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Showing 1–24 of 57 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Periodontal Surgery Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers

Immediate Post-Operative Anesthesia With Either Lidocaine or Bupivacaine

NCT06293807
View directory record Official record
Conditions
Periodontal Diseases
Interventions
Xylocaine 2 % with 1:100,000 epinephrine, Bupivicaine 0.5% with 1:200,000 epinephrine, Placebo
Drug · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Sep 6, 2026, 2:52 PM EDT
Not listed Not applicable Interventional

A Comparison of Two Socket Sealing Collagen Matrices for Extraction Socket Management

NCT03003819
View directory record Official record
Conditions
Tooth Loss
Interventions
Control Collagen Wound Dressing, Test Collagen Matrix
Device
Lead sponsor
McGuire Institute
Industry
Eligibility
18 Years to 75 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Fenton, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Sep 6, 2026, 2:52 PM EDT
Completed No phase listed Observational

Microbes and Bariatric Surgery

NCT01130207
View directory record Official record
Conditions
Obesity, Diabetes, Periodontal Disease
Interventions
Not listed
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 18, 2014 · Synced Sep 6, 2026, 2:52 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

PRF + Minocycline vs Arestin in Non-surgical Perio Therapy

NCT07437209
View directory record Official record
Conditions
Non-surgical Periodontal Therapy
Interventions
Arestin, PRF + M
Drug · Biological
Lead sponsor
Center for Advanced Rejuvenation and Esthetics
Network
Eligibility
Not listed
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Sarasota, Florida
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 6, 2026, 2:52 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

The Use of Dental Pulp Tissue as an Autogenous Graft for Ridge Augmentation

NCT03943849
View directory record Official record
Conditions
Tooth Loss
Interventions
Particulate bone graft, Autogenous dental pulp tissue, Resorbable collagen membrane, Suture
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 2, 2022 · Synced Sep 6, 2026, 2:52 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effect of Disinfective Solution as an Adjunct to Maintenance Therapy of Inflamed Periodontal Pockets

NCT02316652
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
Scaling and root planing, Scaling and root planing with solution
Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
30 Years and older
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Sep 6, 2026, 2:52 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Utilization of a Videoscope in Periodontal Regeneration

NCT05275192
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
Videoscope-assisted periodontal regeneration minimally invasive surgery, Periodontal regeneration minimally invasive surgery, Guided tissue regeneration surgery
Device · Procedure
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 6, 2026, 2:52 PM EDT
Not listed Phase 4 Interventional

Evaluation of Pharmacogenomics Testing to Precision Prescriptions in Periodontal Patients

NCT05467436
View directory record Official record
Conditions
Oral Surgeries
Interventions
Local anesthetics, IV sedation drugs and analgesics.
Drug
Lead sponsor
Augusta University
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 19, 2022 · Synced Sep 6, 2026, 2:52 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Adjunctive Hydrogen Peroxide for Periodontal Therapy

NCT03262701
View directory record Official record
Conditions
Periodontitis, Chronic
Interventions
Hydrogen Peroxide Gel, 13 weeks, Hydrogen Peroxide Gel, 26 weeks, Scaling and Root planing group
Drug · Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 80 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Dec 20, 2022 · Synced Sep 6, 2026, 2:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Controlled Study Comparing REPaiR® and MIST Therapies for Treatment of Periodontitis

NCT04169139
View directory record Official record
Conditions
Periodontal Diseases
Interventions
MIST (minimally invasive surgical therapy)
Device
Lead sponsor
McGuire Institute
Industry
Eligibility
18 Years to 75 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 29, 2023 · Synced Sep 6, 2026, 2:52 PM EDT
Completed Phase 3 Interventional

Diabetes and Periodontal Therapy Trial

NCT00997178
View directory record Official record
Conditions
Chronic Periodontitis, Type 2 Diabetes
Interventions
Non-surgical periodontal therapy, Delayed non-surgical periodontal therapy
Procedure · Other
Lead sponsor
Stony Brook University
Other
Eligibility
35 Years and older
Enrollment
514 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
8
States / cities
Birmingham, Alabama • Minneapolis, Minnesota • Stony Brook, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 19, 2014 · Synced Sep 6, 2026, 2:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Utilization of a Periodontal Endoscope in Nonsurgical Periodontal Therapy

NCT05293301
View directory record Official record
Conditions
Periodontitis, Adult
Interventions
Use of Periodontal Endoscope (Perioscopy®) to enhance visualization while performing teeth deep cleaning, Use of traditional loupes to enhance magnification to enhance visualization while performing teeth deep cleaning
Device
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 23, 2022 · Synced Sep 6, 2026, 2:52 PM EDT
Not yet recruiting No phase listed Observational

