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ClinicalTrials.gov public records Last synced Oct 19, 2026, 10:19 AM EDT

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Showing 25–48 of 53 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Protocolized care Clear all
Recruiting Not applicable Interventional

Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection

NCT05219110
View directory record Official record
Conditions
Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection, Hemolytic-Uremic Syndrome
Interventions
Infusion of 200% maintenance fluids as balanced crystalloid IV solution, Oral fluids; infusion of up to 110% maintenance fluids as balanced crystalloid IV solution
Other
Lead sponsor
University of Calgary
Other
Eligibility
9 Months to 21 Years
Enrollment
1,040 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
22
States / cities
Birmingham, Alabama • Little Rock, Arkansas • La Jolla, California + 19 more
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 19, 2026, 10:19 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Extended Emergence Strategy on Post-Anesthesia Care Unit Events After Outpatient Orthopedic Surgery

NCT07533370
View directory record Official record
Conditions
Perioperative Care, EEG Power Spectra, Delirium - Postoperative
Interventions
Standard of Care EEG-Guided Emergence, Extended EEG Emergence Trajectory
Procedure
Lead sponsor
Harrison Shong-Wen Chow
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 19, 2026, 10:19 AM EDT
Not yet recruiting Not applicable Interventional

Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients

NCT07452406
View directory record Official record
Conditions
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy
Interventions
Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 19, 2026, 10:19 AM EDT
Completed Phase 4 Interventional Results available

Protocolized Initiation of Clonidine to Prevent Dexmedetomidine Withdrawal

NCT05575219
View directory record Official record
Conditions
Withdrawal; Therapeutic Substance
Interventions
Clonidine (without protocolized initiation), Clonidine (protocolized initiation)
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
4 Weeks to 18 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Oct 19, 2026, 10:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reducing Intraoperative Infection Transmission in the Pediatric Operating Room

NCT03992209
View directory record Official record
Conditions
Health Care Associated Infection, Hand Hygiene
Interventions
Standard care, Protocolized care
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
1 Year to 18 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 21, 2022 · Synced Oct 19, 2026, 10:19 AM EDT
Not listed Not applicable Interventional

Integrating Behavioral Health and Primary Care for Comorbid Behavioral and Medical Problems

NCT02868983
View directory record Official record
Conditions
Arthritis, Asthma, Chronic Obstructive Lung Disease, Diabetes, Heart Failure, Hypertension, Anxiety, Chronic Pain, Depression, Fibromyalgia, Insomnia, Irritable Bowel Syndrome, Problem Drinking, Substance Use Disorder
Interventions
Integration
Other
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
4,025 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Oct 19, 2026, 10:19 AM EDT
Completed Not applicable Interventional

Regionalized Pediatric Emergency Care in Rural Pennsylvania

NCT01775033
View directory record Official record
Conditions
Emergencies
Interventions
Multicomponent intervention
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
Up to 18 Years
Enrollment
5,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 27, 2016 · Synced Oct 19, 2026, 10:19 AM EDT
Completed Phase 2 Interventional

Nutrition and Exercise in Critical Illness

NCT03021902
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
IV amino acids, In-bed cycle ergometry exercise
Drug · Device
Lead sponsor
Clinical Evaluation Research Unit at Kingston General Hospital
Other
Eligibility
18 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
7
States / cities
Lexington, Kentucky • Baltimore, Maryland • The Bronx, New York + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Oct 19, 2026, 10:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Patient and Family Centered Care in Advanced Critical Illness

NCT01844492
View directory record Official record
Conditions
Anxiety, Depression
Interventions
The PARTNER Intervention, ICU Usual Care Control
Behavioral · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
1,420 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 20, 2018 · Synced Oct 19, 2026, 10:19 AM EDT
Completed Not applicable Interventional Results available

Smart Telehealth Exercise Intervention to Reduce COPD Readmissions

NCT03089853
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
Neuromuscular electrical stimulation (NMES)
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
40 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 22, 2022 · Synced Oct 19, 2026, 10:19 AM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Improve the Patients' Recovery With Family- Caregivers to End Delirium

NCT05118867
View directory record Official record
Conditions
Delirium
Interventions
iPREPARED
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
60 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 19, 2026, 10:19 AM EDT
Completed Not applicable Interventional Results available

Protocolized Post-Extubation Respiratory Support Study

NCT03288311
View directory record Official record
Conditions
Mechanical Ventilation Complication, Acute Respiratory Failure, Intubation Complication
Interventions
Protocolized post-extubation respiratory support, Usual Care
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
751 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 29, 2023 · Synced Oct 19, 2026, 10:19 AM EDT
Not listed Not applicable Interventional

