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Showing 1–24 of 77 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Prolonged Exposure Therapy for Posttraumatic Stress Disorder Clear all
Completed Not applicable Interventional

In-Home Exposure Therapy for Veterans With Post Traumatic Stress Disorder (PTSD)

NCT03110302
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Prolonged exposure
Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 13, 2019 · Synced Sep 27, 2026, 11:09 PM EDT
Recruiting Not applicable Interventional

Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center

NCT06210711
View directory record Official record
Conditions
Traumatic Injury, PTSD, Posttraumatic Stress Disorder
Interventions
Treatment as Usual, Brief Prolonged Exposure Therapy
Behavioral
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
3
States / cities
Dallas, Texas • Temple, Texas • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Sep 27, 2026, 11:09 PM EDT
Active, not recruiting Not applicable Interventional

Circadian Influence on Prolonged Exposure Therapy for PTSD

NCT05453162
View directory record Official record
Conditions
PTSD
Interventions
Prolonged Exposure Therapy for Posttraumatic Stress Disorder
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 27, 2026, 11:09 PM EDT
Completed Not applicable Interventional

A Comparison of Web-Prolonged Exposure (Web-PE) and Present-Centered Therapy (PCT) for PTSD Among Active-Duty Military Personnel

NCT02556645
View directory record Official record
Conditions
Posttraumatic Stress Disorders, Combat Disorders
Interventions
Web-PE Therapy, Therapist-Delivered Present-Centered Therapy
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
4
States / cities
Atlanta, Georgia • Philadelphia, Pennsylvania • Killeen, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 8, 2019 · Synced Sep 27, 2026, 11:09 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Ketamine and Prolonged Exposure in PTSD

NCT03960658
View directory record Official record
Conditions
Post-traumatic Stress Disorder
Interventions
ketamine-enhanced prolonged exposure
Drug
Lead sponsor
Minneapolis Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 21, 2021 · Synced Sep 27, 2026, 11:09 PM EDT
Completed Not applicable Interventional Results available

Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders

NCT01338506
View directory record Official record
Conditions
Posttraumatic Stress Disorders, Combat Disorders, Alcohol Dependence, Drug Dependence
Interventions
Concurrent Treatment with Prolonged Exposure (COPE)
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 10, 2020 · Synced Sep 27, 2026, 11:09 PM EDT
Not yet recruiting Early Phase 1 Interventional

PTSD and Alcohol Couples Treatment for Veterans

NCT07388654
View directory record Official record
Conditions
PTSD, AUD
Interventions
COPE + BFIT
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 27, 2026, 11:09 PM EDT
Completed Not applicable Interventional

Psychotherapy Treatment of Deployment-Related PTSD in Primary Care Settings

NCT00974402
View directory record Official record
Conditions
Post-Traumatic Stress Disorders, Stress Disorders, Combat Disorders
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 17, 2014 · Synced Sep 27, 2026, 11:09 PM EDT
Completed Not applicable Interventional Results available

Virtual Reality & D-cycloserine (DCS) for Posttraumatic Stress Disorder (PTSD)

NCT00632632
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
D-Cycloserine, Placebo
Drug · Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 26, 2015 · Synced Sep 27, 2026, 11:09 PM EDT
Completed Not applicable Interventional Results available

Prolonged Exposure Therapy for PTSD and Opioid Use Disorder

NCT04104022
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Opioid-use Disorder
Interventions
Prolonged Exposure Therapy, Attendance-based monetary incentives
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Sep 27, 2026, 11:09 PM EDT
Recruiting Not applicable Interventional

Reducing Posttraumatic Stress Disorder (PTSD) Symptoms in First Responders and Frontline Health Care Workers

NCT05751473
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Prolonged Exposure for Primary Care (PE-PC), EAP Treatment as Usual (TAU)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
410 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
14
States / cities
San Diego, California • Carrollton, Georgia • Ann Arbor, Michigan + 9 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 27, 2026, 11:09 PM EDT
Completed Not applicable Interventional

Project Remission: Maximizing Outcomes With Intensive Treatments for Combat-Related PTSD

NCT03529435
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD)
Interventions
Massed Prolonged Exposure, Intensive Outpatient Prolonged Exposure
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 65 Years
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
4
States / cities
Fort Hood, Texas • San Antonio, Texas • Waco, Texas
Source: ClinicalTrials.gov public record
Updated Aug 7, 2022 · Synced Sep 27, 2026, 11:09 PM EDT
Completed Phase 3 Interventional Results available

Enhancing Exposure Therapy for Post Traumatic Stress Disorder (PTSD): Virtual Reality and Imaginal Exposure With a Cognitive Enhancer

