Targeting INflammation Using SALsalate in Type 2 Diabetes (TINSAL-T2D)
Public ClinicalTrials.gov record NCT00392678. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Targeting Inflammation in Type 2 Diabetes: Clinical Trial Using Salsalate
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Growing evidence over recent years supports a potential role for low grade chronic inflammation in the pathogenesis of insulin resistance and type 2 diabetes. In this study we will determine whether salsalate, a member of the commonly used Non-Steroidal Anti-Inflammatory Drug (NSAID) class, is effective in lowering sugars in patients with type 2 diabetes. The study will determine whether salicylates represent a new pharmacological option for diabetes management. The study is conducted in two stages. The first stage is a dose ranging study, administering salsalate compared to placebo over three months. The primary objective of Stage 2 of the study is to evaluate the effects of salsalate on blood sugar control in diabetes; the tolerability of salsalate use in patients with type 2 diabetes (T2D); and the effects of salsalate on measures of inflammation, the metabolic syndrome, and cardiac risk. The second stage is a second trial and posted under alternate registration.
Study identification
- NCT ID
- NCT00392678
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 277 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 30, 2006
- Primary completion
- Jun 30, 2008
- Completion
- Nov 30, 2010
- Last update posted
- Apr 7, 2019
2006 – 2010
United States locations
- U.S. sites
- 16
- U.S. states
- 12
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Chapel Medical Group | New Haven | Connecticut | 06511 | — |
| MedStar Research Institute | Washington D.C. | District of Columbia | 20003-4393 | — |
| Endocrine Clinical Research | Winter Park | Florida | 32746 | — |
| Kaiser Permanente | Atlanta | Georgia | 30084 | — |
| Emory School of Medicine | Atlanta | Georgia | 30303 | — |
| University of Illinois at Chicago | Chicago | Illinois | 60612 | — |
| Tulane University | New Orleans | Louisiana | 70112 | — |
| Joslin Diabetes Center | Boston | Massachusetts | 02215 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68105 | — |
| Kaleida Health Center | Buffalo | New York | 14226 | — |
| North Shore Diabetes and Endocrine Associates | New Hyde Park | New York | 11042 | — |
| Columbia University | New York | New York | 10032 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27599 | — |
| University of Texas Southwestern | Dallas | Texas | 75390 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00392678, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 7, 2019 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00392678 live on ClinicalTrials.gov.