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ClinicalTrials.gov public records Last synced Nov 6, 2026, 1:01 PM EST

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Showing 1–24 of 26 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Radiofrequency denervation Clear all

Conditions: Low Back Pain
Interventions: Radiofrequency denervation of medial branches, 0.5% bupivacaine, 2% lidocaine, Radiofrequency denervation; Procedure · Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 151 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Baltimore, Maryland

Conditions: Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction, Hypertension, Vascular Diseases, Cardiovascular Diseases, Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction
Interventions: Pulmonary Artery Denervation (PADN), Sham procedure control; Device
Lead sponsor: Pulnovo Medical, Inc.; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 750 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 14
States / cities: Tucson, Arizona • New Haven, Connecticut • Weston, Florida + 9 more

Conditions: Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions: Radiofrequency Ablation (RFA), Perineural Steroid Injection; Procedure
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 100 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Advanced Cancers, Pain
Interventions: Cordotomy, Pain/Symptom Questionnaire, Sharpness Sensory Testing, Heat Pain Sensory Testing; Procedure · Behavioral
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Ventricular Tachycardia
Interventions: Renal sympathetic denervation, VT ablation alone; Device
Lead sponsor: Vivek Reddy; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Low Back Pain
Interventions: RFA at 90 degrees Celsius, RFA at 80 degrees Celsius, C-arm guided 20-gauge radiofrequency needle; Procedure · Device
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older
Enrollment: 199 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2022
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Sacroiliac Joint Pain
Interventions: SInergy Cooled Radiofrequency, Medical Management; Device · Other
Lead sponsor: Avanos Medical; Other
Eligibility: 21 Years to 110 Years
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 15
States / cities: Washington D.C., District of Columbia • Bloomington, Illinois • New Orleans, Louisiana + 11 more

Conditions: Arterial Hypertension, Atrial Fibrillation
Interventions: Circumferential PV isolation, PV isolation+renal denervation; Procedure
Lead sponsor: Meshalkin Research Institute of Pathology of Circulation; Network
Eligibility: 18 Years to 70 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Hypertension, Resistant to Conventional Therapy, Atrial Fibrillation
Interventions: Circumferential PV isolation, Circumferential PVI+renal denervation; Procedure
Lead sponsor: Meshalkin Research Institute of Pathology of Circulation; Network
Eligibility: 18 Years to 70 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: New York, New York

Conditions: Uncontrolled Hypertension, Atrial Fibrillation
Interventions: Boston Scientific Vessix Renal Denervation System; Device
Lead sponsor: Vivek Reddy; Other
Eligibility: 18 Years to 85 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2019
U.S. locations: 6
States / cities: Sacramento, California • Kansas City, Kansas • Boston, Massachusetts + 2 more

Conditions: Chronic Knee Pain, Osteoarthritis, Knee
Interventions: Nerve Block with Radiofrequency Ablation, Nerve Block with Sham Radiofrequency Ablation; Procedure
Lead sponsor: Randall Brewer, MD, CPI; Other
Eligibility: 50 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Shreveport, Louisiana

Conditions: Low Back Pain
Interventions: radiofrequency denervation; Procedure
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Baltimore, Maryland

Conditions: Low Back Pain, Lumbar Radiculopathy
Interventions: Facet intervention, Sacroiliac joint injection, Epidural steroid injection; Procedure
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 346 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2021
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Diabetes Mellitus, Type 2
Interventions: iRF System Hepatic Denervation; Device
Lead sponsor: Metavention; Industry
Eligibility: 22 Years to 70 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 8
States / cities: Birmingham, Alabama • Stanford, California • Orlando, Florida + 5 more

Conditions: Chronic Sacroiliac Joint Pain
Interventions: Treatment with SInergy™ System, Conservative Treatment; Device · Other
Lead sponsor: Baylis Medical Company; Industry
Eligibility: 18 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2010
U.S. locations: 1
States / cities: Chestnut Hill, Massachusetts

Conditions: Arthritis;Lumbosacral, Osteo Arthritis Knee, Sacroiliitis, Hip Osteoarthritis, Arthritis, Degenerative
Interventions: Cooled radiofrequency ablation; Device
Lead sponsor: International Spine, Pain and Performance Center; Other
Eligibility: 21 Years and older
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Arlington, Virginia

