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Showing 1–24 of 57 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Periodontal surgery Clear all
Recruiting Not applicable Interventional

Patient-reported Outcomes of Donor Site Healing Using Different Palatal Protection Techniques

NCT06892496
View directory record Official record
Conditions
Mucosal Erosion, Gingival Recession
Interventions
Visual Analog scale (VAS) questionnaire, Vacuum-formed retainer (VFR) technique, 3-D printed acrylic resin stent (3DS) technique, Flowable resin composite stent (FRC) technique, Photographs of the patient's palate, Measuring graft dimensions, Chairside Polymer Stent
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Sep 3, 2026, 4:19 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Improve Diabetic Glucose Control

NCT06890676
View directory record Official record
Conditions
Periodontitis, Gingivitis, Periodontal Disease, Periodontal Infections, Oral Infections, Periapical Infections, Pneumonia, Diabetes
Interventions
Comprehensive Oral Evaluation, Intraoral Complete Radiographic Series, • Teledentistry-synchronous and asynchronous, Periodontal Therapy, Periodontal Maintenance Procedure, Application of Caries Arresting Medicament, Oral Hygiene Assistance, Referral for Treatment of Acute Oral Infection
Other · Procedure
Lead sponsor
Missouri Department of Health and Senior Services
Other
Eligibility
60 Years to 100 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Jefferson City, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 25, 2025 · Synced Sep 3, 2026, 4:19 PM EDT
Not listed Phase 4 Interventional

Evaluation of Pharmacogenomics Testing to Precision Prescriptions in Periodontal Patients

NCT05467436
View directory record Official record
Conditions
Oral Surgeries
Interventions
Local anesthetics, IV sedation drugs and analgesics.
Drug
Lead sponsor
Augusta University
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 19, 2022 · Synced Sep 3, 2026, 4:19 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis

NCT03553095
View directory record Official record
Conditions
Chronic Periodontitis, Depression
Interventions
Periodontal Surgery
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 99 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Sep 3, 2026, 4:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Emdogain Minimally Invasive Surgical Technique

NCT02551770
View directory record Official record
Conditions
Periodontitis
Interventions
Scaling and root planing, Scaling and root planing without Emdogain, Emdogain application
Procedure · Device
Lead sponsor
Institut Straumann AG
Industry
Eligibility
21 Years to 85 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
2
States / cities
Cullman, Alabama • Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 16, 2019 · Synced Sep 3, 2026, 4:19 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Utilization of a Videoscope in Periodontal Regeneration

NCT05275192
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
Videoscope-assisted periodontal regeneration minimally invasive surgery, Periodontal regeneration minimally invasive surgery, Guided tissue regeneration surgery
Device · Procedure
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 3, 2026, 4:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Utilization of a Periodontal Endoscope in Nonsurgical Periodontal Therapy

NCT05293301
View directory record Official record
Conditions
Periodontitis, Adult
Interventions
Use of Periodontal Endoscope (Perioscopy®) to enhance visualization while performing teeth deep cleaning, Use of traditional loupes to enhance magnification to enhance visualization while performing teeth deep cleaning
Device
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 23, 2022 · Synced Sep 3, 2026, 4:19 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Comparison of Two Methods of Covering a Single Lower Front Tooth With Receded Gums

NCT06037161
View directory record Official record
Conditions
Recession, Gingival
Interventions
Mandibular Incisor root coverage procedure
Procedure
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Sep 3, 2026, 4:19 PM EDT
Completed Phase 3 Interventional

Control of Periodontal Infections

NCT01098448
View directory record Official record
Conditions
Periodontitis
Interventions
scaling and root planing, local tetracycline, systemic metronidazole and amoxicillin, surgery, local antibiotics and systemic metronidazole and amoxicillin, local tetracycline and periodontal surgery, periodontal surgery and systemic metronidazole and amoxicillin, surgery, local tetracycline, systemic metronidazole and amoxicillin
Other · Drug
Lead sponsor
The Forsyth Institute
Other
Eligibility
20 Years and older
Enrollment
187 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2004
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 1, 2010 · Synced Sep 3, 2026, 4:19 PM EDT
Withdrawn Phase 4 Interventional

Pilot Study: Effect of Dexamethasone vs Vicodin in Reducing Post-operative Pain

NCT04008043
View directory record Official record
Conditions
Oral Surgery
Interventions
Vicodin, Dexamethasone
Drug
Lead sponsor
Boston University
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 12, 2019 · Synced Sep 3, 2026, 4:19 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg

NCT03762915
View directory record Official record
Conditions
SRP, Minocycline HCl Microspheres, Biomarkers
Interventions
minocycline HCl microspheres
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced Sep 3, 2026, 4:19 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Microsurgery and Periodontal Healing

