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ClinicalTrials.gov public records Last synced Oct 7, 2026, 7:36 AM EDT

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Showing 49–70 of 70 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Positive Airway Pressure (PAP) therapy Clear all

Conditions: Obstructive Sleep Apnea (OSA)
Interventions: Continuous positive airway pressure (CPAP), Mask exhaust port flow; Device · Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 21 Years to 70 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Insomnia, Sleep-Disordered Breathing
Interventions: AirCurve 10 ASV; Device
Lead sponsor: ResMed; Industry
Eligibility: 18 Years and older
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Apnea, Sleep Disorders, Overweight and/or Obesity
Interventions: Berobenatide, Placebo; Drug · Other
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years and older
Enrollment: 258 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 3
States / cities: Cullman, Alabama • Bradenton, Florida • Maplewood, Minnesota

Conditions: Obstructive Sleep Apnea of Adult
Interventions: SleepWell24 Application, Usual Care Plus Activity Monitor; Behavioral · Other
Lead sponsor: Arizona State University; Other
Eligibility: 21 Years and older
Enrollment: 119 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Scottsdale, Arizona

Conditions: Obstructive Sleep Apnea
Interventions: CPAP Treatment; Device
Lead sponsor: Ulysses Magalang MD; Other
Eligibility: 18 Years to 75 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Down Syndrome, Obstructive Sleep Apnea
Interventions: Family-informed intervention, Standard Clinical Care; Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 6 Years to 18 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 3
States / cities: Miami, Florida • Cincinnati, Ohio • Philadelphia, Pennsylvania

Conditions: Sleep Apnea
Interventions: PAP Adherence Program, Active Control; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 50 Years and older
Enrollment: 106 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Sepulveda, California

Conditions: Obstructive Sleep Apnea
Interventions: S9 Elite with Acclimate, S9 Elite; Device
Lead sponsor: ResMed; Industry
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Sleep Disordered Breathing
Interventions: CPAP/BiPAP; Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 8 Years to 18 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Sleep Apnea, Obstructive
Interventions: Portable (Embla Embletta X30 system and Respironic REMStar Auto M series with CFlex), Standard polysomnography (PSG); Other
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years and older
Enrollment: 373 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Obstructive Sleep Apnea, Cognitive Change
Interventions: CATNAP MI; Behavioral
Lead sponsor: Washington State University; Other
Eligibility: 40 Years and older
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Eagle Butte, South Dakota

Conditions: Sleep Apnea Syndrome, Obstructive Sleep Apnea, COPD, Overlap Syndrome, Quality of Life, Neurocognitive Function, Sleepiness, Elderly, Positive Airway Pressure
Interventions: Positive airway pressure, Conservative care (control arm); Device · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 60 Years and older
Enrollment: 668 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2027
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Obstructive Sleep Apnea
Interventions: Maridebart cafraglutide, Placebo; Drug
Lead sponsor: Amgen; Industry
Eligibility: 18 Years to 99 Years
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 13
States / cities: Northridge, California • Rolling Hills Estates, California • Brandon, Florida + 10 more

Conditions: Post Traumatic Stress Disorder, Obstructive Sleep Apnea, Substance Use Disorder, Residential Treatment Program
Interventions: Positive Airway Pressure Device; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 194 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: San Diego, California

Conditions: Obstructive Sleep Apnea, Sleep Apnea, Sleep-disordered Breathing
Interventions: Positive Pressure Therapy (PAP), LifeStyle Counseling; Device · Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 75 Years
Enrollment: 111 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Down Syndrome, Obstructive Sleep Apnea
Interventions: Open-ended semi-structured interviews; Behavioral
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 6 Years to 17 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Sleep Apnea, Sleep Disturbance
Interventions: Couples-based treatment- Patient, Couples-based treatment- Partner, Information control- Patient, Information control- Partner; Behavioral · Other
Lead sponsor: University of Utah; Other
Eligibility: 35 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Tuscon, Arizona • Salt Lake City, Utah

Conditions: Sleep Apnea, Obstructive
Interventions: Positive Airway Pressure (PAP), Oral Appliance (OA); Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 131 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 4
States / cities: Redwood City, California • Boston, Massachusetts • Philadelphia, Pennsylvania + 1 more

Conditions: Heart Failure, Sleep Apnea Syndromes
Interventions: Continuous positive airway pressure, Nocturnal supplemental oxygen, Healthy Lifestyle and Sleep Education; Device · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2020
U.S. locations: 2
States / cities: West Haven, Connecticut • Boston, Massachusetts

Conditions: Diabetes Mellitus Type 2
Interventions: Positive Airway Pressure therapy, Lifestyle counseling; Device · Behavioral
Lead sponsor: ResMed; Industry
Eligibility: 18 Years and older
Enrollment: 416 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 11
States / cities: Mission Viejo, California • Temecula, California • Coral Gables, Florida + 8 more

Conditions: Obstructive Sleep Apnea, Atrial Fibrillation
Interventions: Cardiac Ablation for Atrial Fibrillation; Procedure
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Redwood City, California

Conditions: Obstructive Sleep Apnea (OSA)
Interventions: Positive airway pressure (PAP) therapy, Sleep dental device, Atomoxetine-oxybutynin; Device · Drug
Lead sponsor: Sairam Parthasarathy; Other
Eligibility: 18 Years and older
Enrollment: 2,400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2032
U.S. locations: 4
States / cities: Tucson, Arizona • Redwood City, California • Miami, Florida + 1 more

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Assessment of Circuit Rebreathing During CPAP Therapy

CPAP vs ASV for Insomnia

A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Use a Breathing Machine (PAP) (VESPER-OSA 1)

SleepWell24: An Innovative Smartphone Application to Improve PAP Adherence

Effects of PAP Treatment of OSA in Patients With Heart Failure

Positive Airway Pressure (PAP) for Children With Down Syndrome (DS) and Obstructive Sleep Apnea Syndrome (OSAS)

Addressing Insufficient PAP Use in Older Veterans

Evaluation of Acclimate Feature for Positive Airway Pressure (PAP) Therapy

Continuous Positive Airway Pressure and Cardiometabolic Risk

Portable Monitoring for Diagnosis and Management of Sleep Apnea

Cognition After OSA Treatment Among Native American People (CATNAP)

Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)

Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy

OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit

Effects of Continuous Positive Airway Pressure (CPAP) on Glucose Metabolism

Investigating the Experience of Living With Down Syndrome and Obstructive Sleep Apnea Syndrome (Stage 1)

Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples With Implications for Alzheimer's Disease Risk

Comparative Outcomes Management With Electronic Data Technology (COMET) Study

Oxygen Versus PAP for Sleep Apnea in Heart Failure

GLYCOSA Study:Effect of PAP Treatment on Glycemic Control in Patients With Type 2 Diabetes

Effects of PAP on Afib Recurrence Risk After Catheter Ablation in OSA Patients

A Comparative Effectiveness Study of Positive Airway Pressure (PAP) Therapy, Dental Device, and Atomoxetine-Oxybutynin for Treatment of Obstructive Sleep Apnea in Adults