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Conditions: Hypertriglyceridemia
Interventions: DHA-rich fish oil versus Phospholipid-rich fish oil; Dietary Supplement
Lead sponsor: Arctic Nutrition AS; Industry
Eligibility: 18 Years to 59 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013
U.S. locations: 1
States / cities: Addison, Illinois

Conditions: Alcoholism
Interventions: Prazosin medication, Placebo medication; Drug
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years and older
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: PTSD
Interventions: Estradiol, Placebo oral tablet, Prolonged Exposure (PE) therapy; Drug · Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 83 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania • Houston, Texas

Conditions: Primary Biliary Cirrhosis
Interventions: Obeticholic Acid (OCA), Placebo; Drug
Lead sponsor: Intercept Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 217 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 15
States / cities: Sacramento, California • San Diego, California • Aurora, Colorado + 11 more

Conditions: Melanoma
Interventions: Talimogene Laherparepvec, Pembrolizumab, Placebo; Drug
Lead sponsor: Amgen; Industry
Eligibility: 18 Years to 95 Years
Enrollment: 713 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2021
U.S. locations: 41
States / cities: Birmingham, Alabama • Mobile, Alabama • Beverly Hills, California + 32 more

Conditions: Diabetes
Interventions: BMS-903452, Placebo; Drug
Lead sponsor: Bristol-Myers Squibb; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 104 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 2
States / cities: Miramar, Florida • Austin, Texas

Conditions: Psoriasis
Interventions: Cyclosporine; Drug
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years to 70 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Major Depressive Disorder
Interventions: Placebo, Escitalopram, JNJ-18038683; Drug
Lead sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 67 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 26
States / cities: Little Rock, Arkansas • Beverly Hills, California • Glendale, California + 23 more

Conditions: Salmonella
Interventions: CVD 1902, a Salmonella enterica Serovar Paratyphi A live, oral vaccine, Placebo; Biological · Other
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 45 Years
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 2
States / cities: Baltimore, Maryland

Conditions: Respiratory Syncytial Virus Infections
Interventions: RSV cps2 Vaccine, Placebo Vaccine; Biological
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 6 Months to 24 Months
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2013
U.S. locations: 2
States / cities: Baltimore, Maryland • Laurel, Maryland

Conditions: Pulmonary Arterial Hypertension
Interventions: MTT with antibiotic preconditioning + fiber supplementation, MTT with antibiotic preconditioning + placebo supplementation, MTT with placebo + placebo supplementation.; Drug · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 75 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Homocystinuria
Interventions: SYNB1353; Drug
Lead sponsor: Synlogic; Industry
Eligibility: 18 Years to 64 Years
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: High Point, North Carolina

Conditions: Clostridium Difficile Infection
Interventions: Vancomycin Oral Capsule, Placebo Oral Capsule; Drug
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 18 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Drug Safety
Interventions: Hydrolyzed milk protein mixture, Glycerol placebo; Dietary Supplement
Lead sponsor: Ambryx Biotechnology; Industry
Eligibility: 35 Years to 60 Years
Enrollment: 73 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Waco, Texas

Conditions: Subarachnoid Hemorrhage, Stroke
Interventions: IV acetaminophen, Oral acetaminophen, Oral placebo, IV placebo; Drug
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Stress
Interventions: Placebo Control Form 1, Relaxation Active Study Product 1.1, Placebo Control Form 2, Relaxation Active Study Product 2.1, Placebo Control Form 3, Relaxation Active Study Product 3.1, Placebo Control Form 4, Relaxation Active Study Product 4.1, Relaxation Active Study Product 4.2; Dietary Supplement
Lead sponsor: Radicle Science; Industry
Eligibility: 21 Years to 105 Years
Enrollment: 1,700 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Del Mar, California

