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ClinicalTrials.gov public records Last synced Nov 14, 2026, 5:57 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 433–456 of 517 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Sepsis Clear all

Conditions: Sepsis
Interventions: Nelfinavir; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Sepsis
Interventions: Inhaled nitric oxide, Sham inhaled nitric oxide; Drug · Other
Lead sponsor: National Institute of General Medical Sciences (NIGMS); NIH
Eligibility: 14 Years and older
Enrollment: 49 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Camden, New Jersey

Conditions: Sepsis, Acute Kidney Injury
Interventions: AZD4144, Placebo; Drug
Lead sponsor: AstraZeneca; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 124 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 16
States / cities: Phoenix, Arizona • Newport Beach, California • Kansas City, Kansas + 11 more

Conditions: Allogeneic Stem Cell Transplantation
Interventions: Xylitol, Placebo; Other
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 4 Months to 25 Years
Enrollment: 256 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 3
States / cities: Aurora, Colorado • Boston, Massachusetts • Cincinnati, Ohio

Conditions: Herpes Simplex Virus, Neonatal Sepsis
Interventions: Acyclovir; Drug
Lead sponsor: Phillip Brian Smith; Other
Eligibility: Up to 45 Days
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 3
States / cities: Wichita, Kansas • New Orleans, Louisiana • Durham, North Carolina

Conditions: Septic Shock, Inflammation, Glucose Homeostasis, Organ Dysfunction, Health-related Quality of Life
Interventions: Exenatide, Exenatide vehicle; Drug
Lead sponsor: Seattle Children's Hospital; Other
Eligibility: 1 Month to 18 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Sepsis, Trauma
Interventions: Not listed
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 5
States / cities: Bamberg, South Carolina • Barnwell, South Carolina • Charleston, South Carolina + 2 more

Conditions: Sepsis, Severe Sepsis, End Organ Damage, Multi Organ Failure
Interventions: vitamin D3, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 80 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Burn Wounds
Interventions: SynePure Wound Cleanser and Catasyn Advanced Technology Hydrogel, SILVADENE Cream 1% (silver sulfadiazine); Device · Drug
Lead sponsor: Synedgen, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 2 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: Sepsis, Septic Shock, Sepsis, Severe, Volume Overload
Interventions: VExUS score; Diagnostic Test
Lead sponsor: The Miriam Hospital; Other
Eligibility: 18 Years and older
Enrollment: 152 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Infection
Interventions: Not listed
Lead sponsor: Abbott Diagnostics Division; Industry
Eligibility: 18 Years and older
Enrollment: 872 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 2
States / cities: Atlanta, Georgia

Conditions: Severe Sepsis
Interventions: S.A.F.E.BT; Device
Lead sponsor: B. Braun Medical Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 2
States / cities: Lexington, Kentucky • Baltimore, Maryland

Conditions: Sepsis, Adult Disease, Emergency Department, Severe Sepsis
Interventions: Diagnostic Test: CBC-DIFF Monocyte Volume Width Distribution (MDW); Device
Lead sponsor: Beckman Coulter, Inc.; Industry
Eligibility: 19 Years to 89 Years
Enrollment: 198 participants
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Hackensack, New Jersey

Conditions: Pneumonia, Blood Stream Infection, Urinary Tract Infections, Respiratory Tract Infection (Including Tracheobronchitis), Sepsis
Interventions: Not listed
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years and older
Enrollment: 155 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 3
States / cities: Chicago, Illinois • New York, New York

Conditions: Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia
Interventions: Best Practice, Biospecimen Collection, Cytarabine, Electronic Health Record Review, Placebo Administration, Xylitol-containing Oral Wipe; Other · Procedure · Drug
Lead sponsor: Children's Oncology Group; Network
Eligibility: 1 Year to 25 Years
Enrollment: 556 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2033
U.S. locations: 39
States / cities: Birmingham, Alabama • Little Rock, Arkansas • Madera, California + 35 more

Conditions: Sepsis, Severe Sepsis, Systemic Inflammatory Response Syndrome, Sepsis Syndrome
Interventions: Not listed
Lead sponsor: Inverness Medical Innovations; Industry
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007
U.S. locations: 3
States / cities: Boston, Massachusetts • Cleveland, Ohio • Philadelphia, Pennsylvania

