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ClinicalTrials.gov public records Last synced Oct 3, 2026, 8:24 PM EDT

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Showing 1–24 of 44 matching trials from the live ClinicalTrials.gov search.
Conditions
Opioid Use, Pain, Post Operative
Interventions
nCAP Signal Relief Patch, Standard of Care
Device · Other
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years and older
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Total Knee Arthroplasty, Total Knee Arthroplasty Recovery
Interventions
Intra-articular Posteromedial Surgeon Administered (IPSA) Block with LIA, Local Infiltration Analgesia (LIA), Bupivacaine liposome injectable suspension (IPSA block), Bupivacaine liposome injectable suspension (LIA)
Procedure · Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Conditions
Knee Arthropathy, Recurrence, Knee Infection
Interventions
Triathlon Hinge Knee (THK) System
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
Not listed
Enrollment
200 participants
Timeline
2024 – 2034
U.S. locations
2
States / cities
Weston, Florida • Cleveland, Ohio
Conditions
Total Knee Arthroplasty
Interventions
Methadone
Drug
Lead sponsor
AdventHealth
Other
Eligibility
21 Years to 75 Years
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Denver, Colorado
Conditions
Knee Arthroplasty, Total
Interventions
Truliant Total Knee System
Device
Lead sponsor
Exactech
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2035
U.S. locations
5
States / cities
Aurora, Colorado • DeLand, Florida • Las Vegas, Nevada + 2 more
Completed Not applicable Interventional Results available

Persona TM Tibia Clinical Outcomes Study

NCT03589300
Conditions
Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Collagen Disorders and/or Avascular Necrosis of the Femoral Condyle, Post-traumatic Loss of Joint Configuration, Moderate Valgus, Varus, or Flexion Deformities
Interventions
Persona TM Tibia
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
7
States / cities
Torrance, California • Wheat Ridge, Colorado • Honolulu, Hawaii + 4 more
Conditions
Osteo Arthritis Knee, Osteoarthritis
Interventions
Total Knee Replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Baltimore, Maryland • Crosby, Minnesota • Charlotte, North Carolina + 2 more
Completed Not applicable Interventional Accepts healthy volunteers Results available

Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee

NCT00854295
Conditions
Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus, Flexion Deformities
Interventions
NexGen LPS-Flex Mobile Bearing Knee
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
Not listed
Enrollment
266 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2021
U.S. locations
3
States / cities
Tamarac, Florida • Auburn Hills, Michigan • Knoxville, Tennessee
Conditions
Periprosthetic Joint Infection
Interventions
Single Debridement, Antibiotics and Implant Retention, Planned Double Debridement, Antibiotics and Implant Retention
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
490 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2032
U.S. locations
2
States / cities
Jacksonville, Florida • Rochester, Minnesota
Conditions
Total Knee Arthroplasty
Interventions
Continuous femoral catheter block, Lidocaine, Preservative free normal saline
Procedure · Drug · Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Loma Linda, California
Conditions
Flexion Contracture
Interventions
KneeMD
Device
Lead sponsor
Anne Arundel Health System Research Institute
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Annapolis, Maryland
Completed Not applicable Interventional Accepts healthy volunteers

Medacta GMK Sphere® Multicenter Post-Market Outcomes Study

NCT02501733
Conditions
Osteoarthritis
Interventions
Medacta GMK Sphere® Medial Knee Prosthesis
Device
Lead sponsor
Medacta USA
Industry
Eligibility
21 Years to 80 Years
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2024
U.S. locations
5
States / cities
Chicago, Illinois • New Orleans, Louisiana • Oklahoma City, Oklahoma + 2 more
Conditions
Osteoarthritis, Knee, Knee Osteoarthritis, Osteoarthritis Knees Both, Osteoarthritis Knee Left, Osteoarthritis Knee Right, Knee Pain Chronic, Knee Disease, Arthropathy of Knee Joint
Interventions
MicroPort Evolution Medial-Pivot Knee System (Cruciate-substituting), Stryker Triathlon Tritanium Knee System (Condylar Stabilizing)
Device
Lead sponsor
LifeBridge Health
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2030
U.S. locations
1
States / cities
Baltimore, Maryland
Conditions
Arthroplasty, Replacement, Knee
Interventions
Zip Surgical Skin Closure, Steel Staples
Device
Lead sponsor
ZipLine Medical Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Indianapolis, Indiana
Active, not recruiting No phase listed Observational Accepts healthy volunteers

