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ClinicalTrials.gov public records Last synced Sep 22, 2026, 2:43 AM EDT

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Showing 1–24 of 138 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Pulmonary Vein Isolation procedure Clear all
Completed Not applicable Interventional Results available

TactiSense IDE Trial of TactiCath SE for Paroxysmal Atrial Fibrillation

NCT03354663
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
TactiCath SE
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
14
States / cities
Little Rock, Arkansas • La Jolla, California • Redwood City, California + 10 more
Source: ClinicalTrials.gov public record
Updated Oct 10, 2023 · Synced Sep 22, 2026, 2:43 AM EDT
Terminated Not applicable Interventional

Posterior Wall And Left Atrial Appendage Empiric Electrical Isolation for Non-Paroxysmal Atrial Fibrillation

NCT04216667
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Catheter ablation
Procedure
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 99 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
10
States / cities
Birmingham, Alabama • Larkspur, California • Boulder, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated Aug 30, 2023 · Synced Sep 22, 2026, 2:43 AM EDT
Completed Phase 2 Interventional

Combined Treatment of Arterial Hypertension and Atrial Fibrillation

NCT01897545
View directory record Official record
Conditions
Arterial Hypertension, Atrial Fibrillation
Interventions
Circumferential PV isolation, PV isolation+renal denervation
Procedure
Lead sponsor
Meshalkin Research Institute of Pathology of Circulation
Network
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 8, 2013 · Synced Sep 22, 2026, 2:43 AM EDT
Not listed Phase 4 Interventional

Treatment Of Atrial Fibrillation In Preserved Cardiac Function Heart Failure

NCT04160000
View directory record Official record
Conditions
Atrial Fibrillation, Heart Failure, Diastolic Heart Failure
Interventions
Catheter ablation, Rate or Rhythm control antiarrhythmic drugs for atrial fibrillation, Insertion of CardioMems Hemodynamic monitor, Empiric heart failure drug therapy
Device · Drug
Lead sponsor
Electrophysiology Research Foundation
Other
Eligibility
18 Years to 75 Years
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
7
States / cities
Flagstaff, Arizona • Jonesboro, Arkansas • Littleton, Colorado + 4 more
Source: ClinicalTrials.gov public record
Updated May 22, 2024 · Synced Sep 22, 2026, 2:43 AM EDT
Active, not recruiting Not applicable Interventional

STrategies for Catheter Ablation of peRsistent Atrial Fibrlllation

NCT04428944
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Wide Circumferential Pulmonary Vein Antrum Isolation (PVAI), Pulmonary Vein Antrum Isolation Plus Driver Ablation (PVAI+drivers), Pulmonary Vein Antrum Isolation Plus Box Isolation of Posterior Wall (PVAI+box)
Procedure
Lead sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Other
Eligibility
18 Years and older
Enrollment
617 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 22, 2026, 2:43 AM EDT
Not listed Not applicable Interventional

Impact of Anxiety on Cardiac Substrate Modification in Women With Atrial Fibrillation Undergoing Catheter Ablation

NCT02547584
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Catheter ablation
Procedure
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 9, 2019 · Synced Sep 22, 2026, 2:43 AM EDT
Recruiting Not applicable Interventional

Esophageal Temperature During PVI Using Q-DOT Micro

NCT06392932
View directory record Official record
Conditions
Atrial Fibrillation Paroxysmal
Interventions
QDOT Micro ablation catheter, ST SF ablation catheter
Device
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Sep 22, 2026, 2:43 AM EDT
Completed Not applicable Interventional Results available

Evaluation of QDOT MICRO™ Catheter for Pulmonary Vein Isolation in Subjects With Paroxysmal Atrial Fibrillation

NCT03775512
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
RF Ablation with QDOT Micro
Device
Lead sponsor
Biosense Webster, Inc.
Industry
Eligibility
18 Years and older
Enrollment
283 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
22
States / cities
Birmingham, Alabama • Atlantis, Florida • Jacksonville, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated Mar 15, 2023 · Synced Sep 22, 2026, 2:43 AM EDT
Completed Not applicable Interventional Results available

DiamondTemp™ Ablation System for the Treatment of Paroxysmal Atrial Fibrillation

NCT03334630
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation, Atrial Fibrillation
Interventions
DiamondTemp Ablation catheter, TactiCath Quartz Ablation catheter
Device
Lead sponsor
Medtronic Cardiac Ablation Solutions
Industry
Eligibility
18 Years and older
Enrollment
482 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
14
States / cities
Birmingham, Alabama • Los Angeles, California • Redwood City, California + 8 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Sep 22, 2026, 2:43 AM EDT
Completed No phase listed Observational

Studying Heart Ablation After Left Atrial Closure in High-Bleeding-Risk Atrial Fibrillation Patients

NCT07580937
View directory record Official record
Conditions
Atrial Fibrillation, Atrial Arrhythmia
Interventions
Data collection
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
10
States / cities
Chicago, Illinois • Evanston, Illinois • Boston, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 22, 2026, 2:43 AM EDT
Completed Not applicable Interventional Results available

TactiCath Contact Force Ablation Catheter Study for Atrial Fibrillation

NCT01278953
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
Catheter ablation to treat paroxysmal atrial fibrillation
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 20, 2019 · Synced Sep 22, 2026, 2:43 AM EDT
Completed Not applicable Interventional Results available