Conditions: Traumatic Brain Injury (TBI), Chronic Traumatic Encephalopathy (CTE)
Interventions: Fish Oil (DPA+EPA 2:1 ratio) Capsules, High Oleic Safflower Oil Capsules; Dietary Supplement
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years to 25 Years · Male only
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Snakebite, Envenoming, Snake
Interventions: Varespladib intravenous form, varespladib-methyl- oral form, Placebo intravenous form, Placebo - oral form; Drug
Lead sponsor: Ophirex, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 10
States / cities: Phoenix, Arizona • Tucson, Arizona • Palm Springs, California + 7 more

Conditions: Family Member
Interventions: Bio-D-Mulsion Forte®, Placebo; Dietary Supplement · Other
Lead sponsor: University of Miami; Other
Eligibility: 55 Years and older
Enrollment: 101 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Insulin Sensitivity
Interventions: Sevelamer, Synbiotic, Maltodextrin, High Fat diet, Low Fat diet; Drug · Other
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2020
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Smoking Cessation, Cigarette Smoking, Smoking (Tobacco) Addiction
Interventions: Nicotine Film; Drug
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years to 55 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Breast Cancer
Interventions: Ribociclib, Adjuvant endocrine therapy, Placebo; Drug
Lead sponsor: Novartis Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 33
States / cities: Tucson, Arizona • Fayetteville, Arkansas • Bakersfield, California + 28 more

Conditions: Schizophrenia
Interventions: RISPERDAL CONSTA, Paliperidone palmitate; Drug
Lead sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Industry
Eligibility: 18 Years and older
Enrollment: 1,221 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 15
States / cities: Birmingham, Alabama • Little Rock, Arkansas • Cerritos, California + 12 more

Conditions: Healthy Volunteers
Interventions: HSV529, Placebo; Biological · Other
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years to 40 Years
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Bethesda, Maryland

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Bioavailability of EPA and DHA From Two Dietary Supplements

Study of the Medication Prazosin for Alcohol Dependence

Estrogen and Fear in PTSD

Phase 3 Study of Obeticholic Acid in Patients With Primary Biliary Cirrhosis

Pembrolizumab With Talimogene Laherparepvec or Placebo in Unresected Melanoma

Safety Study of BMS-903452 in Healthy Subjects (Panel 1-7) & Relative Bioavailability of the Crystalline and Amorphous Forms of BMS-903452 [Panels 4, 6, 11 & 12(Part A)], and Subjects With Type 2 Diabetes Mellitus (Part B)

The Effectiveness of Lower Cyclosporine Doses for Psoriasis

A Safety and Effectiveness Study of JNJ-18038683 in Patients With Moderate to Severe Depression

Safety and Immunogenicity of CVD 1902 Oral Attenuated Vaccine to Prevent S. Paratyphi A Infection

Evaluating the Safety and Immune Response to a Single Dose of a Respiratory Syncytial Virus (RSV) Vaccine in RSV-Seronegative Infants and Children

A Pilot Study of Microbiota Transplant With Antibiotic Preconditioning and Fiber Supplementation in Pulmonary Arterial Hypertension (GUT RESTORE-PAH)

Safety, Tolerability and Pharmacodynamics of SYNB1353 in Healthy Adult Volunteers

Vancomycin for the Treatment of NAAT(+)/Toxin(-) C. Difficile

Clinical Safety of a Novel Milk Protein Peptide

Clinical, Pharmacological and Molecular Effects of IV and Oral Acetaminophen in Adults With aSAH

Radicle Relaxation 24: A Study of Health and Wellness Products on Stress and Related Health Outcomes

The Effects of Fish Oil Supplementation on the Brain Health of Collegiate Football Athletes

Broad-spectrum Rapid Antidote: Varespladib IV to Oral Trial for Snakebite (BRAVIO)

Vitamin D's Effect on Physical Performance in the Elderly

Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim 1)

Effects of Random Nicotine Delivery on Smoking Cessation

Adjuvant Ribociclib With Endocrine Therapy in Hormone Receptor+/HER2- High Risk Early Breast Cancer

Comparison of Paliperidone Palmitate and RISPERDAL CONSTA in Patients With Schizophrenia

Study of the Safety of a Particular Herpes Vaccine in Adults With or Without Herpes Infection