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ClinicalTrials.gov public records Last synced Oct 18, 2026, 2:10 AM EDT

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Showing 1–24 of 204 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Probiotic Supplement Clear all
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Probiotics, Immune Function, and the Brain in Alcohol Consumers

NCT05232682
View directory record Official record
Conditions
Alcohol; Use, Problem
Interventions
Seed DS-01 Daily Synbiotic
Dietary Supplement
Lead sponsor
Brown University
Other
Eligibility
18 Years to 64 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 18, 2026, 2:10 AM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

Probiotic Supplementation in Breastfed Newborn Infants

NCT02286999
View directory record Official record
Conditions
Atopic Dermatitis, Food Allergies
Interventions
B. infantis, Placebo
Drug
Lead sponsor
Emanual Maverakis, MD
Other
Eligibility
1 Day to 7 Days
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Nov 15, 2019 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional

Pilot Trial of a Synbiotic in HIV+ Patients

NCT00688311
View directory record Official record
Conditions
HIV Infection
Interventions
Synbiotic 2000, Placebo
Dietary Supplement
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older · Female only
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Nov 23, 2009 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Probiotic Intake on Intestinal Permeability in Healthy Adults

NCT03611400
View directory record Official record
Conditions
Intestinal Barrier Function
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 50 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 21, 2019 · Synced Oct 18, 2026, 2:10 AM EDT
Not yet recruiting Phase 3 Interventional Accepts healthy volunteers

Povidone Iodine for Caries Prevention

NCT07741409
View directory record Official record
Conditions
Dental Caries
Interventions
Povidone Iodine 5% Soln,Top,Kit, Probiotics, Placebo
Drug · Dietary Supplement
Lead sponsor
Jeffrey A. Banas
Other
Eligibility
1 Year to 3 Years
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Probiotics and Multi-Drug Resistant Urinary Tract Infection

NCT03644966
View directory record Official record
Conditions
Urinary Tract Infections, Recurrent UTI, Antibiotic Resistant Infection
Interventions
Bifidobacterium infantis, Placebo, Antibiotics
Dietary Supplement · Other · Drug
Lead sponsor
Ochsner Health System
Other
Eligibility
18 Years to 90 Years · Female only
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Jefferson, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 12, 2023 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety Evaluation of a Diet and Nutritional Supplementation Program- Purify 2.0

NCT03685552
View directory record Official record
Conditions
Gastrointestinal Symptoms
Interventions
Prog: Purify-2
Other
Lead sponsor
Nature's Sunshine Products, Inc.
Industry
Eligibility
18 Years to 69 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Lehi, Utah
Source: ClinicalTrials.gov public record
Updated Sep 26, 2018 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of a Novel Nutritional Product on Nutrient Gaps and Gut Health in Adults With Occasional Gastrointestinal Issues

NCT06564285
View directory record Official record
Conditions
Gastrointestinal Microbiome, Nutrition, Healthy
Interventions
AG1 - Nutritional Supplement, Placebo
Dietary Supplement
Lead sponsor
Athletic Greens International
Industry
Eligibility
18 Years to 60 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated May 4, 2025 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional

Engineering Gut Microbiome to Target Breast Cancer

NCT03358511
View directory record Official record
Conditions
Breast Cancer
Interventions
Probiotic
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 21, 2020 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional

The Effects of Probiotic Supplementation on State and Trait Stress, Anxiety, and Depression Symptoms in Stressed Adults

NCT07216729
View directory record Official record
Conditions
Anxiety Symptoms, Perceived Stress, Depressive Symptoms
Interventions
Lactobacillus reuteri DSM 17938, Placebo
Dietary Supplement · Other
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years to 45 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional Results available

Effect of Milk Oligosaccharides and Bifidobacteria on the Intestinal Microflora of Children With Autism

NCT02086110
View directory record Official record
Conditions
Autism
Interventions
Synbiotic, Prebiotic
Dietary Supplement
Lead sponsor
University of California, Davis
Other
Eligibility
2 Years to 11 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 1, 2019 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim2)

