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ClinicalTrials.gov public records Last synced Sep 21, 2026, 11:43 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Power Knee Clear all
Active, not recruiting Not applicable Interventional

Magnetic Bead Tracking System and eOPRA Implant System With Bionic Prosthesis for Transtibial Amputees

NCT06391697
View directory record Official record
Conditions
Amputation
Interventions
eOPRA Implant System for Transtibial Amputees and Magnetic Bead Tracking System
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
22 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 21, 2026, 11:43 AM EDT
Recruiting Not applicable Interventional

Understanding How Powered Componentry Impacts K2-Level Transfemoral Amputee Gait

NCT06433648
View directory record Official record
Conditions
Amputation, Amputation, Traumatic, Amputation of Knee, Amputation; Traumatic, Limb
Interventions
Ottobock CLeg4 + Ottobock foot, SRALAB Hybrid Knee + Polycentric Ankle, SRALAB Hybrid Knee + Passive Ankle, Ottobock CLeg 4 + Polycentric Ankle
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 95 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 29, 2024 · Synced Sep 21, 2026, 11:43 AM EDT
Completed Not applicable Interventional Results available

Personalizing MPK Prescription

NCT06399471
View directory record Official record
Conditions
Transfemoral Amputation
Interventions
Microprocessor prosthetic knee
Device
Lead sponsor
Georgia Institute of Technology
Other
Eligibility
18 Years to 75 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 13, 2024 · Synced Sep 21, 2026, 11:43 AM EDT
Recruiting Not applicable Interventional

Evaluation of a Neural-Controlled Powered Prosthesis Across Diverse Real-World Tasks

NCT07204912
View directory record Official record
Conditions
Transfemoral Amputation
Interventions
MIT Powered Leg
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Sep 21, 2026, 11:43 AM EDT
Active, not recruiting Not applicable Interventional

Active Knee Prosthesis Study

NCT06700668
View directory record Official record
Conditions
Transfemoral Amputation
Interventions
MIT Powered Knee
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
22 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2026
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 21, 2026, 11:43 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Human-Machine System for the H2 Lower Limb Exoskeleton

NCT02114450
View directory record Official record
Conditions
Stroke, Hemiparesis
Interventions
Robot-assisted training with the H2 lower limb powered exoskeleton, Supervised motor practice
Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2029
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 29, 2024 · Synced Sep 21, 2026, 11:43 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Controlling Locomotion Over Continuously Varying Activities for Agile Powered Prosthetic Legs

NCT06138977
View directory record Official record
Conditions
Amputation
Interventions
Powered prosthesis
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Sep 21, 2026, 11:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Design, Prototyping, and Testing of a Robotic Prosthetic Leg

NCT04616378
View directory record Official record
Conditions
Amputation; Traumatic, Leg, Lower
Interventions
Phase 2 Prescribed Prosthesis, Phase 2 Robotic Prosthetic Leg, Phase 3 No Prosthesis, Phase 3 Robotic Prosthetic Leg, Phase 3 Prescribed Prosthesis
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Aug 28, 2022 · Synced Sep 21, 2026, 11:43 AM EDT
Completed Not applicable Interventional Results available

Determining the Potential Benefit of Powered Prostheses

NCT02828982
View directory record Official record
Conditions
Unilateral Traumatic Amputation, Amputation, Traumatic
Interventions
Powered ankle prosthesis, Dynamic Response Foot
Device
Lead sponsor
Deanna H Gates
Other
Eligibility
21 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 17, 2022 · Synced Sep 21, 2026, 11:43 AM EDT
Not listed No phase listed Observational

Kinematic, Kinetic, and Metabolic Comparison of Bilateral Transfemoral Ambulation With Passive Versus Powered Prosthetic Devices

NCT02366702
View directory record Official record
Conditions
Amputation, Artificial Limbs, Energy Expenditure, Kinetics
Interventions
Lower Limb Powered Knee-Ankle Prosthesis
Device
Lead sponsor
Southern California Institute for Research and Education
Other
Eligibility
18 Years to 45 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2019 · Synced Sep 21, 2026, 11:43 AM EDT
Completed No phase listed Observational Results available

Predictors of the Ability to Protect the Airway in Long-term Ventilated Patients

NCT01618240
View directory record Official record
Conditions
Swallowing Disorder, Aspiration, Long Term Ventilation
Interventions
Muscle Strength Measurement, Ventilator
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 12, 2014 · Synced Sep 21, 2026, 11:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries

NCT03834142
View directory record Official record
Conditions
Acute Pain, Arthropathy of Knee, Arthropathy of Hip, Pain, Postoperative, Kidney Transplant Donor, Bariatric Surgery Candidate
Interventions
NSS-2 Bridge
Device
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 2, 2022 · Synced Sep 21, 2026, 11:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Home-based Velocity Training in Individuals With Total Knee Replacement