Conditions: Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Interventions: Renal Denervation, Catheter Ablation; Device
Lead sponsor: Vivek Reddy; Other
Eligibility: 18 Years and older
Enrollment: 143 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 8
States / cities: Jonesboro, Arkansas • San Francisco, California • Thousand Oaks, California + 5 more

Conditions: Atrial Fibrillation, Hypertension
Interventions: catheter ablation, renal sympathetic denervation; Procedure
Lead sponsor: Meshalkin Research Institute of Pathology of Circulation; Network
Eligibility: 18 Years to 75 Years
Enrollment: 302 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2019
U.S. locations: 1
States / cities: Short Hills, New Jersey

Conditions: Osteoarthritis, Knee, Pain, Nerve; Lesion
Interventions: genicular nerve diagnostic block with lidocaine (local anesthetic), genicular nerve radiofrequency ablation; Procedure
Lead sponsor: Northwestern University; Other
Eligibility: 30 Years to 80 Years
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Atrial Fibrillation
Interventions: renal denervation, Catheter ablation; Device
Lead sponsor: Vivek Reddy; Other
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 13
States / cities: Phoenix, Arizona • Jonesboro, Arkansas • Loma Linda, California + 9 more

Conditions: Other Acute Pain, Chronic Pain
Interventions: Sinergy, Placebo sham; Device
Lead sponsor: Baylis Medical Company; Industry
Eligibility: 18 Years and older
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Bradenton, Florida

Conditions: Resistant Hypertension
Interventions: Splanchnic Nerve Denervation, Renal Denervation Only; Device
Lead sponsor: Tulane University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: Lumbar Facet Joint Pain, Low Back Pain
Interventions: Intra-articular injection, Medial branch block, Saline injection; Procedure
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 225 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 2
States / cities: Baltimore, Maryland • Bethesda, Maryland

Conditions: Atrial Fibrillation
Interventions: catheter ablation, renal artery denervation; Device
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Short Hills, New Jersey

Search by objective public record fields.

Efficacy and Cost: Benefit Ratio of 0, 1, and 2 Medial Branch Blocks for Lumbar Facet Joint Radiofrequency Denervation

A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

Radiofrequency Ablation and Steroid Versus Steroid Alone for Relief of Pain in Patients With Advanced Knee and Hip Osteoarthritis

Cordotomy for Refractory Cancer Pain

REnal Sympathetic dEnervaTion as an a Adjunct to Catheter-based VT Ablation

Effect of the Temperature Used in Thermal Radiofrequency Ablation

Lateral Branch Cooled Radiofrequency Denervation vs. Conservative Therapy for Sacroiliac Joint Pain

Combined Treatment of Arterial Hypertension and Atrial Fibrillation

Combined Treatment of Resistant Hypertension and Atrial Fibrillation

Adjunctive Renal Denervation in the Treatment of Atrial Fibrillation

Radiofrequency For Chronic Knee Pain Post-Arthroplasty

A Placebo-Controlled Study Assessing Lateral Branch Radiofrequency Denervation for Sacroiliac (SI) Joint Pain

Predictive Factors for LBP Interventional Treatment Outcomes

Evaluation of the Integrated Radio Frequency Denervation System to Improve Glycemic Control in Type 2 Diabetic Subjects

Trial Comparing Treatment With SInergy™ System to Conservative Treatment for Chronic Sacroiliac Joint Pain

Cooled RF Lesion MRI Characteristics

ULTRA-HFIB-Redo: Ultrasound-based Renal Sympathetic Denervation vs Control in Redo Ablation Patients

Renal Artery Denervation In Addition to Catheter Ablation To Eliminate Atrial Fibrillation

Diagnostic Genicular Nerve Block Prior to Radiofrequency Ablation for Knee Osteoarthritis Pain

Ultrasound-Based Renal Sympathetic Denervation as Adjunctive Upstream Therapy During Atrial Fibrillation Ablation

Trial Assessing Cooled Radiofrequency Denervation as a Treatment for Sacroiliac Joint Pain Using the Sinergy System

The RESPLASH Study

Medial Branch Blocks vs. Intra-articular Injections: Randomized, Controlled Study

Renal Denervation + PVI vs PVI Alone for Persistent AF