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Showing 1–24 of 33 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Salsalate Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia

NCT03482440
View directory record Official record
Conditions
Preeclampsia
Interventions
Salsalate Oral Tablet, Placebo Oral Tablet
Drug
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
2
States / cities
Iowa City, Iowa • University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 2, 2025 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Free Fatty Acids-Induced Hypertension in Obese Subjects (Aim #2)

NCT02406586
View directory record Official record
Conditions
Hypertension, Diabetes
Interventions
Salsalate, Carvedilol, Placebo, Intralipid 20%
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 7, 2019 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Inflammation and Vascular Function in Atherosclerosis

NCT00760019
View directory record Official record
Conditions
Atherosclerosis
Interventions
salsalate, placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 15, 2017 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Phase 4 Interventional Results available

The Effects of Anti-Inflammatory Treatment on Insulin Resistance in Healthy Volunteers

NCT00339833
View directory record Official record
Conditions
Type 2 Diabetes, Diabetes
Interventions
Salsalate, Placebo
Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 45 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 5, 2013 · Synced Sep 3, 2026, 2:18 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers Results available

Vascular Function, Endothelin, and Inflammation in Pre-diabetic Obesity Versus Lean Healthy Controls

NCT00837590
View directory record Official record
Conditions
Pre-diabetes, Obesity
Interventions
Chronic salsalate, Acute Salsalate
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 55 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Phase 1 Interventional

Salsalate in Patients Mild to Moderate Alzheimer's Disease

NCT03277573
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Salsalate, Placebo
Drug
Lead sponsor
Adam Boxer
Other
Eligibility
50 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
2
States / cities
San Diego, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2025 · Synced Sep 3, 2026, 2:18 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use

NCT06489249
View directory record Official record
Conditions
Electronic Cigarette Use, Endothelial Dysfunction, Inflammation
Interventions
Placebo, Salsalate 750 MG Oral Tablet [DISALCID]
Drug
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 24 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Not applicable Interventional Results available

Salsalate for Insulin Resistance in Schizophrenia

NCT01182727
View directory record Official record
Conditions
Schizophrenia, Insulin Resistance
Interventions
salsalate
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy of Salsalate to Treat Endothelial Dysfunction in HIV-infected Adults

NCT01046682
View directory record Official record
Conditions
HIV, Endothelial Dysfunction, Inflammation, Insulin Resistance
Interventions
Salsalate
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 6, 2015 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

The Study of Inflammation on Blood Glucose Levels in Obese People

NCT00258115
View directory record Official record
Conditions
Obesity
Interventions
salsalate
Drug
Lead sponsor
Joslin Diabetes Center
Other
Eligibility
18 Years to 30 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2003
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 14, 2018 · Synced Sep 3, 2026, 2:18 AM EDT
Active, not recruiting Phase 1Phase 2 Interventional

Omega-3 Fatty Acid Lipidomics in Diabetes Peripheral Neuropathy

NCT05169060
View directory record Official record
Conditions
Diabetic Neuropathies
Interventions
Fish Oil Concentrate, 1000 Mg Oral Capsule, Salsalate Oral Tablet
Drug
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
Iowa City, Iowa • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Treating Inflammation in Polycystic Ovary Syndrome to Ameliorate Ovarian Dysfunction

NCT03229408
View directory record Official record
Conditions
Polycystic Ovary Syndrome
Interventions
Salsalate, Placebo
Drug · Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 9, 2025 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Using Salsalate to Target Adipocyte Macrophage Infiltration

NCT02130804
View directory record Official record
Conditions
Diabetes Risk
Interventions
Salsalate (4 g/day), Placebo (4 g/day)
Drug
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 35 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 4, 2014 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Phase 1 Interventional

A 6 Month, Open-Label, Pilot Futility Clinical Trial of Oral Salsalate for Progressive Supranuclear Palsy

