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ClinicalTrials.gov public records Last synced Oct 2, 2026, 4:10 AM EDT

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Showing 25–48 of 70 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Positive Pressure Therapy (PAP) Clear all
Completed Phase 4 Interventional Results available

Oxygen Versus PAP for Sleep Apnea in Heart Failure

NCT01807897
View directory record Official record
Conditions
Heart Failure, Sleep Apnea Syndromes
Interventions
Continuous positive airway pressure, Nocturnal supplemental oxygen, Healthy Lifestyle and Sleep Education
Device · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
2
States / cities
West Haven, Connecticut • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Oct 2, 2026, 4:10 AM EDT
Recruiting Not applicable Interventional

Obstructive Sleep Apnea Non-PAP Outcomes and Viable Alternatives

NCT07074288
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
MAD, HGNS
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Oct 2, 2026, 4:10 AM EDT
Recruiting Not applicable Interventional

The Recovery in Stroke Using PAP Study

NCT04130503
View directory record Official record
Conditions
Ischemic Stroke, Obstructive Sleep Apnea
Interventions
PAP, HLE
Device · Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 5, 2025 · Synced Oct 2, 2026, 4:10 AM EDT
Completed Not applicable Interventional

Study of the Resvent RXiBreeze™ PAP System to Treat Obstructive Sleep Apnea

NCT06008678
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
RXiBreeze PAP System, Model RXiBreeze 20A
Device
Lead sponsor
Resvent Holding USA LTD
Industry
Eligibility
22 Years and older
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
9
States / cities
Burlingame, California • Chula Vista, California • Mountain View, California + 6 more
Source: ClinicalTrials.gov public record
Updated Dec 2, 2024 · Synced Oct 2, 2026, 4:10 AM EDT
Completed Not applicable Interventional Results available

Comparing Auto-adjustable Positive Airway Pressure to Continuous Positive Airway Pressure in Children With Sleep Apnea

NCT01846988
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
crossover treatment (REMstar Auto A-Flex)
Device
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
5 Years to 20 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 23, 2021 · Synced Oct 2, 2026, 4:10 AM EDT
Recruiting Phase 3 Interventional

A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Use a Breathing Machine (PAP) (VESPER-OSA 1)

NCT07823608
View directory record Official record
Conditions
Apnea, Sleep Disorders, Overweight and/or Obesity
Interventions
Berobenatide, Placebo
Drug · Other
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
258 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
3
States / cities
Cullman, Alabama • Bradenton, Florida • Maplewood, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 2, 2026, 4:10 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Assessing the Validity of the PAP Problems Triage Tool in Patients With PAP Treatment for Obstructive Sleep Apnea

NCT05530967
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA)
Interventions
TT, VE
Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
355 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Fontana, California
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Oct 2, 2026, 4:10 AM EDT
Completed Phase 2 Interventional Results available

Apnea, Bariatric Surgery Versus Continuous Positive Airway Pressure (CPAP) Trial

NCT01187771
View directory record Official record
Conditions
Obstructive Sleep Apnea, Obesity
Interventions
Laparoscopic Gastric Banding, Continuous Positive Airway Pressure
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 65 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 4, 2019 · Synced Oct 2, 2026, 4:10 AM EDT
Completed Not applicable Interventional

SleepWell24: An Innovative Smartphone Application to Improve PAP Adherence

NCT03156283
View directory record Official record
Conditions
Obstructive Sleep Apnea of Adult
Interventions
SleepWell24 Application, Usual Care Plus Activity Monitor
Behavioral · Other
Lead sponsor
Arizona State University
Other
Eligibility
21 Years and older
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 16, 2019 · Synced Oct 2, 2026, 4:10 AM EDT
Recruiting Not applicable Interventional

Community Health Advocates for Motivating PAP Use in Our Neighborhoods.

NCT06047353
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Motivational Enhancement Therapy, Positive Airway Pressure (PAP) therapy
Behavioral · Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 100 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Oct 2, 2026, 4:10 AM EDT
Recruiting No phase listed Observational

MicroRNAs as Biomarkers for Obstructive Sleep Apnea

NCT06189755
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Positive Airway Pressure
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 75 Years
Enrollment
500 participants
Timeline
2024 – 2028
U.S. locations
2
States / cities
Columbus, Ohio • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 2, 2026, 4:10 AM EDT
Recruiting Not applicable Interventional

Assessment of Circuit Rebreathing During CPAP Therapy

NCT07062770
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA)
Interventions
Continuous positive airway pressure (CPAP), Mask exhaust port flow
Device · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Oct 2, 2026, 4:10 AM EDT
Completed Not applicable Interventional Results available

Comparative Outcomes Management With Electronic Data Technology (COMET) Study

NCT01461473
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Positive Airway Pressure (PAP), Oral Appliance (OA)
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
4
States / cities
Redwood City, California • Boston, Massachusetts • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated May 17, 2017 · Synced Oct 2, 2026, 4:10 AM EDT
Completed Not applicable Interventional Results available