Conditions: Septic Shock
Interventions: Hydrocortisone, sodium succinate, Normal saline; Drug
Lead sponsor: Jerry Zimmerman; Other
Eligibility: 1 Month to 17 Years
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 18
States / cities: Tucson, Arizona • Los Angeles, California • Oakland, California + 15 more

Conditions: New Onset Atrial Fibrillation, Sepsis, Respiratory Failure
Interventions: Amiodarone in Parenteral Dosage Form, Amiodarone Pill, Direct Current Cardioversion (DCC), Rate-control therapy; Drug · Procedure
Lead sponsor: Our Lady of the Lake Hospital; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Baton Rouge, Louisiana

Conditions: Septic Shock
Interventions: Near-infrared spectroscopy assessment; Diagnostic Test
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 186 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Critical Illness, Sepsis, Acute Respiratory Failure (ARF), Multi-organ Failure, Acute Kidney Injury, Delirium Confusional State, Shock
Interventions: Point-of-care large language model decision support (ChatGPT-5); Other
Lead sponsor: MetroWest Artificial Intelligence Research Workgroup; Other
Eligibility: 18 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Framingham, Massachusetts

Conditions: Candidiasis
Interventions: Eraxis (anidulafungin), Diflucan (fluconazole), Vfend (voriconazole); Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years and older
Enrollment: 282 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 39
States / cities: Birmingham, Alabama • Little Rock, Arkansas • Los Angeles, California + 25 more

Conditions: Septic Shock, Endotoxemia
Interventions: Toraymyxin PMX 20R Extracorporeal Hemoperfusion Cartridge; Device
Lead sponsor: Spectral Diagnostics (US) Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 157 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 20
States / cities: Birmingham, Alabama • Little Rock, Arkansas • San Francisco, California + 16 more

Conditions: Autoimmune Diseases, Lupus Erythematosus, Systemic, Communicable Diseases
Interventions: Not listed
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 2,500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2028
U.S. locations: 3
States / cities: Atlanta, Georgia

Conditions: Bacterial Infection, Benign Neoplasm, Malignant Neoplasm, Methicillin-Resistant Staphylococcus Aureus Infection, Myeloid Neoplasm, Recurrent Childhood Acute Lymphoblastic Leukemia, Recurrent Childhood Acute Myeloid Leukemia
Interventions: Chlorhexidine Gluconate Skin Cleanser, Laboratory Biomarker Analysis, Mild Soap Skin Cleanser, Questionnaire Administration; Procedure · Other
Lead sponsor: Children's Oncology Group; Network
Eligibility: 2 Months to 21 Years
Enrollment: 177 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2020
U.S. locations: 53
States / cities: Duarte, California • Long Beach, California • Los Angeles, California + 44 more

Search by objective public record fields.

The Effects of HIV Protease Inhibitors in Severe Sepsis

Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis

A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

Xylitol BSI Multisite - Reduction of Bloodstream Infections From Oral Organisms in Pediatric Stem Cell Transplant

A Study to Describe the Pharmacokinetics of Acyclovir in Premature Infants (PTN_Acyclo)

Pharmacology of Exenatide in Pediatric Sepsis

Critical Care Excellence in Sepsis and Trauma

Vitamin D Status in Patients With Severe Sepsis

SWC for Treatment of Superficial Partial-Thickness Burns

De-resuscitation Informed by Ultrasound for Patients With Sepsis

Procurement of Human Specimens for the Evaluation of Early Markers of Sepsis

S.A.F.E.BT System Extracorporeal Treatment With DIAPACT CRRT

Sepsis Post Market Clinical Utility Simple Endpoint Study - HUMC

Optimizing Clinical Use of Polymyxin B

Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia

The Utility of Ischemia Modified Albumin (IMA) in Sepsis

Stress Hydrocortisone In Pediatric Septic Shock

Rapid Atrial Fibrillation Treatment Strategy

Near Infrared Spectroscopy (St02)

Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial

Study Will Evaluate The Safety And Efficacy Of Anidulafungin In Patients With Candidemia Or Invasive Candidiasis

Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study

Comparative Autoantibody and Immunologic Cell Marker Study

Chlorhexidine Gluconate Cleansing in Preventing Central Line Associated Bloodstream Infection and Acquisition of Multi-drug Resistant Organisms in Younger Patients With Cancer or Undergoing Donor Stem Cell Transplant