NCT02127125
View directory record Official record
Conditions
Insulin Sensitivity
Interventions
Maltodextrin, Synbiotic, Sevelamer
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 65 Years
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 11, 2020 · Synced Oct 18, 2026, 2:10 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Impact of B. Adolescentis iVS-1 Probiotic on Gastrointestinal Outcomes

NCT07408518
View directory record Official record
Conditions
Digestive Disease, Gut Health
Interventions
Probiotic, Placebo
Dietary Supplement · Other
Lead sponsor
Synbiotic Health
Industry
Eligibility
18 Years to 75 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Enhancing Efficacy of Mango Polyphenols in Lean and Obese

NCT04970589
View directory record Official record
Conditions
Obesity
Interventions
Mango, Probiotics, Placebo
Other · Dietary Supplement
Lead sponsor
Texas A&M University
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Jul 21, 2021 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional Results available

Double-Blind Trial of a Probiotic Supplement to Reduce the Symptoms of Schizophrenia

NCT01242371
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
Probiotic Supplement, Identical-appearing Placebo
Dietary Supplement
Lead sponsor
Sheppard Pratt Health System
Other
Eligibility
18 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Towson, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 5, 2019 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study to Determine the Effect of Synbiotics in Patients With Pre-diabetes

NCT04428606
View directory record Official record
Conditions
PreDiabetes
Interventions
Metabolic Rheostat, Butyrate Ultra, Placebo
Dietary Supplement
Lead sponsor
Zhaoping Li
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 16, 2022 · Synced Oct 18, 2026, 2:10 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Multi-strain Probiotic Supplement for Digestive Comfort and Well-being in Healthy Women

NCT07831317
View directory record Official record
Conditions
Gastrointestinal Discomfort, Bloating
Interventions
Active: Multi-strain probiotic dietary supplement, Placebo: Placebo
Dietary Supplement
Lead sponsor
Daily Nouri
Industry
Eligibility
25 Years to 45 Years · Female only
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 18, 2026, 2:10 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of a Synbiotic Supplement on a High-protein Diet

NCT03123510
View directory record Official record
Conditions
Obesity
Interventions
Bifidobacterium spp plus bimuno- galacto-oligosaccharides, Placebo
Dietary Supplement
Lead sponsor
South Dakota State University
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Brookings, South Dakota
Source: ClinicalTrials.gov public record
Updated Apr 21, 2017 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional

The Effect of Methylated Vitamin B Complex on Depression

NCT01672372
View directory record Official record
Conditions
Depression
Interventions
Max Stress B, Placebo Max Stress B
Dietary Supplement
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 6, 2014 · Synced Oct 18, 2026, 2:10 AM EDT
Recruiting Phase 2 Interventional

CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial

NCT06949800
View directory record Official record
Conditions
HSIL, High Grade Squamous Intraepithelial Lesion, HPV-Related Squamous Cell Carcinoma, Anal HSIL
Interventions
EXE-346 Probiotic, Placebo, Usual Care High Resolution Anoscopy (HRA)
Drug · Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 18, 2026, 2:10 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Impact of Probiotics on Drug, Vitamin, and Hormone Metabolism

NCT04281407
View directory record Official record
Conditions
Metabolism
Interventions
Visbiome
Dietary Supplement
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 24, 2020 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Not applicable Interventional

Probiotic Supplementation on Weight Loss

NCT03832439
View directory record Official record
Conditions
Bariatric Surgery Candidate
Interventions
Probiotic, microcrystalline cellulose
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 21, 2022 · Synced Oct 18, 2026, 2:10 AM EDT
Completed Phase 2 Interventional Results available

Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO

NCT01465802
View directory record Official record
Conditions
Non Small Cell Lung Cancer (NSCLC)
Interventions
Dacomitinib, Doxycycline, Probiotic, Alclometasone cream
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
79
States / cities
Duarte, California • Fullerton, California • Irvine, California + 49 more
Source: ClinicalTrials.gov public record
Updated Jan 9, 2019 · Synced Oct 18, 2026, 2:10 AM EDT
Active, not recruiting Not applicable Interventional

Probiotics and Insulin Resistance in Obese Asthmatics

NCT05949255
View directory record Official record
Conditions
Asthma, Obesity, Insulin Resistance
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 99 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 16, 2026 · Synced Oct 18, 2026, 2:10 AM EDT