional

Quadratus Lumborum Versus Placebo in Open Ventral Hernia Repair

NCT06953635
View directory record Official record
Conditions
Hernia, Ventral, Pain Management
Interventions
Quadratus Lumborum (QL) Block, Placebo
Procedure
Lead sponsor
University of Tennessee Graduate School of Medicine
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Oct 6, 2026, 3:57 AM EDT
Completed Phase 2 Interventional

A Phase 2, Randomized, Double-Blind, Dose Escalation Study in Postoperative Pain Open Inguinal Herniorrhaphy

NCT05080959
View directory record Official record
Conditions
Inguinal Herniorrhaphy
Interventions
CPL-01, Naropin 150 MG Per 20 ML Injection, Placebo
Drug
Lead sponsor
Cali Pharmaceuticals LLC
Industry
Eligibility
18 Years to 75 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
5
States / cities
Sheffield, Alabama • Phoenix, Arizona • Anaheim, California + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 20, 2022 · Synced Oct 6, 2026, 3:57 AM EDT
Not listed Phase 4 Interventional

Pain Relief After Hiatal Hernia Repair Surgery

NCT04936711
View directory record Official record
Conditions
Shoulder Pain, Hiatal Hernia
Interventions
Resteck Shiatsu Neck and Back Massager, Marcaine
Device · Drug
Lead sponsor
Norton Thoracic Institute
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 23, 2021 · Synced Oct 6, 2026, 3:57 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Analgesia in Children Using Caudal Epidural Ropivacaine

NCT01494272
View directory record Official record
Conditions
Inguinal Hernia, Circumcision
Interventions
Not listed
Lead sponsor
Loma Linda University
Other
Eligibility
2 Months to 2 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
2
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Nov 25, 2015 · Synced Oct 6, 2026, 3:57 AM EDT
Completed Not applicable Interventional

Music Therapy in the Treatment of Perioperative Anxiety and Pain

NCT05263635
View directory record Official record
Conditions
Pain, Post Operative, Anxiety, Opioid Use
Interventions
Music therapy, Standard of Care Enhanced Recovery After Surgery (ERAS)
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 4, 2024 · Synced Oct 6, 2026, 3:57 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Improving Pain Control in Paraesophageal Hernia Repair: Intravenous Lidocaine Versus Placebo

NCT04096170
View directory record Official record
Conditions
Hernia, Paraesophageal
Interventions
IV lidocaine, Placebo
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 6, 2026, 3:57 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Multimodal Pain Therapy After Hernia Repair

NCT03792295
View directory record Official record
Conditions
Hernia, Abdominal, Pain
Interventions
acetominophen, ibuprofen, oxycodone, Oxycodone
Drug
Lead sponsor
Khashayar Vaziri
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Oct 6, 2026, 3:57 AM EDT
Completed Phase 3 Interventional

Herniorrhaphy for Postoperative Pain

NCT05813847
View directory record Official record
Conditions
Hernia, Inguinal, Post Operative Pain
Interventions
local anaesthetic injection of CPL-01, Morphine (rescue medication), Acetaminophen (rescue medication), Oxycodone (rescue medication), local anaesthetic injection of placebo, local anaesthetic injection of ropivacaine HCl, Open inguinal hernia repair
Drug · Procedure
Lead sponsor
Cali Pharmaceuticals LLC
Industry
Eligibility
18 Years to 75 Years
Enrollment
518 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Oct 6, 2026, 3:57 AM EDT
Completed Phase 3 Interventional Results available

Study of Post-Herniorrhaphy Non-opioid MMA Regimens

NCT03907176
View directory record Official record
Conditions
Analgesia
Interventions
HTX-011, Luer lock applicator, Ibuprofen, Acetaminophen
Drug · Device
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
30
States / cities
Anaheim, California • La Mesa, California • Orange, California + 22 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 6, 2026, 3:57 AM EDT
Completed Phase 3 Interventional

An Open-label Safety and Pharmacokinetic Study of INL-001 in Adults Following Various Open Soft-Tissue Surgeries

NCT04785638
View directory record Official record
Conditions
Pain, Postoperative, Hernia, Ventral, Abdominoplasty, Hysterectomy, Colectomy, Reduction Mammoplasty
Interventions
INL-001 (bupivacaine hydrochloride) implant
Combination Product
Lead sponsor
Innocoll
Industry
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
8
States / cities
Florence, Alabama • Sheffield, Alabama • Pasadena, California + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 13, 2023 · Synced Oct 6, 2026, 3:57 AM EDT
Terminated Phase 2Phase 3 Interventional

Post-Operative Pain Scores and Analgesic Requirements After Elective Inguinal Herniorrhaphy

NCT00735124
View directory record Official record
Conditions
Pain, Analgesia, Hernia, Inguinal
Interventions
Gabapentin, placebo
Drug · Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 28, 2017 · Synced Oct 6, 2026, 3:57 AM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine (Exparel) for Postoperative Pain Control for Open and Laparoscopic Abdominal Hernia Repair

NCT02128646
View directory record Official record
Conditions
Pain
Interventions
EXPAREL, Ketorolac, laparoscopic abdominal hernia repair, an open surgery for abdominal hernia repair
Drug · Procedure
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Oct 6, 2026, 3:57 AM EDT
Completed Not applicable Interventional

Ultrasound-guided Rectus Sheath Block for Post-operative Pain Control Following Umbilical Hernia Repair

NCT00836134
View directory record Official record
Conditions
Pain
Interventions
rectus sheath block, local anesthetic infiltration
Procedure
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
1 Year to 17 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 12, 2014 · Synced Oct 6, 2026, 3:57 AM EDT
Completed Phase 2 Interventional Results available

Pilot Herniorrhaphy Study for Postoperative Analgesia

NCT02504580
View directory record Official record
Conditions
Postoperative Pain
Interventions
HTX-011, Placebo, HTX-002, Bupivacaine HCI (Marcaine), HTX-011A, HTX-011B, HTX-009
Drug
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
463 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
3
States / cities
Anaheim, California • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 6, 2026, 3:57 AM EDT
Completed Not applicable Interventional

Laparoscopic Ventral Hernia Repair With Elastomeric Pain Pump

NCT00472134
View directory record Official record
Conditions
Hernia, Ventral
Interventions
bupivacaine, On-Q PainBuster pump
Drug · Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 8, 2015 · Synced Oct 6, 2026, 3:57 AM EDT
Recruiting Phase 4 Interventional

Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis Release

NCT07840183
View directory record Official record
Conditions
Ventral Hernia, Ventral Hernia Repair, Postoperative Pain
Interventions
Bupivicaine, Fentanyl, Thoracic epidural analgesia, Hydromorphone, Acetaminophen, Ketorolac, magnesium sulfate, Tramadol, Gabapentin, Cyclobenzaprine, transversus abdominis plane block
Drug · Device · Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 6, 2026, 3:57 AM EDT