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These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 15, 2026, 8:44 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 29 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Pulsed Low Intensity Ultrasound Clear all

Conditions: Chronic Pain, Sickle Cell Disease, Chronic Pelvic Pain Syndrome
Interventions: Focused PCM-Guided CMN LIFU, Unfocused Control LIFU; Device
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2032
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Glioblastoma, Recurrent Glioblastoma, GBM
Interventions: SonoCloud-9 (SC9), Carboplatin, Lomustine, Temozolomide; Device · Drug
Lead sponsor: CarThera; Industry
Eligibility: 18 Years and older
Enrollment: 560 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 23
States / cities: Phoenix, Arizona • Los Angeles, California • San Francisco, California + 16 more

Conditions: Cervical Radiculopathy
Interventions: Ultrasound-guided electrical dry needling, Conventional Physical Therapy; Procedure
Lead sponsor: Liberty University; Other
Eligibility: 18 Years and older
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Macon, Georgia

Conditions: Breast Cysts, Breast Tumors
Interventions: X-ray and ultrasound imaging scanning, Photoacoustic imaging scans for breast cancer screening; Procedure
Lead sponsor: University of Michigan; Other
Eligibility: 30 Years to 80 Years · Female only
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2020
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Disc Herniation
Interventions: Discogen Low pulsed ultrasound treatment, Discogen Sham Treatment; Device
Lead sponsor: Columbia University; Other
Eligibility: 21 Years to 75 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm, Autonomic Nervous System Diseases
Interventions: Right-Sided Cervical Sympathetic Block at C6, Transcutaneous Auricular Vagal Nerve Stimulation (taVNS); Procedure · Device
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2030
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Alcohol Use Disorder, Chronic Pain
Interventions: Episodic Future Thinking, Control Episodic Thinking, Low-intensity Focused Ultrasound, Sham Low-intensity Focused Ultrasound; Behavioral · Device
Lead sponsor: Kirstin M Gatchalian; Other
Eligibility: 21 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Major Depressive Disorder
Interventions: Low-intensity focused ultrasound; Other
Lead sponsor: Laureate Institute for Brain Research, Inc.; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Metatarsal Fracture
Interventions: AccelStim (LIPUS); Device
Lead sponsor: Orthofix Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 3
States / cities: Evanston, Illinois • Mount Prospect, Illinois • Laurel, Maryland

Conditions: Drug Resistant Epilepsy
Interventions: Focused ultrasound; Device
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Schizophrenia, Schizophrenia Schizoaffective
Interventions: PLIFUS, Sham PLIFUS, MRI; Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 50 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 2
States / cities: Brooklyn, New York • New York, New York

Conditions: Depression, Anhedonia
Interventions: Low Intensity Focused Ultrasound Pulsation (LIFUP); Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 65 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Brain Diseases, Memory Disorders, Learning Disabilities, Cognitive Impairment
Interventions: Low Intensity Focused Ultrasound Pulsation to Amygdala, Low Intensity Focused Ultrasound Pulsation to Entorhinal Cortex; Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 35 Years to 90 Years
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Stuttering, Developmental Stuttering
Interventions: High DC LIFU, Sham; Device
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Stroke, Arm Weakness as a Consequence of Stroke, Upper Extremity Hemiparesis, Upper Extremity Impairments, Upper Extremity Weakness
Interventions: Low intensity focused ultrasound stimulation; Device
Lead sponsor: Duke University; Other
Eligibility: 21 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Healthy Controls
Interventions: Low-intensity focused ultrasound; Other
Lead sponsor: Laureate Institute for Brain Research, Inc.; Other
Eligibility: 18 Years to 65 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Deep Brain Stimulation, Mild Alzheimer's Disease
Interventions: Low-Intensity Focused Ultrasound Pulsation (LIFUP); Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 50 Years to 90 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Depression
Interventions: Low Intensity Focused Ultrasound; Device
Lead sponsor: Ocean State Research Institute, Inc.; Other
Eligibility: 22 Years to 75 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Depression, Anxiety, Obsessive Compulsive Disorder (OCD)
Interventions: ATTN201 head-worn focused ultrasound; Device
Lead sponsor: Attune Neurosciences Inc; Industry
Eligibility: 22 Years to 80 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Treatment-Resistant Depression
Interventions: Low-intensity focused ultrasound; Other
Lead sponsor: Laureate Institute for Brain Research, Inc.; Other
Eligibility: 18 Years to 65 Years
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Mitigation of Fracture Non-union in Patients at Risk
Interventions: Low intensity pulsed ultrasound; Device
Lead sponsor: Bioventus LLC; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 12,387 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Jericho, New York

Conditions: Glioblastoma, Adult
Interventions: SonoCloud-9, Carboplatin; Device · Drug
Lead sponsor: CarThera; Industry
Eligibility: 18 Years and older
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 2
States / cities: Chicago, Illinois • Houston, Texas

Conditions: Fibromyalgia, Complex Regional Pain Syndromes, Chronic Pain
Interventions: Low-intensity Focused Ultrasound (LIFU), Sham Low-intensity focused ultrasound (LIFU); Device
Lead sponsor: Carilion Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Brain Imaging, Mild Cognitive Impairment, Alzheimer Disease, Deep Brain Stimulation
Interventions: Excitation, Inhibition; Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 55 Years and older
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Search by objective public record fields.

Focused Ultrasound Neuromodulation for Chronic Pain

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

Ultrasound-Guided Electrical Dry Needling for Chronic Cervical Radiculopathy

Simulated Screening Study for Breast Imaging

Discogen for Low Back Pain

Noninvasive CA Monitoring Validation and Autonomic Modulation in Aneurysmal Subarachnoid Hemorrhage

Decision Making in Chronic Pain and Alcohol Use Disorder

Low Intensity Ultrasound Neuromodulation of Repetitive Negative Thinking In Depression

A Data Collection Protocol to Evaluate the Real World Usage of the Orthofix AccelStim Device to Treat Fresh Metatarsal Fractures

Low Intensity Focused Ultrasound Epilepsy: A Pilot Trial

Focused Ultrasound Modulation of the Globus Pallidus Interna in Schizophrenia

Investigating LIFUP in Anhedonic Depression

Low Intensity Focused Ultrasound for Learning and Memory and Emotion Regulation

Noninvasive Thalamocortical Neuromodulation With Low-Intensity Focused Ultrasound for Persistent Developmental Stuttering

Low Intensity Focused Ultrasound Stimulation in Stroke Patients - Parameter Optimization

Dose-Dependent Effects of Low-Intensity Focused Ultrasound

Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease

Low Intensity Focused Ultrasound: a New Paradigm for Depression and Anxiety

Focused Ultrasound for Behavioral Health

Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression

Observational, Non-interventional Use of LIPUS to Mitigate Fracture Non-union in Patients at Risk

Safety and Efficacy of Transient Opening of the Blood-brain Barrier (BBB) With the SonoCloud-9

Low-Intensity Focused Ultrasound For Insular Neuromodulation in Chronic Pain

Deep Brain Stimulation with LIFUP for Mild Cognitive Impairment and Mild Alzheimer's Disease