Continuous Positive Airway Pressure (CPAP) After Adenotonsillectomy in Children

NCT01554527
View directory record Official record
Conditions
Sleep Apnea, Obstructive, Sleep Apnea Syndromes, Child Behavior Disorders, Attention Deficit Disorder With Hyperactivity, Disorders of Excessive Somnolence
Interventions
CPAP treatment, No CPAP treatment
Procedure · Other
Lead sponsor
University of Michigan
Other
Eligibility
5 Years to 12 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 14, 2019 · Synced Oct 2, 2026, 4:10 AM EDT
Terminated Not applicable Interventional Results available

Continuous Positive Airway Pressure and Cardiometabolic Risk

NCT01403194
View directory record Official record
Conditions
Sleep Disordered Breathing
Interventions
CPAP/BiPAP
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
8 Years to 18 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 13, 2014 · Synced Oct 2, 2026, 4:10 AM EDT
Completed Not applicable Interventional Results available

Continuous Positive Airway Pressure (PAP) Titration and Treatment Versus Auto-adjusting PAP Treatment for Sleep Apnea

NCT00988351
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Continuous positive airway pressure, Auto-adjusting positive airway pressure treatment
Device
Lead sponsor
North Florida Foundation for Research and Education
Other
Eligibility
21 Years to 89 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 3, 2014 · Synced Oct 2, 2026, 4:10 AM EDT
Recruiting Not applicable Interventional

The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study

NCT05988385
View directory record Official record
Conditions
Obstructive Sleep Apnea, Cognitive Decline
Interventions
Positive airway pressure, Oral appliance therapy, Positional therapy
Device
Lead sponsor
California Pacific Medical Center Research Institute
Other
Eligibility
55 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
4
States / cities
Tucson, Arizona • New York, New York • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 2, 2026, 4:10 AM EDT
Recruiting Not applicable Interventional

Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)

NCT04179981
View directory record Official record
Conditions
Sleep Apnea Syndrome, Obstructive Sleep Apnea, COPD, Overlap Syndrome, Quality of Life, Neurocognitive Function, Sleepiness, Elderly, Positive Airway Pressure
Interventions
Positive airway pressure, Conservative care (control arm)
Device · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
60 Years and older
Enrollment
668 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 5, 2026 · Synced Oct 2, 2026, 4:10 AM EDT
Active, not recruiting Phase 3 Interventional

Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy

NCT07226765
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Maridebart cafraglutide, Placebo
Drug
Lead sponsor
Amgen
Industry
Eligibility
18 Years to 99 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
13
States / cities
Northridge, California • Rolling Hills Estates, California • Brandon, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 2, 2026, 4:10 AM EDT
Terminated Not applicable Interventional Results available

Assessment of Continuous Positive Airway Pressure Therapy in OSA and ILD

NCT03901534
View directory record Official record
Conditions
Interstitial Lung Disease, Obstructive Sleep Apnea
Interventions
Continuous positive airway pressure (CPAP) therapy, Nox A1 Recorder
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
2,021 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
2
States / cities
Boston, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 20, 2024 · Synced Oct 2, 2026, 4:10 AM EDT
Recruiting Phase 2 Interventional

The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)

NCT05237505
View directory record Official record
Conditions
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Overlap Syndrome
Interventions
bi-level positive pressure non invasive ventilation, Oxygen gas
Device · Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
40 Years to 79 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 2, 2026, 4:10 AM EDT
Completed Not applicable Interventional Results available

Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography

NCT01175031
View directory record Official record
Conditions
Sleep Apnea Central, Cheyne-Stokes Respiration, Obstructive Sleep Apnea
Interventions
Manipulation of Positive Airway Pressure (PAP)
Other
Lead sponsor
Philips Respironics
Industry
Eligibility
21 Years to 80 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
3
States / cities
Denver, Colorado • Gainesville, Florida • Portage, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 31, 2018 · Synced Oct 2, 2026, 4:10 AM EDT
Completed Not applicable Interventional Results available

CPAP vs ASV for Insomnia

NCT02365064
View directory record Official record
Conditions
Insomnia, Sleep-Disordered Breathing
Interventions
AirCurve 10 ASV
Device
Lead sponsor
ResMed
Industry
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Sep 9, 2021 · Synced Oct 2, 2026, 4:10 AM EDT
Recruiting Not applicable Interventional

Cognition After OSA Treatment Among Native American People (CATNAP)

NCT06227572
View directory record Official record
Conditions
Obstructive Sleep Apnea, Cognitive Change
Interventions
CATNAP MI
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
40 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Eagle Butte, South Dakota
Source: ClinicalTrials.gov public record
Updated Jan 9, 2026 · Synced Oct 2, 2026, 4:10 AM EDT