Independent directory Public ClinicalTrials.gov records United States
Clinical Trials Finder
Objective public record navigation
Search Results

Search by objective public record fields.

Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results come from ClinicalTrials.gov. When the live registry is unavailable, a clearly labeled stored copy may be shown.

Clear filters

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 1, 2026, 12:19 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 123 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Reduced Nicotine Cigarettes Clear all
Completed Not applicable Interventional Results available

Smoking Cessation Pilot for People Living With HIV (PLWH)

NCT04808609
View directory record Official record
Conditions
Smoking Cessation, Smoking, Smoking Behaviors, Smoking Reduction, Smoking, Tobacco, Smoking, Cigarette, Hiv, HIV/AIDS
Interventions
Lumme mobile phone application, Standard of Care
Device · Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2023 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Not applicable Interventional

Electronic Cigarettes as a Harm Reduction Strategy Among Patients With COPD

NCT04465318
View directory record Official record
Conditions
COPD
Interventions
E-cigarette (EC), Nicotine Replacement Therapy (NRT), Smoking Harm Reduction Counseling Sessions
Other · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 75 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 15, 2023 · Synced Oct 1, 2026, 12:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

E-Cigarettes: Dynamic Patterns of Use and Health Effects

NCT02527980
View directory record Official record
Conditions
Smoking, Nicotine Dependence
Interventions
No intervention: observation only
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
422 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
2
States / cities
Madison, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 10, 2019 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Health Effects of SLT, Cigarette Smoking, and New Tobacco Products

NCT00469079
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine gum and lozenge, Taboka, Camel Snus
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 70 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 1, 2019 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Not applicable Interventional

The Impact of Innovative Tax Proposals on Purchase Patterns

NCT05370313
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Market Price Condition (control), Tobacco Parity Tax Condition, Nicotine-Content Tax Condition, Harm-Reduction Tax Condition, Modified Risk Tobacco Product (MRTP) Tax Condition
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
285 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Buffalo, New York • Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2

NCT05473585
View directory record Official record
Conditions
Smoking, Smoking, Cigarette, E-Cig Use, Nicotine Dependence
Interventions
very low nicotine content cigarettes, normal nicotine content cigarettes, Study e-cigarette
Other
Lead sponsor
Duke University
Other
Eligibility
21 Years and older
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 19, 2023 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does Abstinence From E-cigarettes Produce Withdrawal Symptoms?

NCT02825459
View directory record Official record
Conditions
Substance Withdrawal Syndrome
Interventions
Abstinence from e-cigarettes
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
2
States / cities
Baltimore, Maryland • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Nov 20, 2018 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace

NCT03272685
View directory record Official record
Conditions
Tobacco Smoking, Nicotine Dependence
Interventions
Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years and older
Enrollment
799 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
6
States / cities
San Francisco, California • Minneapolis, Minnesota • Durham, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Phase 4 Interventional Results available

Identifying Treatments to Motivate Smokers to Quit

NCT01122238
View directory record Official record
Conditions
Smoking, Smoking Cessation, Motivation, Nicotine Dependence
Interventions
Nicotine Patch, Nicotine Gum, Motivational Interviewing, Smoking Reduction, No Intervention, Nicotine Patch + Nicotine Gum
Drug · Behavioral · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
517 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 16, 2015 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Trial for Harm Reduction With Incentives & Vaping E-cigarettes

NCT06111053
View directory record Official record
Conditions
Obesity, Smoking Cessation
Interventions
ENDS, CI, No ENDS, NI
Other
Lead sponsor
Brown University
Other
Eligibility
21 Years to 99 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 18, 2024 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Behavioral Intervention for Low Income Depressed Smokers in Drug Treatment

NCT01372254
View directory record Official record
Conditions
Cigarette Smoking, Drug Use
Interventions
Standard Treatment, BAD-AS, Transdermal Nicotine Patch
Behavioral · Drug
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years to 65 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 18, 2022 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Gradual vs. Abrupt Cessation Treatment for Smoking

