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Showing 1–24 of 647 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Reward Clear all
Completed Not applicable Interventional Results available

Prevention of Anhedonia in Children

NCT05988138
View directory record Official record
Conditions
Anhedonia, Depression
Interventions
Family Promoting Positive Emotions, Psychoeducation
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
8 Years to 12 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 4, 2026, 6:18 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Parent Encouragement And Coaching of Happiness in Youth

NCT06725160
View directory record Official record
Conditions
Depression, Parent-Child Relations
Interventions
Parent Coaching, Active Control
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
4 Years to 99 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Sep 4, 2026, 6:18 PM EDT
Completed Phase 2 Interventional Results available

Reduced Carbohydrate Versus Fat in Obese Subjects

NCT00846040
View directory record Official record
Conditions
Obesity
Interventions
Reduced fat diet, Reduced carbohydrate diet, Drug: f-18 fallypride, fMRI, PET
Other · Drug · Device
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 45 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 14, 2021 · Synced Sep 4, 2026, 6:18 PM EDT
Completed Not applicable Interventional

Telemedicine for Women With Anhedonia in Bipolar and Unipolar Disorder

NCT02494050
View directory record Official record
Conditions
Depression, Bipolar Disorder, Anhedonia
Interventions
Behavioral Activation-Full, Behavioral Activation-Short, Bipolar Disorder Collaborative Care
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
21 Years to 65 Years · Female only
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Sep 4, 2026, 6:18 PM EDT
Not yet recruiting Phase 1 Interventional

Psilocybin as a Novel Therapy for Residual Anhedonia

NCT07607938
View directory record Official record
Conditions
Anhedonia, Emotional Blunting
Interventions
Psilocybin, Placebo
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 4, 2026, 6:18 PM EDT
Completed Not applicable Interventional

Comparing Engage to PST for Late Life Depression

NCT02086201
View directory record Official record
Conditions
Major Depression
Interventions
Problem Solving Therapy, Engage
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
60 Years and older
Enrollment
262 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
2
States / cities
White Plains, New York • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 28, 2021 · Synced Sep 4, 2026, 6:18 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Examining the Impact of Transcranial Focused Ultrasound (tFUS) on Reward Neural Circuitry

NCT05875181
View directory record Official record
Conditions
Impulsive Behavior
Interventions
tFUS, Sham tFUS
Device
Lead sponsor
Mary Phillips, MD MD (Cantab)
Other
Eligibility
18 Years to 35 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Sep 4, 2026, 6:18 PM EDT
Terminated Early Phase 1 Interventional Results available

Behavioral Effects of Drugs Inpatient 44 Neurobehavioral Mechanisms of Opioid Choice

NCT06312657
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Drug Cue, Money, Withdrawal, Remifentanil
Behavioral · Drug
Lead sponsor
Joshua A. Lile, Ph.D.
Other
Eligibility
18 Years to 50 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 4, 2026, 6:18 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

A Personalized Behavioral Intervention to Improve Physical Activity, Sleep and Cognition in Sedentary Older Adults

NCT03959202
View directory record Official record
Conditions
Sleep
Interventions
ELDERFITNESS, Control
Behavioral · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
60 Years to 85 Years
Enrollment
129 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 7, 2023 · Synced Sep 4, 2026, 6:18 PM EDT
Completed Not applicable Interventional Results available

Neurocognitive Factors in Substance Use Treatment Response: The Ways of Rewarding Abstinence Project

NCT03799341
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
Prize-Based Contingency Management, Treatment As Usual Outpatient Substance Use Treatment
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Sep 4, 2026, 6:18 PM EDT
Completed Not applicable Interventional

Comparing the Effectiveness of Two Produce Prescription Approaches On Fruit and Vegetable Intake and Food Security, While Exploring Implementation Outcomes Such as Reach, Implementation, Sustainability, and Cost

NCT06263751
View directory record Official record
Conditions
Food Insecurity
Interventions
Product prescription program- NutriConnect Credit, Product prescription program- NutriConnect Delivery
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 99 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 4, 2026, 6:18 PM EDT
Withdrawn Not applicable Interventional

A Novel Intervention for Training Auditory Attention in Adolescents With Autism Spectrum Disorder