ROX Index for the Timing of Intubation in Nasal High Flow

NCT04707729
View directory record Official record
Conditions
Acute Hypoxemic Respiratory Failure
Interventions
ROX index algorithm
Diagnostic Test
Lead sponsor
Hospital Universitari Vall d'Hebron Research Institute
Other
Eligibility
18 Years to 120 Years
Enrollment
630 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 15, 2024 · Synced Oct 19, 2026, 10:19 AM EDT
Terminated Not applicable Interventional Results available

HPI (Hypotension Prediction Index) Care Trial

NCT05083403
View directory record Official record
Conditions
Cardiopulmonary Bypass Surgery
Interventions
AcumenTM HPI Software Feature, Non-protocolized Standard of Care
Device · Other
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Oct 19, 2026, 10:19 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Protocolized vs Nonprotocolized Treatment of Adult ED Patients With Acute Severe Pain

NCT00627367
View directory record Official record
Conditions
Acute Pain
Interventions
Hydromorphone, Nonprotocolized
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
21 Years to 64 Years
Enrollment
224 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 19, 2026, 10:19 AM EDT
Not yet recruiting Not applicable Interventional

Emergency Department-Initiated Team-Based Care for Severe Hypertension

NCT07777237
View directory record Official record
Conditions
Severe Hypertension, Hypertension
Interventions
Emergency Department-Initiated Team-Based Care, Usual Care
Other
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 85 Years
Enrollment
700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
4
States / cities
Dearborn, Michigan • Detroit, Michigan • Wyandotte, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 19, 2026, 10:19 AM EDT
Completed Not applicable Interventional

Outcomes Associated With Application of a Normothermia Protocol in Patients With Severe Neurological Insult and Fever

NCT00890604
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Severe Traumatic Brain Injury
Interventions
Stepwise normothermia protocol, Ibuprofen, Acetominophen
Other · Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 30, 2024 · Synced Oct 19, 2026, 10:19 AM EDT
Completed No phase listed Observational

An Analysis of the Outcomes From Protocolized Perioperative Care for Patients Receiving Total Hip or Knee Arthroplasty

NCT03071250
View directory record Official record
Conditions
Knee Osteoarthritis, Hip Osteoarthritis, Knee Arthritis, Hip Arthritis
Interventions
Total knee or Hip Arthroplasty
Procedure
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Oct 19, 2026, 10:19 AM EDT
Recruiting Not applicable Interventional

The REPOSE (Reach for Equity in Pediatric Sleep Evaluation) Navigation Intervention

NCT06828835
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Reach for Equity in Pediatric Obstructive Sleep Evaluation (REPOSE), Usual Care
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
2 Years to 12 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 19, 2026, 10:19 AM EDT
Terminated Phase 4 Interventional Results available

Protocolized Diuretic Strategy in Cardiorenal Failure

NCT01921829
View directory record Official record
Conditions
Cardiac Failure, Renal Failure, Kidney Failure
Interventions
Protocolized Diuretic Strategy
Drug
Lead sponsor
Kelly V. Liang, MD
Other
Eligibility
21 Years and older · Male only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 21, 2017 · Synced Oct 19, 2026, 10:19 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Testing the Feasibility of Patient Controlled Sedation for Ventilated ICU Patients

NCT01606852
View directory record Official record
Conditions
Acute Respiratory Failure, Anxiety
Interventions
Dexmedetomidine
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 13, 2018 · Synced Oct 19, 2026, 10:19 AM EDT
Completed Not applicable Interventional

Early Identification and Action in CKD

NCT02208674
View directory record Official record
Conditions
Chronic Kidney Disease, Hypertension
Interventions
Protocolized, pharmacist-delivered CKD Action Plan
Other
Lead sponsor
Geisinger Clinic
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Danville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 15, 2016 · Synced Oct 19, 2026, 10:19 AM EDT
Completed Not applicable Interventional

Monitoring Organ Donors to Increase Transplantation Results (MOnIToR)

NCT00987714
View directory record Official record
Conditions
Transplantation
Interventions
Protocolized care
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
16 Years and older
Enrollment
556 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
8
States / cities
Norcross, Georgia • Cleveland, Ohio • Columbus, Ohio + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 19, 2026, 10:19 AM EDT
Completed Phase 4 Interventional Results available

Intubation Conditions Achieved With Rapid Co-administration of Rocuronium and Propofol Versus Classical Induction

NCT05509192
View directory record Official record
Conditions
Anesthesia
Interventions
MTPI, Classic Induction
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Oct 19, 2026, 10:19 AM EDT