Serum Inflammatory Protein Concentration During Dental Treatment

NCT07468929
View directory record Official record
Conditions
Periodontal Disease, Periodontal Surgery
Interventions
Blood samples for inflammatory markers, periodontal surgery, Periodontal maintenance, Non-surgical deep cleaning
Other · Procedure
Lead sponsor
Ohio State University
Other
Eligibility
21 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Sep 6, 2026, 2:52 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Dental Implant Healing With TNF-Alpha Inhibitors

NCT06538870
View directory record Official record
Conditions
Edentulism, Dental Implants, TNF-alpha Inhibitors
Interventions
Placement of dental implants
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 6, 2026, 2:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treatment of Periodontitis With Er:YAG Laser

NCT03628872
View directory record Official record
Conditions
Generalized Moderate Chronic Periodontitis, Generalized Severe Chronic Periodontitis, Periodontal Diseases
Interventions
Scaling and root planing, Er:YAG Laser, Hand instruments
Procedure · Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 8, 2024 · Synced Sep 6, 2026, 2:52 PM EDT
Completed Phase 1Phase 2 Interventional

The Anesthetic and Analgesic Effect of Adjunct Liposomal Bupivacaine in Periodontal Surgical Procedures

NCT07725731
View directory record Official record
Conditions
Periodontal Surgery
Interventions
0.5% Bupivacaine HCl, Liposomal Bupivacaine (EXPAREL®)/Bupivacaine
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 89 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 6, 2026, 2:52 PM EDT
Completed No phase listed Observational

Systemic Markers of Inflammation: 9- and 12-Month Follow-Up Post Non-Surgical Periodontal Therapy

NCT04312542
View directory record Official record
Conditions
SRP, Minocycline HCl Microspheres, Biomarkers
Interventions
Measurement of Biomarkers
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 22, 2022 · Synced Sep 6, 2026, 2:52 PM EDT
Completed Phase 1 Interventional

Impact of Parathyroid Hormone (PTH) on Osseous Cavity

NCT00277706
View directory record Official record
Conditions
Bone Loss, Periodontitis
Interventions
Periodontal surgery, FORTEO, Placebo, Vitamin D and Calcium
Procedure · Drug · Dietary Supplement
Lead sponsor
University of Michigan
Other
Eligibility
30 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 6, 2009 · Synced Sep 6, 2026, 2:52 PM EDT
Completed Not applicable Interventional Results available

GUIDOR® Growth Factor Enhanced Bone Graft Substitute for the Treatment of Periodontal Defects 6-months Post-Surgery

NCT01728844
View directory record Official record
Conditions
Alveolar Bone Loss, Periodontal Diseases
Interventions
beta-tricalcium phosphate alone, GFeBGS 0.1%, GFeBGS 0.3%, GFeBGS 0.4%
Device
Lead sponsor
Sunstar Americas
Industry
Eligibility
25 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
6
States / cities
Birmingham, Alabama • Fullerton, California • Aurora, Colorado + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2020 · Synced Sep 6, 2026, 2:52 PM EDT
Completed Not applicable Interventional Results available

An RCT Comparing Xenograft and Allograft for Ridge Preservation

NCT02330523
View directory record Official record
Conditions
Tooth Loss
Interventions
allograft + x-link collagen membrane, xenograft + non-x-link collagen
Device
Lead sponsor
McGuire Institute
Industry
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 17, 2016 · Synced Sep 6, 2026, 2:52 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Periodontal Inflammation and Epigenetics in Obese Individuals

NCT07610902
View directory record Official record
Conditions
Obesity, Periodontitis
Interventions
Non-surgical periodontal therapy will be administered
Procedure
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 6, 2026, 2:52 PM EDT
Completed Not applicable Interventional Results available

CopiOs® Pericardium Membrane for Localized Alveolar Ridge Augmentation

NCT00889265
View directory record Official record
Conditions
Alveolar Ridge Defect
Interventions
CopiOs Pericardium Membrane
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
4
States / cities
Aurora, Colorado • Indianapolis, Indiana • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2014 · Synced Sep 6, 2026, 2:52 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Association of Periodontal Inflammation on Immune Response in Wound Healing

NCT04805320
View directory record Official record
Conditions
Inflammation of Mouth
Interventions
Dental Extraction
Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
21 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Sep 6, 2026, 2:52 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Importance of Periostin in Periodontal Health and Disease

NCT01180920
View directory record Official record
Conditions
Periodontal Disease, Non-diseased Patients
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
21 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 1, 2014 · Synced Sep 6, 2026, 2:52 PM EDT