NCT01352637
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
DCS (D-Cycloserine ) + Prolonged Imaginal Exposure, DCS (D-Cycloserine ) + Virtual Reality Exposure, Placebo + Prolonged Imaginal Exposure, Placebo (sugar pill) + Virtual Reality Exposure
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 70 Years
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
5
States / cities
Long Beach, California • Los Angeles, California • Atlanta, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2019 · Synced Sep 27, 2026, 11:09 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

TDCS-Augmented Prolonged Exposure Therapy

NCT04327362
View directory record Official record
Conditions
Posttraumatic Stress Disorder, PTSD, Anxiety, Depression
Interventions
Transcranial Direct Current Stimulation (tDCS), Prolonged Exposure Therapy
Device · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Sep 27, 2026, 11:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Brain Structure and Function Before and After Treatment for Post-Traumatic Stress Disorder

NCT00069225
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 27, 2026, 11:09 PM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers

Enhancing Exposure Therapy for Post-traumatic Stress Disorder

NCT01574118
View directory record Official record
Conditions
Chronic Posttraumatic Stress Disorder
Interventions
Revisiting the Trauma memories, Processing the trauma memories, Psychoeducation, Trauma Memory Retrieval Trial, Exposure to video clips related to the patient's trauma, Breathing retraining, Exposure Homework, Compound extinction
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Aug 28, 2022 · Synced Sep 27, 2026, 11:09 PM EDT
Recruiting Not applicable Interventional

Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder

NCT06740487
View directory record Official record
Conditions
PTSD, Post Traumatic Stress Disorder
Interventions
Traditional Exposure Therapy (ET) Treatment, Stepwise Augmented Reality (AR) Component with Traditional Exposure Treatment for Nonresponders
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Sep 27, 2026, 11:09 PM EDT
Completed Not applicable Interventional Results available

Written Exposure Therapy Versus Prolonged Exposure: a Non-inferiority Trial

NCT03962504
View directory record Official record
Conditions
PTSD
Interventions
trauma-focused treatment
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
3
States / cities
Boston, Massachusetts • Charleston, South Carolina • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 17, 2024 · Synced Sep 27, 2026, 11:09 PM EDT
Completed Phase 4 Interventional Results available

Combination Treatment for Posttraumatic Stress Disorder (PTSD) After the World Trade Center (WTC) Attack

NCT01130103
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Paroxetine, Prolonged Exposure Therapy
Drug · Behavioral
Lead sponsor
Research Foundation for Mental Hygiene, Inc.
Other
Eligibility
18 Years to 70 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 3, 2012 · Synced Sep 27, 2026, 11:09 PM EDT
Completed Not applicable Interventional Results available

Comparative Effectiveness of Two Treatments for Veterans With PTSD

NCT02586064
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Interpersonal Therapy for PTSD, Prolonged Exposure
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
New Orleans, Louisiana • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 6, 2021 · Synced Sep 27, 2026, 11:09 PM EDT
Completed Phase 2 Interventional Results available

Integrated Alcohol Disorder and PTSD Treatment

NCT01601067
View directory record Official record
Conditions
PTSD, Alcoholism
Interventions
Integrated Prolonged Exposure Therapy, Seeking Safety
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 7, 2019 · Synced Sep 27, 2026, 11:09 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Exposure Therapy for Chronic PTSD: Efficacy and Mechanisms

NCT00475241
View directory record Official record
Conditions
Combat Disorders, Posttraumatic Stress Disorder
Interventions
Prolonged Exposure therapy for PTSD, Present centered therapy for PTSD
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 14, 2019 · Synced Sep 27, 2026, 11:09 PM EDT
Recruiting Not applicable Interventional

Project COMET: Massed Prolonged Exposure for PTSD and SUD

NCT06968832
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Substance Use Disorders (SUD), Comorbidity, Trauma and Stressor Related Disorders
Interventions
Massed Prolonged Exposure Therapy (M-PE), Standard outpatient SUD care
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 26, 2025 · Synced Sep 27, 2026, 11:09 PM EDT
Completed Not applicable Interventional Results available

Comparing Virtual Reality Exposure Therapy to Prolonged Exposure

NCT01459705
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic Stress Disorder
Interventions
Prolonged Exposure Therapy (PE), Virtual Reality Exposure Therapy (VRET), Waitlist
Behavioral
Lead sponsor
National Center for Telehealth and Technology
Federal
Eligibility
18 Years to 65 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 13, 2015 · Synced Sep 27, 2026, 11:09 PM EDT