NCT02422485
View directory record Official record
Conditions
Progressive Supranuclear Palsy
Interventions
Salsalate
Drug
Lead sponsor
Adam Boxer
Other
Eligibility
50 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
2
States / cities
San Francisco, California • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 31, 2021 · Synced Sep 3, 2026, 2:18 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Endometriosis and Microvascular Dysfunction: Role of Inflammation

NCT05069740
View directory record Official record
Conditions
Endometriosis
Interventions
Salsalate Pill, Placebo
Drug
Lead sponsor
Penn State University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Salsalate on Bed Rest-Induced Vascular Dysfunction

NCT00553995
View directory record Official record
Conditions
Insulin Resistance
Interventions
salsalate, Placebo
Drug
Lead sponsor
Boston University
Other
Eligibility
18 Years to 64 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 9, 2017 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Targeting Inflammation to Treat Cardiovascular Aging

NCT01775865
View directory record Official record
Conditions
Vascular Stiffness, Endothelial Dysfunction, Diastolic Dysfunction
Interventions
Salsalate, Placebo (for salsalate)
Drug
Lead sponsor
Gary L. Pierce
Other
Eligibility
18 Years to 79 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 30, 2018 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Targeting Inflammation Using Salsalate for Type 2 Diabetes-Stage II

NCT00799643
View directory record Official record
Conditions
Type 2 Diabetes Mellitus
Interventions
Salsalate, Salsalate Placebo
Drug
Lead sponsor
Joslin Diabetes Center
Other
Eligibility
18 Years to 75 Years
Enrollment
638 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2008
U.S. locations
21
States / cities
Birmingham, Alabama • San Diego, California • New Haven, Connecticut + 18 more
Source: ClinicalTrials.gov public record
Updated Dec 10, 2017 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Salsalate Therapy to Reduce Insulin Resistance and Cardiovascular Risk

NCT00330733
View directory record Official record
Conditions
Atherosclerosis, Cardiovascular Disease, Inflammation, Insulin Resistance, Noninsulin-dependent Diabetes Mellitus
Interventions
Salsalate, Placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 75 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 20, 2020 · Synced Sep 3, 2026, 2:18 AM EDT
Terminated Phase 2 Interventional Results available

Trial To Evaluate the Efficacy of Oral Salsalate in the Treatment of Older Adults With Unexplained Anemia

NCT01506726
View directory record Official record
Conditions
Anemia
Interventions
Salsalate, Placebo
Drug
Lead sponsor
Harvey Jay Cohen
Other
Eligibility
65 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
12
States / cities
Summerfield, Florida • Savannah, Georgia • Chicago, Illinois + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 17, 2016 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Phase 2 Interventional Results available

Pilot Study to Determine Effects of Salsalate in Type 1 Diabetes and Painful Peripheral Neuropathy

NCT01480297
View directory record Official record
Conditions
Peripheral Neuropathy, Type 1 Diabetes
Interventions
Salsalate
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 70 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 23, 2015 · Synced Sep 3, 2026, 2:18 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Evaluation of Oral Lipid Ingestion in Relation to Ovarian Androgen Secretion in Polycystic Ovary Syndrome (PCOS)

NCT01489319
View directory record Official record
Conditions
Polycystic Ovary Syndrome
Interventions
Salsalate
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 9, 2017 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Targeting INflammation Using SALsalate in Type 2 Diabetes (TINSAL-T2D)

NCT00392678
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Salsalate, Placebo
Drug
Lead sponsor
Joslin Diabetes Center
Other
Eligibility
18 Years to 75 Years
Enrollment
277 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
16
States / cities
New Haven, Connecticut • Washington D.C., District of Columbia • Winter Park, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2019 · Synced Sep 3, 2026, 2:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Beneficial Effect of Salicylates: Insulin Action, Secretion or Clearance?

NCT02007577
View directory record Official record
Conditions
Pre Diabetes, Insulin Resistant
Interventions
salsalate, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
30 Years to 60 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 4, 2016 · Synced Sep 3, 2026, 2:18 AM EDT