NCT00297492
View directory record Official record
Conditions
Smoking Cessation
Interventions
Reduction Phone Counseling, Abrupt Phone Counseling, Minimal Abrupt Phone Counseling, Pre-Quit Nicotine Lozenges, Post-Quit Nicotine Lozenges
Behavioral · Drug
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Sep 20, 2013 · Synced Oct 1, 2026, 12:19 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches

NCT06678789
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Dependence, Smoking Cessation
Interventions
High Nicotine Dose, Low Nicotine Dose
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine

NCT01944423
View directory record Official record
Conditions
Nicotine Addiction, Panic Attack
Interventions
d-cycloserine, Pill Placebo, Nicotine replacement therapy, Panic and Smoking Reduction Treatment
Drug · Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated May 19, 2021 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Abuse Liability of Reduced Nicotine Content Cigarettes Within a Complex Tobacco Marketplace

NCT02951143
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
SPECTRUM cigarettes, SPECTRUM cigarettes between
Drug
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
305 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 22, 2021 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Phase 4 Interventional Results available

Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers

NCT02378714
View directory record Official record
Conditions
Nicotine Dependence, Major Depressive Disorder
Interventions
Varenicline, BASC, Standard treatment
Drug · Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
2
States / cities
Chicago, Illinois • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 29, 2021 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use

NCT02870218
View directory record Official record
Conditions
Nicotine Addiction, Cigarette Smoking
Interventions
Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds
Drug
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 14, 2022 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tobacco/Nicotine Purchase Patterns Across SES

NCT06795997
View directory record Official record
Conditions
Smoking Behaviors, Smoking, Non-Tobacco Products, Smoking, Cigarette
Interventions
Tax Conditions, Control Condition
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years and older
Enrollment
663 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reduced Nicotine Content Cigarettes in Smokers of Lower Socioeconomic Status

NCT01928719
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Reduced Nicotine Content Cigarettes, Same Nicotine Content Cigarettes
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
280 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 1, 2019 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use and Harm Exposure in New Low Nicotine Cigarettes

NCT01202942
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Quest
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 65 Years
Enrollment
246 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 19, 2013 · Synced Oct 1, 2026, 12:19 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Modeling Tobacco Regulatory Impacts in Appalachia Using the Experimental Tobacco Marketplace

NCT06234722
View directory record Official record
Conditions
Tobacco Use, Cigarette Use
Interventions
Very Low Nicotine Cigarette, Reduced nicotine regulatory environment, Restriction on characterizing flavors in combustible nicotine products, Restriction on characterizing flavors in noncombustible nicotine products
Drug · Behavioral
Lead sponsor
Mikhail N Koffarnus
Other
Eligibility
21 Years and older
Enrollment
473 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Oct 1, 2026, 12:19 AM EDT
Recruiting Phase 2 Interventional

E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder

NCT05722561
View directory record Official record
Conditions
Opioid Use Disorder, Cigarette Smoking
Interventions
Telehealth Motivational Counseling, Nicotine Replacement Product, National Institute on Drug Abuse (NIDA) Standardized Research Electronic Cigarette (SREC).
Behavioral · Drug · Device
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 75 Years
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

E-cigarette Nicotine Study

NCT04709471
View directory record Official record
Conditions
Nicotine Dependence, Electronic Cigarette Use, Cigarette Smoking
Interventions
Nicotine, Juul e-cigarette, Reduction
Drug · Device · Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
21 Years and older
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Aug 26, 2022 · Synced Oct 1, 2026, 12:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

RITCH: Reducing Disparities in Tobacco Cessation Outcomes

NCT02785536
View directory record Official record
Conditions
Smoking Cessation
Interventions
RITCh Treatment, Standard Treatment
Behavioral
Lead sponsor
The City College of New York
Other
Eligibility
18 Years and older
Enrollment
256 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 1, 2016 · Synced Oct 1, 2026, 12:19 AM EDT