JOURNEY™ II CR Total Knee System

NCT02440672
Conditions
Osteoarthritis, Knee
Interventions
JOURNEY™ II CR Total Knee System (J II CR TKS)
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
22 Years to 75 Years
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2028
U.S. locations
6
States / cities
Phoenix, Arizona • Chicago, Illinois • Annapolis, Maryland + 3 more
Conditions
Distal Femur Fracture
Interventions
Timed Up and Go Test on subjects with ORIF of distal femur fractures, Koos Jr assesment on subjects with ORIF of distal femur fractures, Timed Up and Go Test on subjects with DFR of distal femur fracture, Koos Jr assesment on subjects with DFR of distal femur fracture
Other
Lead sponsor
University of Florida
Other
Eligibility
55 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Conditions
Osteoarthritis
Interventions
Total knee arthroplasty
Procedure
Lead sponsor
Exactech
Industry
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Richmond, Virginia
Conditions
Arthropathy of Knee, Arthritis and/or Post-traumatic Degenerative Problems
Interventions
Optetrak PS, Optetrak Hi-Flex
Device
Lead sponsor
Exactech
Industry
Eligibility
50 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Newport News, Virginia
Conditions
Osteoarthritis
Interventions
Total Knee Arthroplasty, Total Hip Arthroplasty
Procedure
Lead sponsor
Spokane Joint Replacement Center
Other
Eligibility
18 Years and older
Enrollment
10,000 participants
Timeline
2020 – 2030
U.S. locations
1
States / cities
Spokane, Washington
Active, not recruiting Not applicable Interventional

Persona Total Knee Arthroplasty Outcomes Study

NCT02255383
Conditions
Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Moderate Varus, Valgus or Flexion Deformities, Avascular Necrosis of the Femoral Condyle
Interventions
Zimmer Persona Total Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 75 Years
Enrollment
737 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2027
U.S. locations
14
States / cities
Denver, Colorado • Fort Collins, Colorado • Parker, Colorado + 11 more
Completed Not applicable Interventional Results available

Does Implant Design Improve Postoperative Flexion?

NCT00380861
Conditions
Non-inflammatory Arthritis
Interventions
Total knee replacement using the PFC Sigma RPF knee implant., Total knee replacement using the PFC Sigma RP knee implant
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
40 Years to 70 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
4
States / cities
Denver, Colorado • Jacksonville, Florida • Iowa City, Iowa + 1 more
Conditions
Total Knee Replacement, Total Knee Arthroplasty, Pain, Postoperative Pain, Orthopedic Disorders
Interventions
SPRINT Peripheral Nerve Stimulation (PNS) System
Device
Lead sponsor
SPR Therapeutics, Inc.
Industry
Eligibility
21 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
3
States / cities
La Jolla, California • Durham, North Carolina • New Albany, Ohio
Conditions
Arthroplasty, Knee Replacement, Wound Healing
Interventions
Zip Surgical Skin Closure, Steel Staples
Device
Lead sponsor
ZipLine Medical Inc.
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Indianapolis, Indiana
Conditions
Knee Arthropathy
Interventions
Primary Robotic-Assisted Total Knee Arthroplasty with a short tourniquet time, Primary Robotic-Assisted Total Knee Arthroplasty with the use of a tourniquet
Other
Lead sponsor
University of Louisville
Other
Eligibility
21 Years and older
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Louisville, Kentucky