NCT07054008
View directory record Official record
Conditions
Periodontal Diseases
Interventions
Microsurgical approach with Digital Microscope
Procedure
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 18 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Sep 3, 2026, 4:19 PM EDT
Completed Not applicable Interventional Results available

GUIDOR® Growth Factor Enhanced Bone Graft Substitute for the Treatment of Periodontal Defects 6-months Post-Surgery

NCT01728844
View directory record Official record
Conditions
Alveolar Bone Loss, Periodontal Diseases
Interventions
beta-tricalcium phosphate alone, GFeBGS 0.1%, GFeBGS 0.3%, GFeBGS 0.4%
Device
Lead sponsor
Sunstar Americas
Industry
Eligibility
25 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
6
States / cities
Birmingham, Alabama • Fullerton, California • Aurora, Colorado + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2020 · Synced Sep 3, 2026, 4:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Thick vs. Thin Acellular Dermal Matrix (ADM)

NCT03392038
View directory record Official record
Conditions
Gingival Recession
Interventions
Thin ADM, Thick ADM
Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 9, 2020 · Synced Sep 3, 2026, 4:19 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

A Clinical Trial Testing Root Coverage With Acellular Dermal Matrix in Thin and Thick Gingival Biotypes

NCT03057730
View directory record Official record
Conditions
Gingival Recession
Interventions
Acellular Dermal Matrix
Biological
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 19, 2024 · Synced Sep 3, 2026, 4:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treatment of Periodontitis With Er:YAG Laser

NCT03628872
View directory record Official record
Conditions
Generalized Moderate Chronic Periodontitis, Generalized Severe Chronic Periodontitis, Periodontal Diseases
Interventions
Scaling and root planing, Er:YAG Laser, Hand instruments
Procedure · Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 8, 2024 · Synced Sep 3, 2026, 4:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Controlled Study Comparing REPaiR® and MIST Therapies for Treatment of Periodontitis

NCT04169139
View directory record Official record
Conditions
Periodontal Diseases
Interventions
MIST (minimally invasive surgical therapy)
Device
Lead sponsor
McGuire Institute
Industry
Eligibility
18 Years to 75 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 29, 2023 · Synced Sep 3, 2026, 4:19 PM EDT
Terminated No phase listed Interventional Results available

Safety and Efficacy of Periodontal Surgery in Supra-alveolar-type Defects With or Without Straumann® Emdogain

NCT01614925
View directory record Official record
Conditions
Periodontal Attachment Loss, Periodontal Diseases
Interventions
Emdogain, Periodontal surgery
Device · Procedure
Lead sponsor
Institut Straumann AG
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 30, 2020 · Synced Sep 3, 2026, 4:19 PM EDT
Completed No phase listed Observational

Microbes and Bariatric Surgery

NCT01130207
View directory record Official record
Conditions
Obesity, Diabetes, Periodontal Disease
Interventions
Not listed
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 18, 2014 · Synced Sep 3, 2026, 4:19 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Association of Periodontal Inflammation on Immune Response in Wound Healing

NCT04805320
View directory record Official record
Conditions
Inflammation of Mouth
Interventions
Dental Extraction
Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
21 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Sep 3, 2026, 4:19 PM EDT
Completed No phase listed Observational

Patient-Reported Probiotic Use During Periodontal Therapy in Periodontitis

NCT07619040
View directory record Official record
Conditions
Periodontitis, Probiotic, Oral Hygiene, Oral Health, Periodontal Therapy
Interventions
non surgical periodontal therapy
Procedure
Lead sponsor
Medipol University
Other
Eligibility
18 Years to 70 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 3, 2026, 4:19 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Shaping the Indications for Periodontal Adjunctive Antibiotics in Dental Practice

NCT06131021
View directory record Official record
Conditions
Periodontitis, Periodontal Diseases, Periodontal Pocket
Interventions
Amoxicillin, Metronidazole, Placebo
Drug · Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
35 Years and older
Enrollment
236 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 3, 2026, 4:19 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Platelet Rich Fibrin and Autologous Fibrin Glue

NCT03734458
View directory record Official record
Conditions
Gingival Recession
Interventions
Group A - PRF plus AFG with a CAF, Group B - PRF only with a CAF, Group C - CTG with a CAF
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2019 · Synced Sep 3, 2026, 4:19 PM EDT
Active, not recruiting No phase listed Observational

Orbital Fractures Registry

NCT03887988
View directory record Official record
Conditions
Orbital Fractures, Blow Out Fracture of Orbit
Interventions
Primary "early" reconstruction, Nonsurgical, Primary "delayed" reconstruction, Secondary reconstruction
Procedure · Other
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Sep 3, 2026, 4:19 PM EDT