Assessing Arrhythmias After Ablation Using Implantable Recorders

NCT01176617
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Reveal XT implantable loop recorder
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Sep 22, 2026, 2:43 AM EDT
Recruiting Not applicable Interventional

Renal Denervation + PVI vs PVI Alone for Persistent AF

NCT05116384
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
catheter ablation, renal artery denervation
Device
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Short Hills, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Sep 22, 2026, 2:43 AM EDT
Completed Phase 3 Interventional

Renal Artery Denervation In Addition to Catheter Ablation To Eliminate Atrial Fibrillation

NCT01873352
View directory record Official record
Conditions
Atrial Fibrillation, Hypertension
Interventions
catheter ablation, renal sympathetic denervation
Procedure
Lead sponsor
Meshalkin Research Institute of Pathology of Circulation
Network
Eligibility
18 Years to 75 Years
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Short Hills, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Sep 22, 2026, 2:43 AM EDT
Terminated Not applicable Interventional

Ablation Versus Medical Management of Atrial Fibrillation in HFpEF

NCT04282850
View directory record Official record
Conditions
Atrial Fibrillation, Heart Failure With Normal Ejection Fraction
Interventions
Pulmonary Vein Isolation
Procedure
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years to 90 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 22, 2026, 2:43 AM EDT
Completed Not applicable Interventional

Timing of Direct Current Cardioversion (DCC) in Patients Undergoing Ablation of Persistent/Permanent Atrial Fibrillation

NCT02429648
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
DCC first then PVI, PVI then DCC after
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 9, 2017 · Synced Sep 22, 2026, 2:43 AM EDT
Completed Phase 2 Interventional

Combined Treatment of Resistant Hypertension and Atrial Fibrillation

NCT01117025
View directory record Official record
Conditions
Hypertension, Resistant to Conventional Therapy, Atrial Fibrillation
Interventions
Circumferential PV isolation, Circumferential PVI+renal denervation
Procedure
Lead sponsor
Meshalkin Research Institute of Pathology of Circulation
Network
Eligibility
18 Years to 70 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 9, 2013 · Synced Sep 22, 2026, 2:43 AM EDT
Not listed Phase 3 Interventional

PV Reconnection After PVAI at Different Power Settings and Adenosine Provocation

NCT01672346
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
PVAI followed by adenosine provocation
Procedure
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years to 80 Years
Enrollment
188 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
2
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Sep 22, 2026, 2:43 AM EDT
Not listed Not applicable Interventional

Pulmonary Vein Antrum Isolation (PVAI) Plus Scar Homogenization and Non-PV Triggers Ensure Long-term Recurrence-free Survival in Non-paroxysmal Atrial Fibrillation

NCT01672138
View directory record Official record
Conditions
Persistent Atrial Fibrillation, Long-standing Persistent Atrial Fibrillation
Interventions
Pulmonary Vein Antrum Isolation, scar homogenization, Non-PV triggers ablation
Procedure
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years to 80 Years
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
2
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Nov 15, 2018 · Synced Sep 22, 2026, 2:43 AM EDT
Completed Not applicable Interventional Results available

STOP AF First: Cryoballoon Catheter Ablation in an Antiarrhythmic Drug Naive Paroxysmal Atrial Fibrillation

NCT03118518
View directory record Official record
Conditions
Atrial Fibrillation, Atrial Fibrillation New Onset
Interventions
Cryoablation, Antiarrhythmic drug
Device · Drug
Lead sponsor
Medtronic Cardiac Ablation Solutions
Industry
Eligibility
18 Years to 80 Years
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
24
States / cities
Birmingham, Alabama • Anchorage, Alaska • Newport Beach, California + 21 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Sep 22, 2026, 2:43 AM EDT
Not listed Not applicable Interventional

aMAZE Study: LAA Ligation Adjunctive to PVI for Persistent or Longstanding Persistent Atrial Fibrillation

NCT02513797
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
LARIAT + PVI, Pulmonary Vein Isolation
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
53
States / cities
Phoenix, Arizona • La Jolla, California • Los Angeles, California + 44 more
Source: ClinicalTrials.gov public record
Updated Sep 4, 2021 · Synced Sep 22, 2026, 2:43 AM EDT
Terminated Not applicable Interventional Results available

The Substrate and Intervention Mechanisms for Persistent Atrial Fibrillation Trial

NCT02918396
View directory record Official record
Conditions
Persistent Atrial Fibrillation
Interventions
Scar-Based Radio-frequency Ablation, Rotor Anchors Radio-frequency Ablation, Conventional PVI by Radio-frequency Ablation
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 3, 2018 · Synced Sep 22, 2026, 2:43 AM EDT
Not listed Phase 2 Interventional

Sole-Therapy Treatment of Atrial Fibrillation

NCT00566176
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Surgical Ablation using the AtriCure Bipolar System
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2017
U.S. locations
5
States / cities
Tampa, Florida • Cincinnati, Ohio • Oklahoma City, Oklahoma + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2013 · Synced Sep 22, 2026, 2:43 AM EDT
Terminated Not applicable Interventional

Strategies in Patients Undergoing Repeat AF Ablation

NCT05185310
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Ablation
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Sep 22, 2026, 2:43 AM EDT