NCT01808781
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Exercises plus walking program, Walking only program
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
40 Years to 75 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 11, 2017 · Synced Sep 21, 2026, 11:43 AM EDT
Completed Not applicable Interventional Results available

Clinical Investigation (Beta) of Power Knee Mainstream - Dynamic

NCT04787627
View directory record Official record
Conditions
Prosthesis User, Amputation
Interventions
Power Knee
Device
Lead sponsor
Össur Iceland ehf
Industry
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Silver Spring, Maryland • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 21, 2025 · Synced Sep 21, 2026, 11:43 AM EDT
Not yet recruiting Not applicable Interventional

Evaluating the Bambini Teens Exoskeleton for Pediatric Cerebral Palsy

NCT07146932
View directory record Official record
Conditions
Cerebral Palsy (CP)
Interventions
Pediatric Lower Limb Exoskeleton (Bambini Teens)
Device
Lead sponsor
COSMO ROBOTICS CO., Ltd
Industry
Eligibility
5 Years to 14 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 21, 2025 · Synced Sep 21, 2026, 11:43 AM EDT
Recruiting Not applicable Interventional

A Biomechanical Evaluation of the Ossur Power Knee in Persons With Transfemoral Amputation

NCT06218238
View directory record Official record
Conditions
Transfemoral Amputation, Limb Loss, Limb Absence
Interventions
Powered prosthetic knee joint, Conventional prosthetic knee joint
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
45 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Sep 21, 2026, 11:43 AM EDT
Active, not recruiting Not applicable Interventional

Impact of Powered Knee-Ankle Prosthesis Leg on Everyday Community Mobility and Social Interaction

NCT03204513
View directory record Official record
Conditions
Transfemoral Amputees
Interventions
Vanderbilt Powered Knee-Ankle Prosthesis, Microprocessor (MP) Knee Prosthesis
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 21, 2026, 11:43 AM EDT
Completed Not applicable Interventional

Aquatic Power Training

NCT00904319
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Aquatic Power Training
Other
Lead sponsor
University of Iowa
Other
Eligibility
50 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 24, 2010 · Synced Sep 21, 2026, 11:43 AM EDT
Active, not recruiting Not applicable Interventional

An Osseointegrated Transfemoral Prosthesis Offering Long-Term Bi-Directional Efferent-Afferent Neural Transmission

NCT07615465
View directory record Official record
Conditions
Transfemoral Amputation
Interventions
MIT Powered Knee Prosthesis
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
22 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2026
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 21, 2026, 11:43 AM EDT
Completed Not applicable Interventional Results available

Wearable Lower Extremity Exoskeleton to Promote Walking in Persons With Multiple Sclerosis

NCT02519244
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Ekso® (Wearable lower limb exoskeleton)
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 28, 2019 · Synced Sep 21, 2026, 11:43 AM EDT
Completed Not applicable Interventional

The Effect of Powered-Knee Exoskeleton Assist on Stair Climbing in Acute CVA

NCT03264235
View directory record Official record
Conditions
Stroke, Acute, Gait Disorders, Neurologic
Interventions
Keeogo, Traditional Stair Training
Device · Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 24, 2024 · Synced Sep 21, 2026, 11:43 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Is There an Alternative to Immediate Home Physical Therapy Following Total Knee Arthroplasty

NCT04060251
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
CyMedica e-vive™ System; CY-1000, iGetBetter telemedicine physical therapy
Device · Other
Lead sponsor
Wolfgang Fitz, M.D.
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 6, 2023 · Synced Sep 21, 2026, 11:43 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Heat Therapy and Muscle Function Study

NCT04733287
View directory record Official record
Conditions
Exercise Intolerance, Aging, Heat Therapy, High Intensity Interval Training
Interventions
High Intensity Interval Training of the Knee Extensors, Muscle Heat Therapy, Muscle Disuse, Sham Heat Therapy
Other
Lead sponsor
Brigham Young University
Other
Eligibility
18 Years to 95 Years
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Provo, Utah
Source: ClinicalTrials.gov public record
Updated Feb 1, 2021 · Synced Sep 21, 2026, 11:43 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Modeling, Optimization, and Control Methods for a Personalized Hybrid Walking Exoskeleton

NCT04453943
View directory record Official record
Conditions
Spinal Cord Injuries, Paraplegia, Spinal, Paraplegia, Incomplete
Interventions
Exoskeleton Walking - with or without FES, Exoskeleton Sitting to Standing - with or without FES
Device
Lead sponsor
North Carolina State University
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 30, 2020 · Synced Sep 21, 2026, 11:43 AM EDT