NCT03625999
View directory record Official record
Conditions
Autism Spectrum Disorder, Autism
Interventions
video game training exercise
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
13 Years to 20 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 8, 2021 · Synced Sep 4, 2026, 6:18 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Opioid Modulation and Neural Reward Activation in Healthy Adults

NCT04854551
View directory record Official record
Conditions
Alcohol Drinking, Opioid Use, Unspecified
Interventions
Naltrexone, Placebo
Drug · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 35 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 27, 2023 · Synced Sep 4, 2026, 6:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Minds and Mentors Program (MiMP)- R61

NCT04233671
View directory record Official record
Conditions
Opioid-use Disorder, Medication Assisted Treatment, Substance Use Disorders
Interventions
Mindfulness based relapse prevention and peer mentoring
Behavioral
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
19 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
Birmingham, Alabama • Homewood, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 20, 2023 · Synced Sep 4, 2026, 6:18 PM EDT
Not listed No phase listed Observational

The Promus Element Rewards Study

NCT01794065
View directory record Official record
Conditions
Coronary Stenosis
Interventions
Not listed
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 10, 2014 · Synced Sep 4, 2026, 6:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Incentivizing Physical Activity Using Gamification, A Pilot Study

NCT02850614
View directory record Official record
Conditions
Obesity, Physical Activity
Interventions
gaming application to encourage physical activity, FitBit
Behavioral · Device
Lead sponsor
University of Vermont
Other
Eligibility
15 Years to 18 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Sep 4, 2026, 6:18 PM EDT
Terminated Phase 4 Interventional Results available

Lisdexamfetamine's Effect In ADHD in the Brain and Cognition

NCT02170298
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder
Interventions
Lisdexamfetamine
Drug
Lead sponsor
University of California, Davis
Other
Eligibility
12 Years to 30 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Dec 25, 2019 · Synced Sep 4, 2026, 6:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Randomized Clinical Trial of Intensive Computer-based Cognitive Remediation in Recent-onset Schizophrenia

NCT01773239
View directory record Official record
Conditions
Schizophrenia
Interventions
TARA computer-based exercises
Behavioral
Lead sponsor
Posit Science Corporation
Industry
Eligibility
18 Years to 35 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Sep 4, 2026, 6:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Physical Therapy Integrated With Mindfulness for Patients With Chronic Pain and Opioid Treatment

NCT05875207
View directory record Official record
Conditions
Chronic Pain, Pain, Musculoskeletal, Opioid Use, Physical Therapy
Interventions
Mindfulness based practice, Control/Standard Physical Therapy
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 75 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
2
States / cities
Gainesville, Florida • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Sep 4, 2026, 6:18 PM EDT
Recruiting Phase 4 Interventional

Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression

NCT06610305
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Transdermal estradiol, Progesterone, Transdermal placebo patch, placebo capsule
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Sep 4, 2026, 6:18 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Motivating Survey Compliance: Game Play Study 1

NCT03738254
View directory record Official record
Conditions
Patient Reported Outcome Measures, Compliance
Interventions
The Guardians: A smartphone game, Paper Survey, Electronic Survey
Other
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
6 Years to 24 Years
Enrollment
232 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 21, 2019 · Synced Sep 4, 2026, 6:18 PM EDT
Completed Not applicable Interventional

Affective Modulation of Positivity for Alcohol Use Disorder

NCT04278365
View directory record Official record
Conditions
Anxiety, Depression, Alcohol Use Disorder
Interventions
Positive affect training
Behavioral
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 31, 2020 · Synced Sep 4, 2026, 6:18 PM EDT
Terminated Phase 2 Interventional Results available

Effects of ABT-089 on Smoking Abstinence Symptoms and Reward

NCT01756053
View directory record Official record
Conditions
Nicotine Addiction
Interventions
ABT-089, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 28, 2014 · Synced Sep 4, 2026, 6:18 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

An Investigation of Early Life Stress and Depression

NCT01701258
View directory record Official record
Conditions
Major Depressive Disorder (MDD), History of Childhood Sexual Abuse (CSA)
Interventions
Amisulpride, Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
20 Years to 45 Years · Female only
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
2
States / cities
Belmont, Massachusetts • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2025 · Synced Sep 4, 2026, 6:18 PM EDT